Development of α-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 2141-2156

  Choe, Youngchool ^a   Brinen, Linda S ^a   Price, Mark S ^a   Engel, Juan C ^b   Lange, Meinolf ^c   Grisostomi, Corinna ^c   Weston, Scott G ^c   Pallai, Peter V ^c   Cheng, Hong ^c   Hardy, Larry W ^c   Hartsough, David S ^c   McMakin, Marsha ^c   Tilton, Robert F ^c   Baldino, Carmen M ^c   Craik, Charles S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ARQULE INC   (United States)

Author keywords

Chagas disease; Cruzain; Cysteine protease inhibitors; Structure based library design

Indexed keywords

2 OXOACID; A 840165; AMIDE; AQ 573188; AQ 581332; AQ 616475; AQ 616476; AQ 625172; AQ 625173; AQ 665183; AQ 665184; AQ 713492; AQ 718038; AQ 718041; AQ 722431; AQ 729376; AQ 752489; AQ 797526; AQ 840158; AQ 840159; AQ 840160; AQ 840161; AQ 840162; AQ 840163; AQ 840164; AQ 840166; AQ 903077; AQ 903078; AQ 903079; AQ 903080; AQ 903081; AQ 903082; AQ 903083; AQ 903084; AQ 903085; AQ 903086; AQ 903087; AQ 903088; AQ 903089; AQ 903090; AQ 903091; CRUZIPAIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ENZYME INHIBITOR; ESTER DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL CULTURE; CHAGAS DISEASE; COVALENT BOND; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 13844308925     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.12.053     Document Type: Article

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