Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and structure-activity relationships

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 7, 2007, Pages 2768-2781

  Porcal, Williams ^a   Hernández, Paola ^a   Aguirre, Gabriela ^a   Boiani, Lucía ^a   Boiani, Mariana ^a   Merlino, Alicia ^a   Ferreira, Ana ^a   Maio, Rossanna Di ^a   Castro, Ana ^b   González, Mercedes ^a   Cerecetto, Hugo ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

Ethenylbenzofuroxans; T. cruzi; Wittig reaction

Indexed keywords

(1 HEXENYL)BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; (2 BENZOFURAZANYL)BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; (2 CYCLOHEXYLETHENYL)BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (2 NITROPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (2 THIENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (3 FLUOROPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (3,4 METHYLENDIOXYPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE; [2 (3,4 METHYLENDIOXYPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (4 ACETYLAMINO 3 NITROPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (4 BROMOPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (4 CARBOXYPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (4 CYANOPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (4 DIMETHYLAMINOPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (4 HYDROXYPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (4 METHOXYPHENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (4 PYRIDINYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (5 NITRO 2 THIENYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1 OXIDE; [2 (METHOXYCARBONYL)ETHENYL]BENZO[1,2 C] 1,2,5 OXADIAZOLE N 1OXIDE; ANTIPARASITIC AGENT; BENZOFURAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOTOXICITY; DEOXYGENATION; DRUG SCREENING; DRUG SYNTHESIS; EPIMASTIGOTE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIPOPHILICITY; MACROPHAGE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI; WITTIG REACTION;

ANIMALS; BENZOXAZOLES; CELL LINE; CELL SURVIVAL; HUMANS; INDICATORS AND REAGENTS; MACROPHAGES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA CRUZI;

EID: 33847669811     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.009     Document Type: Article

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