Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential antiprotozoal drugs

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

Volumn 59, Issue 1, 2003, Pages 69-74

  Olea Azar, C ^a   Rigol, Carolina ^a   Mendizábal, Fernando ^a   Briones, R ^a   Cerecetto, Hugo ^b   Di Maio, Rossana ^b   Risso, Mariela ^b   González, Mercedes ^b   Porcal, Williams ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

ADF; Cyclic voltammetry; ESR; Microsome; N oxide derivates anion radical; T. cruzi

Indexed keywords

CYCLIC VOLTAMMETRY; DRUG PRODUCTS; ELECTROCHEMISTRY; ELECTROLYTIC REDUCTION; ELECTRON SPIN RESONANCE SPECTROSCOPY; MOLECULAR ORIENTATION; PROBABILITY DENSITY FUNCTION;

ANTIPROTOZOAL DRUGS;

FREE RADICALS;

ANTIPROTOZOAL AGENT; FREE RADICAL; OXADIAZOLE DERIVATIVE;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE; METHODOLOGY; MICROSOME;

ANTIPROTOZOAL AGENTS; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; MICROSOMES; MODELS, CHEMICAL; OXADIAZOLES;

EID: 0037207595     PISSN: 13861425     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-1425(02)00141-5     Document Type: Article

References (14)

1. Brener Z. Pharmacol. Ther. 7:1979;71.
2. Messender J.C., Tinocco L., Figueroa-Villar J.D., Souza E.M., Santa Rita R., de Castro S.L. Bioorg. Med. Chem. Lett. 5:1995;3079.
3. Hazra B., Sur P., Sur B., Banerjee A., Roy D.K. Planta Med. 51:1984;295.
4. Morello A., Pavani M., Garbarino J.A., Chamy M.C., Frey C., Mancilla J., Guerrero A., Repetto Y., Ferreira J. Comp. Biochem. Physiol. 112C:1995;119.
5. Docampo R., Moreno S.N.J. Rev. Infect. Dis. 6:1984;223.
6. Olea-Azar C., Atrua A., di Maio R., Seaone G., Cerecetto H. Spectrosc. Letts. 31:1998;849.
7. Olea-Azar C., Atria A.-M., Mendizabal F., di Maio R., Seoane G., Cerecetto H. Spectrosc. Letts. 31:1998;99.
8. Cahill A., White I.N. Biochem. Soc. Trans. 19:1991;1275.
9. J.M. Brown, Redox activation of benzotriazine N-oxides: mechanisms and potential as anticancer drugs, In: Selective Activation of Drugs by Redox Processes, Plenum Press, Fermo, Italy, pp. 137-148.
10. Monge A., Lopez de Cearin A., Díaz E., di Maio R., Gonzalez M., Onetto S., Seaone G., Cerecetto H., Olea-Azar C. J. Med. Chem. 42:1999;1941.
11. M.J. Risch, G.W. Trucks, H.B. Schlegel, P.N.W. Gill, B.G. Johnson, M.A. Robb, J.R. Cheeseman, K.T. Keith, G.A. Petersson, J.A. Montgomery, K. Raghavachari, M.A. Al-Laham, V.G. Zakrzewski, J.V. Ortiz, J.B. Foresman, J. Cioslowski, B.B. Stefanov, A. Nanayakkara, M. Challacombe, C.Y. Peng, P.Y. Ayala, W. Chen, M.W. Wong, J.L. Andres, E.S. Replogle, R. Gomperts, R.L. Martin, D.J. Fox, J.S. Binkley, D.J. Defrees, J. Baker, J.P. Stewart, M. Head-Gordon, C. Gonzalez, J.A. Pople, Gaussian '98, Rev. A.7, Inc., Pittsburgh, PA, 1998.
12. Vosko S.H., Wilk L. J. Phys. Chem. B16:1983;3687.
13. Perdew J. Phys. Rev. B33:1984;8822.
14. Nicholson R., Shain I. Anal. Chem. 36:1964;706.