메뉴 건너뛰기




Volumn 37, Issue 19, 2009, Pages 6587-6599

Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR 3; LENTIVIRUS VECTOR; MESSENGER RNA; RETINOIC ACID INDUCIBLE PROTEIN I; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

EID: 71049120498     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp714     Document Type: Article
Times cited : (36)

References (59)
  • 1
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond,S.M., Bernstein,E., Beach,D. and Hannon,G.J. (2000) An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature, 404, 293-296.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 2
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez,J., Patkaniowska,A., Urlaub,H., Luhrmann,R. and Tuschl,T. (2002) Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell, 110, 563-574.
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Luhrmann, R.4    Tuschl, T.5
  • 3
    • 27744537851 scopus 로고    scopus 로고
    • Human RISC couples microRNA biogenesis and posttranscriptional gene silencing
    • Gregory,R.I., Chendrimada,T.P., Cooch,N. and Shiekhattar,R. (2005) Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell, 123, 631-640.
    • (2005) Cell , vol.123 , pp. 631-640
    • Gregory, R.I.1    Chendrimada, T.P.2    Cooch, N.3    Shiekhattar, R.4
  • 4
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira,S., Uematsu,S. and Takeuchi,O. (2006) Pathogen recognition and innate immunity. Cell, 124, 783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 6
    • 2442705429 scopus 로고    scopus 로고
    • Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
    • Kariko,K., Bhuyan,P., Capodici,J. and Weissman,D. (2004) Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol., 172, 6545-6549.
    • (2004) J. Immunol , vol.172 , pp. 6545-6549
    • Kariko, K.1    Bhuyan, P.2    Capodici, J.3    Weissman, D.4
  • 7
    • 1542306855 scopus 로고    scopus 로고
    • Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
    • Kim,D.H., Longo,M., Han,Y., Lundberg,P., Cantin,E. and Rossi,J.J. (2004) Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol., 22, 321-325.
    • (2004) Nat. Biotechnol , vol.22 , pp. 321-325
    • Kim, D.H.1    Longo, M.2    Han, Y.3    Lundberg, P.4    Cantin, E.5    Rossi, J.J.6
  • 9
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge,A.D., Sood,V., Shaw,J.R., Fang,D., McClintock,K. and MacLachlan,I. (2005) Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol., 23, 457-462.
    • (2005) Nat. Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 10
    • 0038419800 scopus 로고    scopus 로고
    • Induction of an interferon response by RNAi vectors in mammalian cells
    • Bridge,A.J., Pebernard,S., Ducraux,A., Nicoulaz,A.L. and Iggo,R. (2003) Induction of an interferon response by RNAi vectors in mammalian cells. Nat. Genet., 34, 263-264.
    • (2003) Nat. Genet , vol.34 , pp. 263-264
    • Bridge, A.J.1    Pebernard, S.2    Ducraux, A.3    Nicoulaz, A.L.4    Iggo, R.5
  • 14
    • 33744791510 scopus 로고    scopus 로고
    • Essential role of mda-5 in type I IFN responses to polyriboinosinic: Polyribocytidylic acid and encephalomyocarditis picornavirus
    • Gitlin,L., Barchet,W., Gilfillan,S., Cella,M., Beutler,B., Flavell,R.A., Diamond,M.S. and Colonna,M. (2006) Essential role of mda-5 in type I IFN responses to polyriboinosinic: Polyribocytidylic acid and encephalomyocarditis picornavirus. Proc. Natl Acad. Sci. USA, 103, 8459-8464.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 8459-8464
    • Gitlin, L.1    Barchet, W.2    Gilfillan, S.3    Cella, M.4    Beutler, B.5    Flavell, R.A.6    Diamond, M.S.7    Colonna, M.8
  • 16
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan,E., Curran,J., Hofmann,K., Moradpour,D., Binder,M., Bartenschlager,R. and Tschopp,J. (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature, 437, 1167-1172.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 17
    • 24144461689 scopus 로고    scopus 로고
    • Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
    • Seth,R.B., Sun,L., Ea,C.K. and Chen,Z.J. (2005) Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell, 122, 669-682.
