Heteroarylnitrones as drugs for neurodegenerative diseases: Synthesis, neuroprotective properties, and free radical scavenger properties

Journal of Medicinal Chemistry

Volumn 51, Issue 19, 2008, Pages 6150-6159

  Porcal, Williams ^a   Hernández, Paola ^a   González, Mercedes ^a   Ferreira, Ana ^b   Olea Azar, Claudio ^c   Cerecetto, Hugo ^a   Castro, Ana ^d,e  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c UNIVERSITY OF CHILE   (Chile)

^d INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^e NeuroPharma SA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 THIADIAZOLYLNITRONE DERIVATIVE; FUROXANYLNITRONE DERIVATIVE; HYDROGEN PEROXIDE; N TERT BUTYL ALPHA PHENYLNITRONE; NITRONE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DEGENERATIVE DISEASE; DRUG ACTIVITY; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; HUMAN; HUMAN CELL; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; SCAVENGING SYSTEM;

ANIMALS; BINDING SITES; CELL SURVIVAL; CYCLIC N-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; HETEROCYCLIC COMPOUNDS; HUMANS; HYDROGEN PEROXIDE; MACROPHAGES; MICE; MOLECULAR STRUCTURE; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 53549108082     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8006432     Document Type: Article

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