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Volumn 289, Issue 16, 2003, Pages 2104-2112

Injurious Mechanical Ventilation and End-Organ Epithelial Cell Apoptosis and Organ Dysfunction in an Experimental Model of Acute Respiratory Distress Syndrome

Author keywords

[No Author keywords available]

Indexed keywords

FAS LIGAND; HYBRID PROTEIN; IMMUNOGLOBULIN; BIOLOGICAL MARKER; CHEMOKINE; CREATININE; FAS ANTIGEN; FASLG PROTEIN, HUMAN; MEMBRANE PROTEIN;

EID: 0038324005     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.289.16.2104     Document Type: Article
Times cited : (595)

References (51)
  • 1
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-1349.
    • (2000) N Engl J Med , vol.342 , pp. 1334-1349
    • Ware, L.B.1    Matthay, M.A.2
  • 2
    • 0033533185 scopus 로고    scopus 로고
    • Acute respiratory distress syndrome
    • Wyncoll DL, Evans TW. Acute respiratory distress syndrome. Lancet. 1999;354:497-501.
    • (1999) Lancet , vol.354 , pp. 497-501
    • Wyncoll, D.L.1    Evans, T.W.2
  • 3
    • 0037116657 scopus 로고    scopus 로고
    • Characteristics and outcomes in adult patients receiving mechanical ventilation: A 28-day international study
    • Esteban A, Anzueto A, Frutos F, et al. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA. 2002;287:345-355.
    • (2002) JAMA , vol.287 , pp. 345-355
    • Esteban, A.1    Anzueto, A.2    Frutos, F.3
  • 4
    • 0035840891 scopus 로고    scopus 로고
    • Serial evaluation of the SOFA score to predict outcome in critically ill patients
    • Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001;286:1754-1758.
    • (2001) JAMA , vol.286 , pp. 1754-1758
    • Ferreira, F.L.1    Bota, D.P.2    Bross, A.3    Melot, C.4    Vincent, J.L.5
  • 5
    • 0029782755 scopus 로고    scopus 로고
    • The Logistic Organ Dysfunction system: A new way to assess organ dysfunction in the intensive care unit: ICU Scoring Group
    • Le Gall JR, Klar J, Lemeshow S, et al. The Logistic Organ Dysfunction system: a new way to assess organ dysfunction in the intensive care unit: ICU Scoring Group. JAMA. 1996;276:802-810.
    • (1996) JAMA , vol.276 , pp. 802-810
    • Le Gall, J.R.1    Klar, J.2    Lemeshow, S.3
  • 6
    • 0028784689 scopus 로고
    • Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome
    • Marshall JC, Cook DJ, Christou NV, et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23:1638-1652.
    • (1995) Crit Care Med , vol.23 , pp. 1638-1652
    • Marshall, J.C.1    Cook, D.J.2    Christou, N.V.3
  • 7
    • 0031942649 scopus 로고    scopus 로고
    • Ventilator-induced lung injury: Lessons from experimental studies
    • Dreyfuss D, Saumon G. Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med. 1998;157:294-323.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 294-323
    • Dreyfuss, D.1    Saumon, G.2
  • 8
    • 0031834452 scopus 로고    scopus 로고
    • Multiple system organ failure: Is mechanical ventilation a contributing factor?
    • Slutsky AS, Tremblay LN. Multiple system organ failure: is mechanical ventilation a contributing factor? Am J Respir Crit Care Med. 1998;157:1721-1725.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1721-1725
    • Slutsky, A.S.1    Tremblay, L.N.2
  • 9
    • 0031737722 scopus 로고    scopus 로고
    • Ventilator-induced injury: From barotrauma to biotrauma
    • Tremblay LN, Slutsky AS. Ventilator-induced injury: from barotrauma to biotrauma. Proc Assoc Am Physicians. 1998;110:482-488.
    • (1998) Proc Assoc Am Physicians , vol.110 , pp. 482-488
    • Tremblay, L.N.1    Slutsky, A.S.2
  • 10
    • 0345436055 scopus 로고    scopus 로고
    • Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomized controlled trial
    • Ranieri VM, Suter PM, Tortorella C, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA. 1999;282;54-61.
    • (1999) JAMA , vol.282 , pp. 54-61
    • Ranieri, V.M.1    Suter, P.M.2    Tortorella, C.3
  • 11
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
    • The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301-1308.
    • (2000) N Engl J Med , vol.342 , pp. 1301-1308
  • 12
    • 0034608918 scopus 로고    scopus 로고
    • Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome
    • Ranieri VM, Giunta F, Suter PM, Slutsky AS. Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome. JAMA. 2000;284:43-44.
