Possible new role for NF-κB in the resolution of inflammation

Nature Medicine

Volumn 7, Issue 12, 2001, Pages 1291-1297

  Lawrence, T ^a   Gilroy, D W ^a   Colville Nash, P R ^a   Willoughby, D A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; GENE EXPRESSION REGULATION; GENE TARGETING; IMMUNOREGULATION; INFLAMMATION; NONHUMAN; PLEURISY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARRAGEENAN; CYSTEINE ENDOPEPTIDASES; FEMALE; GRANULOMA; INFLAMMATION; LEUKOCYTES; LEUPEPTINS; MALE; MICE; MULTIENZYME COMPLEXES; NF-KAPPA B; NITRILES; PLEURISY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLIDINES; RATS; SULFONES; THIOCARBAMATES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0035665020     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1201-1291     Document Type: Article

References (45)

1. Inducible cyclooxygenase may have anti-inflammatory properties
2. Lipid mediator class switching during acute inflammation: Signals in resolution
3. Apoptosis in resolution of inflammation
4. Granulocyte apoptosis and inflammatory disease
5. Phosphorylation meets ubiquitination: The control of NF-κB activity
6. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation
7. Inducible enzymes in inflammation: Advances, interactions and conflict
8. NF-κB: A key role in inflammatory diseases
9. Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer
10. Inducible nitric oxide synthase and inflammation
11. Targeted mutation of TNF-receptor I rescues the ReIA-deficient mouse and reveals a critical role for NF-κB in leukocyte recruitment
12. The Rel subunit of NF-κB-like transcription factor is a positive and negative regulator of macrophage gene expression: Distinct roles for Rel in different macrophage populations
13. Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein
14. The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects
15. Regulation of an essential innate immune response by the p50 subunit of NF-κB
16. Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-κB1) but expressing p50
17. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy
18. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
19. Direct phosphorylation of NF-κB1 p105 by the IκB kinase complex on serine 927 is essential for signal-induced p 105 proteolysis
20. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
21. 2 inhibits multiple steps in the NF-κB signaling pathway
22. Inhibition of IκB kinase and IκB phosphorylation by 15-deoxy-δ(12.14)-prostaglandin J(2) in activated murine macrophages
23. Activation of a second, evolutionarily conserved, NF-κB signaling pathway
24. The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p 50B homodimers
25. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers
26. Critical role of C/EBPδ and C/EBPβ factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1β in articular chondrocytes
27. Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages
28. Inhibition of NF-κB activation by pyrrolidine dithio-carbamate prevents in vivo expression of proinflammatory genes
29. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
30. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
31. NF-κB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type
32. Bax suppresses tumorigenesis and stimulates apoptosis in vivo
33. Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis
34. Cytokine-mediated bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammation
35. LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-α
36. The IKKβ subunit of IKκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
37. Molecular cloning and functional analysis of the murine bax gene promoter
38. NF-κB activation of p53
39. Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 expression
40. Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-κB and Myc/Max
41. 2 and PAF
42. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-β in macrophages that have iniested apoptotic cells
43. A receptor for phophatidylserine-specific clearance of apoptotic cells
44. Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages
45. 12, 14 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats