Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies

European Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2009, Pages 5055-5065

  Castro, Diego ^a   Boiani, Lucia ^a   Benitez, Diego ^a   Hernández, Paola ^a   Merlino, Alicia ^a   Gil, Carmen ^b   Olea Azar, Claudio ^c   González, Mercedes ^a   Cerecetto, Hugo ^a   Porcal, Williams ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

Free radicals; Hybrid benzofuroxans; Leishmania spp.; Mitochondrial dehydrogenases; Trypanosoma cruzi

Indexed keywords

5 [2 (ARYLTHIO)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E [2 (ARYLSULFINYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E [2 (ARYLTHIO)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E[2 (4 CHLOROPHENYLCARBONYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E[2 (4 CHLOROPHENYLSULFONYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E[2 (4 FLUOROPHENYLSULFONYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E[2 (4 FLUOROPHENYLTHIO)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E[2 (4 METHOXYPHENYLCARBONYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E[2 (4 NITROPHENYLCARBONYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5E[2 (PHENYLCARBONYL)VINYL]BENZO(1,2 C)1,2,5 OXAIAZOLE N OXIDE; 5Z [2 (ARYLSULFINYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5Z [2 (ARYLTHIO)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5Z[2 (4 CHLOROPHENYLSULFONYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5Z[2 (4 FLUOROPHENYLSULFONYL)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; 5Z[2 (4 FLUOROPHENYLTHIO)VINYL]BENZO(1,2 C) 1,2,5 OXADIAZOLE N OXIDE; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; BENZOFURAN DERIVATIVE; CRUZIPAIN; FREE RADICAL; MILTEFOSINE; NIFURTIMOX; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; IC 50; LEISHMANIA; LEISHMANIA BRAZILIENSIS; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; REDUCTION; TRYPANOSOMA CRUZI; WITTIG REACTION;

ANIMALS; BENZOXAZOLES; INHIBITORY CONCENTRATION 50; MACROPHAGES; MICE; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; OXIDATIVE STRESS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 70449685724     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.09.009     Document Type: Article

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