    • (2000) JAMA , vol.284 , pp. 43-44
    • Ranieri, V.M.1    Giunta, F.2    Suter, P.M.3    Slutsky, A.S.4
  • 13
    • 0032484956 scopus 로고    scopus 로고
    • Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome
    • Amato MB, Barbas CS, Medeiros DM, et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med. 1998;338:347-354.
    • (1998) N Engl J Med , vol.338 , pp. 347-354
    • Amato, M.B.1    Barbas, C.S.2    Medeiros, D.M.3
  • 14
    • 0033251398 scopus 로고    scopus 로고
    • International consensus conferences in intensive care medicine: Ventilator-associated lung injury in ARDS
    • American Thoracic Society, European Society of Intensive Care Medicine, Societe de Reanimation Langue Francaise. International consensus conferences in intensive care medicine: ventilator-associated lung injury in ARDS. Intensive Care Med. 1999;25:1444-1452.
    • (1999) Intensive Care Med , vol.25 , pp. 1444-1452
  • 15
    • 0033532991 scopus 로고    scopus 로고
    • Progress in understanding ventilator-induced lung injury
    • Hudson LD. Progress in understanding ventilator-induced lung injury. JAMA. 1999;282:77-78.
    • (1999) JAMA , vol.282 , pp. 77-78
    • Hudson, L.D.1
  • 16
    • 0032573853 scopus 로고    scopus 로고
    • To die or not to die: An overview of apoptosis and its role in disease
    • Hetts SW. To die or not to die: an overview of apoptosis and its role in disease. JAMA. 1998;279: 300-307.
    • (1998) JAMA , vol.279 , pp. 300-307
    • Hetts, S.W.1
  • 17
    • 0033567086 scopus 로고    scopus 로고
    • Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS)
    • Matute-Bello G, Liles WC, Steinberg KP, et al. Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS). J Immunol. 1999;163:2217-2225.
    • (1999) J Immunol , vol.163 , pp. 2217-2225
    • Matute-Bello, G.1    Liles, W.C.2    Steinberg, K.P.3
  • 18
    • 0034101765 scopus 로고    scopus 로고
    • Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework
    • Papathanassoglou ED, Moynihan JA, Ackerman MH. Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? a review and a theoretical framework. Crit Care Med. 2000;28:537-549.
    • (2000) Crit Care Med , vol.28 , pp. 537-549
    • Papathanassoglou, E.D.1    Moynihan, J.A.2    Ackerman, M.H.3
  • 19
    • 0032919614 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis
    • Tesch GH, Schwarting A, Kinoshita K, et al. Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J Clin Invest. 1999;103: 73-80.
    • (1999) J Clin Invest , vol.103 , pp. 73-80
    • Tesch, G.H.1    Schwarting, A.2    Kinoshita, K.3
  • 20
    • 0031110570 scopus 로고    scopus 로고
    • Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway
    • Hiramatsu M, Hotchkiss RS, Karl IE, Buchman TG. Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock, 1997;7:247-253.
    • (1997) Shock , vol.7 , pp. 247-253
    • Hiramatsu, M.1    Hotchkiss, R.S.2    Karl, I.E.3    Buchman, T.G.4
  • 21
    • 0037012470 scopus 로고    scopus 로고
    • Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis
    • Coopersmith CM, Stromberg PE, Dunne WM, et al. Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA. 2002;287:1716-1721.
    • (2002) JAMA , vol.287 , pp. 1716-1721
    • Coopersmith, C.M.1    Stromberg, P.E.2    Dunne, W.M.3
  • 22
    • 0030739250 scopus 로고    scopus 로고
    • Apoptosis in lymphoid and parenchymal cells during sepsis: Findings in normal and T- and B-cell-deficient mice
    • Hotchkiss RS, Swanson PE, Cobb JP, et al. Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med. 1997;25:1298-1307.
    • (1997) Crit Care Med , vol.25 , pp. 1298-1307
    • Hotchkiss, R.S.1    Swanson, P.E.2    Cobb, J.P.3
  • 23
    • 0032770246 scopus 로고    scopus 로고
    • Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    • Hotchkiss RS, Swanson PE, Freeman BD, et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med. 1999;27: 1230-1251.
    • (1999) Crit Care Med , vol.27 , pp. 1230-1251
    • Hotchkiss, R.S.1    Swanson, P.E.2    Freeman, B.D.3
  • 24
    • 0033805712 scopus 로고    scopus 로고
    • Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock
    • Hotchkiss RS, Schmieg RE Jr, Swanson PE, et al. Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock. Crit Care Med. 2000;28:3207-3217.
    • (2000) Crit Care Med , vol.28 , pp. 3207-3217
    • Hotchkiss, R.S.1    Schmieg Jr., R.E.2    Swanson, P.E.3