    • (2005) Cell , vol.122 , pp. 669-682
    • Seth, R.B.1    Sun, L.2    Ea, C.K.3    Chen, Z.J.4
  • 18
    • 24944538819 scopus 로고    scopus 로고
    • VISA is an adapter protein required for virus-triggered IFN-beta signaling
    • Xu,L.G., Wang,Y.Y., Han,K.J., Li,L.Y., Zhai,Z. and Shu,H.B. (2005) VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell, 19, 727-740.
    • (2005) Mol. Cell , vol.19 , pp. 727-740
    • Xu, L.G.1    Wang, Y.Y.2    Han, K.J.3    Li, L.Y.4    Zhai, Z.5    Shu, H.B.6
  • 19
    • 10344259136 scopus 로고    scopus 로고
    • The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter
    • Andrejeva,J., Childs,K.S., Young,D.F., Carlos,T.S., Stock,N., Goodbourn,S. and Randall,R.E. (2004) The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc. Natl Acad. Sci. USA, 101, 17264-17269.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 17264-17269
    • Andrejeva, J.1    Childs, K.S.2    Young, D.F.3    Carlos, T.S.4    Stock, N.5    Goodbourn, S.6    Randall, R.E.7
  • 27
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri,T., Yu,J.W., Datta,P., Wu,J. and Alnemri,E.S. (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature, 458, 509-513.
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 31
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
    • Chiu,Y.H., Macmillan,J.B. and Chen,Z.J. (2009) RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell, 138, 576-591.
    • (2009) Cell , vol.138 , pp. 576-591
    • Chiu, Y.H.1    Macmillan, J.B.2    Chen, Z.J.3
  • 32
    • 34249817897 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro
    • Robida,J.M., Nelson,H.B., Liu,Z. and Tang,H. (2007) Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro. J. Virol., 81, 5829-5840.
    • (2007) J. Virol , vol.81 , pp. 5829-5840
    • Robida, J.M.1    Nelson, H.B.2    Liu, Z.3    Tang, H.4
  • 33
    • 35648957775 scopus 로고    scopus 로고
    • Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system
    • Zhu,H., Dong,H., Eksioglu,E., Hemming,A., Cao,M., Crawford,J.M., Nelson,D.R. and Liu,C. (2007) Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system. Gastroenterology, 133, 1649-1659.
    • (2007) Gastroenterology , vol.133 , pp. 1649-1659
    • Zhu, H.1    Dong, H.2    Eksioglu, E.3    Hemming, A.4    Cao, M.5    Crawford, J.M.6    Nelson, D.R.7    Liu, C.8
  • 34
    • 25844465627 scopus 로고    scopus 로고
    • Defective Jak-Stat activation in hepatoma cells is associated with hepatitis C viral IFN-alpha resistance
    • Zhu,H., Nelson,D.R., Crawford,J.M. and Liu,C. (2005) Defective Jak-Stat activation in hepatoma cells is associated with hepatitis C viral IFN-alpha resistance. J. Interferon Cytokine Res., 25, 528-539.
    • (2005) J. Interferon Cytokine Res , vol.25 , pp. 528-539
    • Zhu, H.1    Nelson, D.R.2    Crawford, J.M.3    Liu, C.4
  • 35
    • 0035047145 scopus 로고    scopus 로고
    • Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: Common and unique pathways
    • Iwamura,T., Yoneyama,M., Yamaguchi,K., Suhara,W., Mori,W., Shiota,K., Okabe,Y., Namiki,H. and Fujita,T. (2001) Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells, 6, 375-388.
