-
1
-
-
45349096041
-
-
American Cancer Society. Atlanta, GA: American Cancer Society, Inc
-
American Cancer Society. Cancer Facts and Figures 2008. Atlanta, GA: American Cancer Society, Inc., 2008.
-
(2008)
Cancer Facts and Figures 2008
-
-
-
2
-
-
0141864377
-
Apoptosis, chemoresistance, and breast cancer: Insights from the MCF-7 cell model system
-
Simstein R, Burow M, Parker A, Weldon C, Beckman B. Apoptosis, chemoresistance, and breast cancer: insights from the MCF-7 cell model system. Exp Biol Med (Maywood) 228:995-1003, 2003. (Pubitemid 37222167)
-
(2003)
Experimental Biology and Medicine
, vol.228
, Issue.9
, pp. 995-1003
-
-
Simstein, R.1
Burow, M.2
Parker, A.3
Weldon, C.4
Beckman, B.5
-
3
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev 9:139-150, 2008.
-
(2008)
Nat Rev
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
4
-
-
38549093011
-
Lipid signalling in disease
-
Wymann MP, Schneiter R. Lipid signalling in disease. Nat Rev 9:162-176, 2008.
-
(2008)
Nat Rev
, vol.9
, pp. 162-176
-
-
Wymann, M.P.1
Schneiter, R.2
-
5
-
-
0037135626
-
The c-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
-
Hannun YA, Obeid LM. The c-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 277:25847-25850, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 25847-25850
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
6
-
-
0033792671
-
Effects of sphingosine and other sphingolipids on protein kinase C
-
Smith ER, Merrill AH, Obeid LM, Hannun YA. Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol 312: 361-373, 2000. (Pubitemid 30794092)
-
(2000)
Methods in Enzymology
, vol.312
, pp. 361-373
-
-
Smith, E.R.1
Merrill Jr., A.H.2
Obeid, L.M.3
Hannun, Y.A.4
-
7
-
-
3242696730
-
Physiological and pathological actions of sphingosine 1-phosphate
-
DOI 10.1016/j.semcdb.2004.05.002, PII S1084952104000667
-
Hla T. Physiological and pathological actions of sphingosine 1- phosphate. Semin Cell Dev Biol 15:513-520, 2004. (Pubitemid 38953947)
-
(2004)
Seminars in Cell and Developmental Biology
, vol.15
, Issue.5
, pp. 513-520
-
-
Hla, T.1
-
8
-
-
0036773971
-
FTY720: Targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
-
Brinkmann V, Lynch KR. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr Opin Immunol 14:569-575, 2002.
-
(2002)
Curr Opin Immunol
, vol.14
, pp. 569-575
-
-
Brinkmann, V.1
Lynch, K.R.2
-
9
-
-
0036205659
-
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients
-
Budde K, Schmouder RL, Brunkhorst R, Nashan B, Lucker PW, Mayer T, Choudhury S, Skerjanec A, Kraus G, Neumayer HH. First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J Am Soc Nephrol 13:1073-1083, 2002. (Pubitemid 34274106)
-
(2002)
Journal of the American Society of Nephrology
, vol.13
, Issue.4
, pp. 1073-1083
-
-
Budde, K.1
Schmouder, R.L.2
Brunkhorst, R.3
Nashan, B.4
Lucker, P.W.5
Mayer, T.6
Choudhury, S.7
Skerjanec, A.8
Kraus, G.9
Neumayer, H.H.10
-
10
-
-
42649146192
-
New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets
-
Huwiler A, Pfeilschifter J. New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets. Biochem Pharmacol 75: 1893-1900, 2008.
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 1893-1900
-
-
Huwiler, A.1
Pfeilschifter, J.2
-
11
-
-
33750456153
-
Targeting sphingosine-1-phosphate for cancer therapy
-
Sabbadini RA. Targeting sphingosine-1-phosphate for cancer therapy. Br J Cancer 95:1131-1135, 2006.
-
(2006)
Br J Cancer
, vol.95
, pp. 1131-1135
-
-
Sabbadini, R.A.1
-
12
-
-
2442699980
-
Sphingosine-1-phosphate receptors: Receptor specificity versus functional redundancy
-
Taha TA, Argraves KM, Obeid LM. Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta 1682:48-55, 2004.
-
(2004)
Biochim Biophys Acta
, vol.1682
, pp. 48-55
-
-
Taha, T.A.1
Argraves, K.M.2
Obeid, L.M.3
-
14
-
-
0142056955
-
Sphingosine kinase transmits estrogen signaling in human breast cancer cells
-
Sukocheva OA, Wang L, Albanese N, Pitson SM, Vadas MA, Xia P. Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Mol Endocrinol 17:2002-2012, 2003.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 2002-2012
-
-
Sukocheva, O.A.1
Wang, L.2
Albanese, N.3
Pitson, S.M.4
Vadas, M.A.5
Xia, P.6
-
15
-
-
0036436697
-
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells
-
DOI 10.1006/excr.2002.5658
-
Nava VE, Hobson JP, Murthy S, Milstien S, Spiegel S. Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp Cell Res 281:115-127, 2002. (Pubitemid 35373788)
-
(2002)
Experimental Cell Research
, vol.281
, Issue.1
, pp. 115-127
-
-
Nava, V.E.1
Hobson, J.P.2
Murthy, S.3
Milstien, S.4
Spiegel, S.5
-
16
-
-
25844457390
-
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
-
DOI 10.1016/j.febslet.2005.08.055, PII S0014579305010677
-
Sarkar S, Maceyka M, Hait NC, Paugh SW, Sankala H, Milstien S, Spiegel S. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett 579: 5313-5317, 2005. (Pubitemid 41395149)
-
(2005)
FEBS Letters
, vol.579
, Issue.24
, pp. 5313-5317
-
-
Sarkar, S.1
Maceyka, M.2
Hait, N.C.3
Paugh, S.W.4
Sankala, H.5
Milstien, S.6
Spiegel, S.7
-
17
-
-
52949143502
-
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
-
Ruckhaberle E, Rody A, Engels K, Gaetje R, von Minckwitz G, Schiffmann S, Grosch S, Geisslinger G, Holtrich U, Karn T, Kaufmann M. Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res Treat 112:41-52, 2008.
