The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

Nature

Volumn 428, Issue 6980, 2004, Pages 328-332

  Garkavtsev, Igor ^a   Kozin, Sergey V ^a   Chernova, Olga ^b   Xu, Lei ^a   Winkler, Frank ^a   Brown, Edward ^a   Barnett, Gene H ^b   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; BRAIN; GENES; GRAFTS; TUMORS;

ANGIOGENESIS; TUMOR GROWTH;

PROTEINS;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ING4 PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CYCLOOXYGENASE 2; HOMEODOMAIN PROTEIN; ING4 PROTEIN, HUMAN; INTERLEUKIN 6; INTERLEUKIN 8; ISOENZYME; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE; PTGS2 PROTEIN, HUMAN;

MEDICINE;

ANGIOGENESIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CANCER CELL CULTURE; CANCER GRADING; CELL STRAIN U87MG; CONTROLLED STUDY; GENE EXPRESSION; GENE REPRESSION; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; ING4 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SCID MOUSE; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CELL DIVISION; DISEASE COURSE; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; GLIOBLASTOMA; METABOLISM; MOUSE MUTANT; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROTEIN BINDING; TUMOR CELL LINE; VASCULARIZATION;

ANIMALIA;

ANIMALS; BRAIN NEOPLASMS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; CYCLOOXYGENASE 2; DISEASE PROGRESSION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; ISOENZYMES; MEMBRANE PROTEINS; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; TRANSCRIPTION FACTOR RELA; TUMOR SUPPRESSOR PROTEINS;

EID: 1642586297     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02329     Document Type: Article

References (25)

1. Maher, E. A. et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev. 15, 1311-1333 (2001).
2. Plate, K. H. & Risau, W. Angiogenesis in malignant gliomas. Glia 15, 339-347 (1995).
3. Kerbel, R. & Folkman, J. Clinical translation of angiogenesis inhibitors. Nature Rev. Cancer 2, 727-739 (2002).
4. Carmeliet, P. & Jain, R. K. Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000).
5. Van Meir, E. G. et al. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nature Genet. 8, 171-176 (1994).
6. Dameron, K. M., Volpert, O. V., Tainsky, M. A. & Bouck, N. Control of angiogenesis in fibroblasts by p53 regulation of trombospondin-1. Science 265, 1582-1584 (1994).
7. ING1 promotes neoplastic transformation. Nature Genet. 14, 415-420 (1996).
8. ING1 candidate tumour suppressor. Mol. Cell. Biol. 17, 2014-2019 (1997).
9. ING1 cooperates with p53 in cell growth control. Nature 391, 295-298 (1998).
10. ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res. 63, 2373-2378 (2003).
11. Skowyra, D. et al. Differential association of products of alternative transcripts of the candidate tumour suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. J. Biol. Chem. 276, 8734-8739 (2001).
12. Nourani, A. et al. Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol. Cell. Biol. 21, 7629-7640 (2001).
13. Leung, K. M. et al. The candidate tumour suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2. Cancer Res. 62, 4890-4893 (2002).
14. Toyama, T. et al. Suppression of ING1 expression in sporadic breast cancer. Oncogene 18, 5187-5193 (1999).
15. ING1 and the relationship with p53 expression in human gastric cancer. Cancer Lett. 147, 157-162 (1999).
16. Chen, B., Campos, E. I., Crawford, R., Martinka, M. & Li, G. Analyses of the tumour suppressor ING1 expression and gene mutation in human basal cell carcinoma. Int. J. Oncol. 22, 927-931 (2003).
17. Gunduz, M. et al. Genomic structure of the human ING1 gene and tumour-specific mutations detected in head and neck squamous cell carcinomas. Cancer Res. 60, 3143-3146 (2000).
18. Brat, D. J., Castellano-Sanchez, A., Kaur, B. & Van Meir, E. G. Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation. Adv. Anat. Pathol. 9, 24-36 (2002).
19. Kleihues, P. et al. The WHO classification of tumours of the nervous system. J. Neuropathol. Exp. Neurol. 61, 215-225 (2002).
20. Jain, R. K., Munn, L. L. & Fukumura, D. Dissecting tumour pathophysiology using intravital microscopy. Nature Rev. Cancer 2, 266-276 (2002).
21. Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell 109 (suppl.), S81-S96 (2002).
22. Karin, M., Cao, Y., Greten, F. R. & Li, Z. W. NF-κB in cancer: from innocent bystander to major culprit. Nature Rev. Cancer 2, 301-310 (2002).
23. Desbaillets, I., Diserens, A. C., de Tribolet, N., Hamou, M. F. & Van Meir, E. G. Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma. Oncogene 18, 1447-1456 (1999).
24. Desbaillets, I., Diserens, A. C., Tribolet, N., Hamou, M. F. & Van Meir, E. G. Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J. Exp. Med. 186, 1201-1212 (1997).
25. Xu, L., Xie, K., Mukaida, N., Matsushima, K. & Fidler, I. J. Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells. Cancer Res. 59, 5822-5829 (1999).