Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-κB-, and p53-dependent pathway

American Journal of Respiratory Cell and Molecular Biology

Volumn 41, Issue 6, 2009, Pages 742-755

  Suzuki, Tomoko ^a,b   Yamashita, Cory ^b,d   Zemans, Rachel L ^b,c   Briones, Natalie ^b   Van Linden, Annemie ^b   Downey, Gregory P ^a,b,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b DEPARTMENT OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Inflammation; Lung injury; Mitochondria; Neutrophils; Proteinase

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOCYTE ELASTASE; PROTEIN BAX; PROTEIN P53; PROTEINASE ACTIVATED RECEPTOR 1; PUMA PROTEIN;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; LEUKOCYTE ELASTASE; LUNG; MITOCHONDRIA; MODELS, BIOLOGICAL; NF-KAPPA B; PERMEABILITY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RECEPTOR, PAR-1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70949084458     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2008-0157OC     Document Type: Article

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