    • (2001) Genes Cells , vol.6 , pp. 375-388
    • Iwamura, T.1    Yoneyama, M.2    Yamaguchi, K.3    Suhara, W.4    Mori, W.5    Shiota, K.6    Okabe, Y.7    Namiki, H.8    Fujita, T.9
  • 36
    • 0037117458 scopus 로고    scopus 로고
    • A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation
    • Zhu,F.X., King,S.M., Smith,E.J., Levy,D.E. and Yuan,Y. (2002) A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Proc. Natl Acad. Sci. USA, 99, 5573-5578.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 5573-5578
    • Zhu, F.X.1    King, S.M.2    Smith, E.J.3    Levy, D.E.4    Yuan, Y.5
  • 37
    • 8644278061 scopus 로고    scopus 로고
    • Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach
    • Waninger,S., Kuhen,K., Hu,X., Chatterton,J.E., Wong-Staal,F. and Tang,H. (2004) Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach. J. Virol. 78, 12829-12837.
    • (2004) J. Virol , vol.78 , pp. 12829-12837
    • Waninger, S.1    Kuhen, K.2    Hu, X.3    Chatterton, J.E.4    Wong-Staal, F.5    Tang, H.6
  • 38
    • 4544277478 scopus 로고    scopus 로고
    • Determinants of interferon-stimulated gene induction by RNAi vectors
    • Pebernard,S. and Iggo,R.D. (2004) Determinants of interferon-stimulated gene induction by RNAi vectors. Differentiation, 72, 103-111.
    • (2004) Differentiation , vol.72 , pp. 103-111
    • Pebernard, S.1    Iggo, R.D.2
  • 40
    • 20444442721 scopus 로고    scopus 로고
    • Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes
    • Li,K., Chen,Z., Kato,N., Gale,M. Jr. and Lemon,S.M. (2005) Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. J. Biol. Chem., 280 16739-16747.
    • (2005) J. Biol. Chem , vol.280 , pp. 16739-16747
    • Li, K.1    Chen, Z.2    Kato, N.3    Gale Jr., M.4    Lemon, S.M.5
  • 41
    • 43949123575 scopus 로고    scopus 로고
    • Cyclophilin a is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro
    • Yang,F., Robotham,J.M., Nelson,H.B., Irsigler,A., Kenworthy,R. and Tang,H. (2008) Cyclophilin a is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. J. Virol., 82, 5269-5278.
    • (2008) J. Virol , vol.82 , pp. 5269-5278
    • Yang, F.1    Robotham, J.M.2    Nelson, H.B.3    Irsigler, A.4    Kenworthy, R.5    Tang, H.6
  • 42
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou,L., Holt,A.C., Medzhitov,R. and Flavell,R.A. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature, 413, 732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 43
    • 31144472895 scopus 로고    scopus 로고
    • Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression
    • Nelson,H.B. and Tang,H. (2006) Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression. J. Virol., 80, 1181-1190.
    • (2006) J. Virol , vol.80 , pp. 1181-1190
    • Nelson, H.B.1    Tang, H.2
  • 45
    • 34848837959 scopus 로고    scopus 로고
    • Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression
    • Su,Z.Z., Sarkar,D., Emdad,L., Barral,P.M. and Fisher,P.B. (2007) Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression. J. Cell Physiol., 213 502-510.
    • (2007) J. Cell Physiol , vol.213 , pp. 502-510
    • Su, Z.Z.1    Sarkar, D.2    Emdad, L.3    Barral, P.M.4    Fisher, P.B.5
  • 46
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp,T.R., Bernards,R. and Agami,R. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 48
    • 33646588689 scopus 로고    scopus 로고
    • Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro
    • Robbins,M.A., Li,M., Leung,I., Li,H., Boyer,D.V., Song,Y., Behlke,M.A. and Rossi,J.J. (2006) Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro. Nat. Biotechnol., 24, 566-571.
