Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Part 3: Substituents-clustering methodology in the search for new active compounds

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 23, 2005, Pages 6324-6335

  Aguirre, Gabriela ^a   Boiani, Lucía ^a   Cerecetto, Hugo ^a,b   Di Maio, Rossanna ^a   González, Mercedes ^a   Porcal, Williams ^a   Denicola, Ana ^b   Möller, Matías ^b   Thomson, Leonor ^b   Tórtora, Verónica ^b  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

Benzofuroxan; Hansch's series design; Mitochondrial parasite respiration; T. cruzi

Indexed keywords

(4 ACETYLAMINO 3 NITROPHENYL)METHYL TRIPHENYLPHOSPHONIUM BROMIDE; 4 (2 PHENYLETHENYL) 2 NITROANILINE; 4 BROMOMETHYL 2 NITROACETANILIDE; 4 PHENYL 2 NITROANILINE; 5 (1 HYDROXY 2 NITROETHENYL) N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 (2 NITROETHENYL) N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 (2 PHENYLETHENYL) N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 (2 PHENYLETHENYL)BENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 (2,2 DICYANOETHENYL) N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 CHLOROMETHYLBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 IODOMETHYL N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 PHENYL N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; ANTITRYPANOSOMAL AGENT; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREATHING; CHEMICAL MODIFICATION; CLUSTER ANALYSIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; IC 50; MITOCHONDRION; NONHUMAN; PARASITE; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI;

ANIMALS; BENZENE; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NIFURTIMOX; OXADIAZOLES; OXIDATION-REDUCTION; OXIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 27544490225     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.05.020     Document Type: Article

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