  • 25
    • 0034807671 scopus 로고    scopus 로고
    • Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilation
    • Imai Y, Nakagawa S, Ito Y, et al. Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilation. J Appl Physiol. 2001; 91:1836-1844.
    • (2001) J Appl Physiol , vol.91 , pp. 1836-1844
    • Imai, Y.1    Nakagawa, S.2    Ito, Y.3
  • 26
    • 0030981335 scopus 로고    scopus 로고
    • Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model
    • Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest. 1997;99:944-952.
    • (1997) J Clin Invest , vol.99 , pp. 944-952
    • Tremblay, L.1    Valenza, F.2    Ribeiro, S.P.3    Li, J.4    Slutsky, A.S.5
  • 27
    • 0036894541 scopus 로고    scopus 로고
    • Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
    • Belperio JA, Keane MP, Burdick MD, et al. Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest. 2002;110:1703-1716.
    • (2002) J Clin Invest , vol.110 , pp. 1703-1716
    • Belperio, J.A.1    Keane, M.P.2    Burdick, M.D.3
  • 28
    • 0036895850 scopus 로고    scopus 로고
    • Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model
    • De Perrot M, Imai Y, Volgyesi GA, et al. Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model. J Thorac Cardiovasc Surg. 2002;124:1137-1144.
    • (2002) J Thorac Cardiovasc Surg , vol.124 , pp. 1137-1144
    • De Perrot, M.1    Imai, Y.2    Volgyesi, G.A.3
  • 30
    • 0030590654 scopus 로고    scopus 로고
    • Sensitive and specific immunoassays to detect rabbit IL-8 and MCP-1: Cytokines that mediate leukocyte recruitment to the lungs
    • Kajikawa O, Goodman RB, Johnson MC, Konishi K, Martin TR. Sensitive and specific immunoassays to detect rabbit IL-8 and MCP-1: cytokines that mediate leukocyte recruitment to the lungs. J Immunol Methods. 1996;197:19-29.
    • (1996) J Immunol Methods , vol.197 , pp. 19-29
    • Kajikawa, O.1    Goodman, R.B.2    Johnson, M.C.3    Konishi, K.4    Martin, T.R.5
  • 31
    • 0030795579 scopus 로고    scopus 로고
    • A sensitive immunoassay to detect the alpha-chemokine GRO in rabbit blood and lung fluids
    • Kajikawa O, Johnson MC, Goodman RB, Frevert CW, Martin TR. A sensitive immunoassay to detect the alpha-chemokine GRO in rabbit blood and lung fluids. J Immunol Methods. 1997;205:135-143.
    • (1997) J Immunol Methods , vol.205 , pp. 135-143
    • Kajikawa, O.1    Johnson, M.C.2    Goodman, R.B.3    Frevert, C.W.4    Martin, T.R.5
  • 32
    • 0034051869 scopus 로고    scopus 로고
    • Cell death in human lung transplantation: Apoptosis induction in human lungs during ischemia and after transplantation
    • Fischer S, Cassivi SD, Xavier AM, et al. Cell death in human lung transplantation: apoptosis induction in human lungs during ischemia and after transplantation. Ann Surg. 2000;231:424-431.
    • (2000) Ann Surg , vol.231 , pp. 424-431
    • Fischer, S.1    Cassivi, S.D.2    Xavier, A.M.3
  • 33
    • 0031752760 scopus 로고    scopus 로고
    • Apoptosis and necrosis: Mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line
    • Healy E, Dempsey M, Lally C, Ryan MP. Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line. Kidney Int. 1998;54:1955-1966.
    • (1998) Kidney Int , vol.54 , pp. 1955-1966
    • Healy, E.1    Dempsey, M.2    Lally, C.3    Ryan, M.P.4
  • 34
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods. 1991; 139:271-279.
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 35
    • 0031567916 scopus 로고    scopus 로고
    • Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement
    • Watson RW, Rotstein OD, Nathens AB, Parodo J, Marshall JC. Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement. J Immunol 1997;158:945-953.
    • (1997) J Immunol , vol.158 , pp. 945-953
    • Watson, R.W.1    Rotstein, O.D.2    Nathens, A.B.3    Parodo, J.4    Marshall, J.C.5
  • 36
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S. Apoptosis by death factor. Cell. 1997; 88:355-365.
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 37
    • 0028147053 scopus 로고
    • Acute renal failure and multiorgan failure
    • Wardle EN. Acute renal failure and multiorgan failure. Nephrol Dial Transplant. 1994;9(suppl 4): 104-107.
    • (1994) Nephrol Dial Transplant , vol.9 , Issue.SUPPL. 4 , pp. 104-107
    • Wardle, E.N.1
  • 38
    • 0035083846 scopus 로고    scopus 로고