    • (2006) Nat. Biotechnol , vol.24 , pp. 566-571
    • Robbins, M.A.1    Li, M.2    Leung, I.3    Li, H.4    Boyer, D.V.5    Song, Y.6    Behlke, M.A.7    Rossi, J.J.8
  • 49
    • 0024853731 scopus 로고
    • Gamma-monomethyl phosphate: A cap structure in spliceosomal U6 small nuclear RNA
    • Singh,R. and Reddy,R. (1989) Gamma-monomethyl phosphate: A cap structure in spliceosomal U6 small nuclear RNA. Proc. Natl Acad. Sci. USA, 86, 8280-8283.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 8280-8283
    • Singh, R.1    Reddy, R.2
  • 50
    • 0025165208 scopus 로고
    • Capping of mammalian U6 small nuclear RNA in vitro is directed by a conserved stem-loop and AUAUAC sequence: Conversion of a noncapped RNA into a capped RNA
    • Singh,R., Gupta,S. and Reddy,R. (1990) Capping of mammalian U6 small nuclear RNA in vitro is directed by a conserved stem-loop and AUAUAC sequence: Conversion of a noncapped RNA into a capped RNA. Mol. Cell Biol., 10, 939-946.
    • (1990) Mol. Cell Biol , vol.10 , pp. 939-946
    • Singh, R.1    Gupta, S.2    Reddy, R.3
  • 51
    • 24944560377 scopus 로고    scopus 로고
    • A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
    • Stegmeier,F., Hu,G., Rickles,R.J., Hannon,G.J. and Elledge,S.J. (2005) A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl Acad. Sci. USA, 102, 13212-13217.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13212-13217
    • Stegmeier, F.1    Hu, G.2    Rickles, R.J.3    Hannon, G.J.4    Elledge, S.J.5
  • 52
    • 39749119301 scopus 로고    scopus 로고
    • Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication
    • Targett-Adams,P., Boulant,S. and McLauchlan,J. (2008) Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication. J. Virol., 82, 2182-2195.
    • (2008) J. Virol , vol.82 , pp. 2182-2195
    • Targett-Adams, P.1    Boulant, S.2    McLauchlan, J.3
  • 53
    • 33646453915 scopus 로고    scopus 로고
    • Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    • Weber,F., Wagner,V., Rasmussen,S.B., Hartmann,R. and Paludan,S.R. (2006) Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J. Virol., 80, 5059-5064.
    • (2006) J. Virol , vol.80 , pp. 5059-5064
    • Weber, F.1    Wagner, V.2    Rasmussen, S.B.3    Hartmann, R.4    Paludan, S.R.5
  • 54
    • 33646851580 scopus 로고    scopus 로고
    • Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B
    • Miller,S., Sparacio,S. and Bartenschlager,R. (2006) Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B. J. Biol. Chem., 281, 8854-8863.
    • (2006) J. Biol. Chem , vol.281 , pp. 8854-8863
    • Miller, S.1    Sparacio, S.2    Bartenschlager, R.3
  • 56
    • 54949149143 scopus 로고    scopus 로고
    • Seeking membranes: Positive-strand RNA virus replication complexes
    • Denison,M.R. (2008) Seeking membranes: Positive-strand RNA virus replication complexes. PLoS Biol., 6, e270.
    • (2008) PLoS Biol , vol.6
    • Denison, M.R.1
  • 57
    • 33748069824 scopus 로고    scopus 로고
    • siRNA and isRNA: Two edges of one sword
    • Schlee,M., Hornung,V. and Hartmann,G. (2006) siRNA and isRNA: Two edges of one sword. Mol. Ther., 14, 463-470.
    • (2006) Mol. Ther , vol.14 , pp. 463-470
    • Schlee, M.1    Hornung, V.2    Hartmann, G.3
  • 59
    • 0036229427 scopus 로고    scopus 로고
    • Design of HIV vectors for efficient gene delivery into human hematopoietic cells
    • Yam,P.Y., Li,S., Wu,J., Hu,J., Zaia,J.A. and Yee,J.K. (2002) Design of HIV vectors for efficient gene delivery into human hematopoietic cells. Mol. Ther., 5, 479-484.
    • (2002) Mol. Ther , vol.5 , pp. 479-484
    • Yam, P.Y.1    Li, S.2    Wu, J.3    Hu, J.4    Zaia, J.A.5    Yee, J.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.