Selective introduction of antisense oligonucleotides into single adult CNS progenitor cells using electroporation demonstrates the requirement of STAT3 activation for CNTF-induced gliogenesis

Molecular and Cellular Neuroscience

Volumn 17, Issue 3, 2001, Pages 426-443

  Åberg, Maria A I ^a   Ryttsén, Frida ^b   Hellgren, Gunnel ^a   Lindell, Kajsa ^a   Rosengren, Lars E ^a   MacLennan, A John ^c   Carlsson, Björn ^a   Orwar, Owe ^b   Eriksson, Peter S ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CILIARY NEUROTROPHIC FACTOR; COMPLEMENTARY DNA; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; STAT3 PROTEIN;

ADULT; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; ELECTROPORATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LABORATORY TEST; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL;

EID: 0035071413     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.2000.0947     Document Type: Article

References (62)

1. Genistein, a specific inhibitor of tyrosine-specific protein kinases
2. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
3. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
4. Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatum
5. Increase in glia-derived nerve growth factor following destruction of hippocampal neurons
6. Gliosis
7. Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus
8. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
9. Expression of mRNA for glial fibrillary acidic protein after experimental cerebral injury
10. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
11. Ciliary neurotrophic factor stimulates the expression of glial fibrillary acidic protein by brain astrocytes in vivo
12. The molecular biology of the CNTF receptor
13. Oligodendroglial survival factors, PDGF-AA and CNTF, activate similar JAK/STAT signaling pathways
14. Novel cationic amphiphiles as delivery agents for antisense oligonucleotides
15. Basic fibroblast growth factor (bFGF) injection activates the glial reaction in the injured adult rat brain
16. Neurogenesis in the adult human hippocampus
17. Chronic encephalitis associated with epilepsy: Immunochemical and ultrastructural studies
18. Monoclonal antibody A2B5 reacts with many gangliosides in neuronal tissue
19. Antisense inhibitory effect: A comparison between 3′-partial and full phosphorothioate antisense oligonucleotides
20. Interleukin-1 stimulation of astroglial proliferation after brain injury
21. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
22. Ciliary neurotrophic factor stimulates astroglial hypertrophy in vivo and in vitro
23. Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture
24. The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development
25. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
26. Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain
27. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system
28. Ciliary neurotrophic factor activates JAK/Stat signal transduction cascade and induces transcriptional expression of glial fibrillary acidic protein in glial cells
29. Sequence of a rat TIS11 cDNA, an immediate early gene induced by growth factors and phorbol esters
30. Quantitative and qualitative alterations of neuronal and glial intermediate filaments in rat nervous system after exposure to 2,5-hexanedione
31. Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor
32. Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor alpha expression in astrocytes and neurons of the fascia dentata after entorhinal cortex lesion
33. Transient up-regulation of ciliary neurotrophic factor receptor-alpha mRNA in axotomized rat septal neurons
34. Acute exposure to CNTF in vivo induces multiple components of reactive gliosis
35. Extracellular matrix-associated molecules collaborate with ciliary neurotrophic factor to induce type-2 astrocyte development
36. Phenotypic alteration of astrocytes induced by ciliary neurotrophic factor in the intact adult brain, As revealed by adenovirus-mediated gene transfer
37. Altering the biochemical state of individual cultured cells and organelles with ultramicroelectrodes
38. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
39. Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system
40. Neurological lineages and neurological diseases
41. Early cortical precursors do not undergo LIF-mediated astrocytic differentiation
42. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
43. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells
44. Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation
45. Changes in expression of ciliary neurotrophic factor (CNTF) and CNTF-receptor alpha after spinal cord injury
46. The adult rat hippocampus contains primordial neural stem cells
47. Multiple routes to astrocytic differentiation in the CNS
48. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
49. Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF
50. A sensitive ELISA for glial fibrillary acidic protein: Application in CSF of adults
51. Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines
52. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus
53. Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid
54. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
55. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
56. Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections
57. Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain
58. STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines
59. Intracellular signalling: Putting JAKs on the kinase MAP
60. A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury
61. Increase of extracellular insulin-like growth factor I (IGF-I) concentration following electrolytical lesion in rat hippocampus
62. Cytokines affecting survival and differentiation of an astrocyte progenitor cell line