The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

Journal of Antimicrobial Chemotherapy

Volumn 43, Issue 6, 1999, Pages 793-803

  Zhai, Lin ^c   Chen, Ming ^c   Blom, Jens ^c   Theander, Thor G ^c   Christensen, Søren Brøgger ^a   Kharazmi, Arsalan ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHALCONE; LICOCHALCONE A; OXIDOREDUCTASE;

AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GROWTH INHIBITION; HAMSTER; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LEISHMANIASIS; LIVER; MALE; MITOCHONDRION; NONHUMAN; OXYGENATION; PARASITE; PROMASTIGOTE; SPLEEN;

ANIMALS; ANTIPROTOZOAL AGENTS; CHALCONE; CRICETINAE; DRUG EVALUATION, PRECLINICAL; HUMANS; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LEISHMANIASIS, VISCERAL; MACROPHAGES; MALE; MESOCRICETUS; MITOCHONDRIA; OXIDOREDUCTASES; RESPIRATION;

EID: 0033026925     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/43.6.793     Document Type: Article

References (15)

1. UNDP/WB/WHO (1989). The leishmaniasis. In Tropical Diseases: Progress in International Research, 1987-1988. WHO special programme for research and training in tropical diseases ninth programme report. World Health Organization, Geneva.
2. Modabber, F. (1993). Leishmaniasis. In Tropical Disease Research. Progress 1991-92. (UNDP/World Bank/WHO special programme for research and training in tropical diseases). pp. 77-87. World Health Organization, Geneva.
3. Olliaro, P. L. & Bryceson, A. D. M. (1993). Practical progress and new drugs for changing patterns of leishmaniasis. Parasitology Today 9, 323-8.
4. Alvar, J., Gutierrez-Solar, B., Pachon, I., Calbacho, E., Ramirez, M., Valles, R. et al. (1996). AIDS and Leishmania infantum: new approaches for a new epidemiological problem. Clinics in Dermatology 14, 541-6.
5. UNDP/WB/WHO. (1990). Special programme for research and training in tropical diseases (TDR). Antimonials: large-scale failure in leishmaniasis 'alarming'. TDR News 34, 1-7.
6. Chen, M., Christensen, S. B., Blom, J., Lemmich E., Nadelmann, L., Fich, K. et al. (1993). Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania. Antimicrobial Agents and Chemotherapy 37, 2550-6.
7. Chen, M., Christensen, S. B., Theander, T. G. & Kharazmi, A. (1994). Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani. Antimicrobial Agents and Chemotherapy 38, 1339-44.
8. Chen, M., Christensen, S. B., Zhai, L., Rasmussen, M. H., Theander, T. G., Frøkjaer, S. et al. (1997). The novel oxygenated chalcones, 2,4-dimethoxy-4′-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo. Journal of Infectious Diseases 176, 1327-33.
9. Zhai, L., Blom, J., Chen, M., Christensen, S. B. & Kharazmi, A. (1995). The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria. Antimicrobial Agents and Chemotherapy 39, 2742-8.
10. Doyle, P. S., Engel, J. C., Pimenta, P. F., da-Silva, P. P. & Dwyer, D.M. (1991). Leishmania donovani: long-term culture of axenic amastigotes at 37°C. Experimental Parasitology 73, 326-34.
11. Stauber, L. A., Franchino, E. M. & Grun, J. (1958). An eight-day method for screening compounds against Leishmania donovani: in the golden hamster. Journal of Protozool 5, 269-73.
12. Berg, K., Zhai, L., Kharazmi, A. & Owen, T. C. (1994). The use of a water-soluble formazan-complex to quantitate the cell number and mitochondrial function of Leishmania major promastigotes. Parasitolgy Research 80, 235-9.
13. Goijman, S. G. & Stoppani, A. O. M. (1985). Effects of β-Lapachone, a peroxide-generating quinoe, on macromolecule synthesis and degradation in Trypanosoma cruzi. Archives of Biochemistry Biophysics. 240, 273-80.
14. Pinto, A. V., Pinto, C. N., Pinto, M. C. F. R., Rita, R. S., Pezzella, C. A. C. & Castro, S. L. (1997). Trypanocidal activity of synthetic heterocyclic derivatives of active quinones from Tabebuia sp. Arzneimittel-Forshung Drug Research 47, 74-9.
15. Li, R., Kenyon, G. L., Cohen, F. E., Chen, X., Gong, B., Dominguez, J. D. et al. (1995). In vitro antimalarial activity of chalcones and their derivatives. Journal of Medical Chemistry 38, 5031-7.