    • Role of apoptosis of renal tubular cells in acute renal failure: Therapeutic implications
    • Rana A, Sathyanarayana P, Lieberthal W. Role of apoptosis of renal tubular cells in acute renal failure: therapeutic implications. Apoptosis. 2001;6:83-102.
    • (2001) Apoptosis , vol.6 , pp. 83-102
    • Rana, A.1    Sathyanarayana, P.2    Lieberthal, W.3
  • 39
    • 0026551591 scopus 로고
    • Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia
    • Schumer M, Colombel MC, Sawczuk IS, et al. Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol. 1992;140:831-838.
    • (1992) Am J Pathol , vol.140 , pp. 831-838
    • Schumer, M.1    Colombel, M.C.2    Sawczuk, I.S.3
  • 40
    • 0031848460 scopus 로고    scopus 로고
    • Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells
    • Ueda N, Kaushal GP, Hong X, Shah SV. Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. Kidney Int. 1998;54:399-406.
    • (1998) Kidney Int , vol.54 , pp. 399-406
    • Ueda, N.1    Kaushal, G.P.2    Hong, X.3    Shah, S.V.4
  • 41
    • 0030460595 scopus 로고    scopus 로고
    • Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia
    • Ortiz-Arduan A, Danoff TM, Kalluri R, et al. Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia. Am J Physiol. 1996;271:F1193-F1201.
    • (1996) Am J Physiol , vol.271
    • Ortiz-Arduan, A.1    Danoff, T.M.2    Kalluri, R.3
  • 42
    • 19244372627 scopus 로고    scopus 로고
    • Apoptotic cell death of vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction
    • Koide N, Abe K, Narita K, et al. Apoptotic cell death of vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction. FEMS Immunol Med Microbiol. 1996;16:205-211.
    • (1996) FEMS Immunol Med Microbiol , vol.16 , pp. 205-211
    • Koide, N.1    Abe, K.2    Narita, K.3
  • 43
    • 0033491193 scopus 로고    scopus 로고
    • CD95(APO-1/Fas)-mediated apoptosis: Live and let die
    • Krammer PH. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv Immunol. 1999;71: 163-210.
    • (1999) Adv Immunol , vol.71 , pp. 163-210
    • Krammer, P.H.1
  • 44
    • 0034890052 scopus 로고    scopus 로고
    • Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits
    • Matute-Bello G, Liles WC, Frevert CW, et al. Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits. Am J Physiol Lung Cell Mol Physiol. 2001;281:L328-L335.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281
    • Matute-Bello, G.1    Liles, W.C.2    Frevert, C.W.3
  • 45
    • 0033966777 scopus 로고    scopus 로고
    • Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome
    • Hashimoto S, Kobayashi A, Kooguchi K, et al. Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome. Am J Respir Crit Care Med. 2000; 161:237-243.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 237-243
    • Hashimoto, S.1    Kobayashi, A.2    Kooguchi, K.3
  • 46
    • 0034103813 scopus 로고    scopus 로고
    • High serum soluble Fas-ligand in cardiopulmonary arrest patients
    • Iwama H, Tohma J, Nakamura N. High serum soluble Fas-ligand in cardiopulmonary arrest patients. Am J Emerg Med. 2000;18:348.
    • (2000) Am J Emerg Med , vol.18 , pp. 348
    • Iwama, H.1    Tohma, J.2    Nakamura, N.3
  • 47
    • 0033813770 scopus 로고    scopus 로고
    • Serum soluble Fas (CD95) and Fas ligand profiles in chronic kidney failure
    • Perianayagam MC, Murray SL, Balakrishnan VS, et al. Serum soluble Fas (CD95) and Fas ligand profiles in chronic kidney failure. J Lab Clin Med. 2000; 136:320-327.
    • (2000) J Lab Clin Med , vol.136 , pp. 320-327
    • Perianayagam, M.C.1    Murray, S.L.2    Balakrishnan, V.S.3
  • 49
    • 0029026659 scopus 로고
    • The systemic inflammatory response syndrome
    • Balk RA. The systemic inflammatory response syndrome. JAMA. 1995;274:127.
    • (1995) JAMA , vol.274 , pp. 127
    • Balk, R.A.1
  • 50
    • 0034183266 scopus 로고    scopus 로고
    • Cytopathic hypoxia: A concept to explain organ dysfunction in sepsis
    • Fink MP. Cytopathic hypoxia: a concept to explain organ dysfunction in sepsis. Minerva Anestesiol. 2000;66:337-342.
    • (2000) Minerva Anestesiol , vol.66 , pp. 337-342
    • Fink, M.P.1
  • 51
    • 0033961638 scopus 로고    scopus 로고
    • Sepsis syndrome
    • Fry DE. Sepsis syndrome. Am Surg. 2000;66: 126-132.
    • (2000) Am Surg , vol.66 , pp. 126-132
    • Fry, D.E.1


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