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 41-52
-
-
Ruckhaberle, E.1
Rody, A.2
Engels, K.3
Gaetje, R.4
Von Minckwitz, G.5
Schiffmann, S.6
Grosch, S.7
Geisslinger, G.8
Holtrich, U.9
Karn, T.10
Kaufmann, M.11
-
18
-
-
33750509678
-
Sphingosine kinase-1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease
-
DOI 10.1016/j.febslet.2006.09.070, PII S0014579306011987
-
Taha TA, El-Alwani M, Hannun YA, Obeid LM. Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease. FEBS Lett 580:6047-6054, 2006. (Pubitemid 44666785)
-
(2006)
FEBS Letters
, vol.580
, Issue.26
, pp. 6047-6054
-
-
Taha, T.A.1
El-Alwani, M.2
Hannun, Y.A.3
Obeid, L.M.4
-
19
-
-
0033118475
-
Apoptosis, p53, and tumor cell sensitivity to anticancer agents
-
Brown JM, Wouters BG. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 59:1391-1399, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 1391-1399
-
-
Brown, J.M.1
Wouters, B.G.2
-
22
-
-
0031863732
-
Use of cellular and cytokine adjuvants in the immunotherapy of cancer
-
Salgaller ML, Lodge PA. Use of cellular and cytokine adjuvants in the immunotherapy of cancer. J Surg Oncol 68:122-138, 1998.
-
(1998)
J Surg Oncol
, vol.68
, pp. 122-138
-
-
Salgaller, M.L.1
Lodge, P.A.2
-
23
-
-
0027196547
-
Control of programmed cell death in normal and leukemic cells: New implications for therapy
-
Sachs L, Lotem J. Control of programmed cell death in normal and leukemic cells: new implications for therapy. Blood 82:15-21, 1993. (Pubitemid 23188740)
-
(1993)
Blood
, vol.82
, Issue.1
, pp. 15-21
-
-
Sachs, L.1
Lotem, J.2
-
24
-
-
33644778549
-
Laser microdissection and microarray analysis of breast tumors reveal ER-alpha related genes and pathways
-
DOI 10.1038/sj.onc.1209165, PII 1209165
-
Yang F, Foekens JA, Yu J, Sieuwerts AM, Timmermans M, Klijn JG, Atkins D, Wang Y, Jiang Y. Laser microdissection and microarray analysis of breast tumors reveal ER-alpha related genes and pathways. Oncogene 25:1413-1419, 2006. (Pubitemid 43336470)
-
(2006)
Oncogene
, vol.25
, Issue.9
, pp. 1413-1419
-
-
Yang, F.1
Foekens, J.A.2
Yu, J.3
Sieuwerts, A.M.4
Timmermans, M.5
Klijn, J.G.M.6
Atkins, D.7
Wang, Y.8
Jiang, Y.9
-
25
-
-
37849022459
-
Identification of key processes underlying cancer phenotypes using biologic pathway analysis
-
Efroni S, Schaefer CF, Buetow KH. Identification of key processes underlying cancer phenotypes using biologic pathway analysis. PLoS One 2:e425, 2007.
-
(2007)
PLoS One
, vol.2
-
-
Efroni, S.1
Schaefer, C.F.2
Buetow, K.H.3
-
26
-
-
0033061705
-
The Fas/Fas-ligand system: A mechanism for immune evasion in human breast carcinomas
-
DOI 10.1023/A:1006102601215
-
Gutierrez LS, Eliza M, Niven-Fairchild T, Naftolin F, Mor G. The Fas/Fas-ligand system: a mechanism for immune evasion in human breast carcinomas. Breast Cancer Res Treat 54:245-253, 1999. (Pubitemid 29322347)
-
(1999)
Breast Cancer Research and Treatment
, vol.54
, Issue.3
, pp. 245-253
-
-
Gutierrez, L.S.1
Eliza, M.2
Niven-Fairchild, T.3
Naftolin, F.4
Mor, G.5
-
27
-
-
34447100140
-
Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer
-
DOI 10.1093/carcin/bgl250
-
Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D. Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer. Carcinogenesis 28:1067-1073, 2007. (Pubitemid 47072192)
-
(2007)
Carcinogenesis
, vol.28
, Issue.5
, pp. 1067-1073
-
-
Zhang, B.1
Sun, T.2
Xue, L.3
Han, X.4
Zhang, B.5
Lu, N.6
Shi, Y.7
Tan, W.8
Zhou, Y.9
Zhao, D.10
Zhang, X.11
Guo, Y.12
Lin, D.13
-
28
-
-
33644803764
-
Dexamethasone protection from TNF-alpha-induced cell death in MCF-7 cells requires NF-kappaB and is independent from AKT
-
DOI 10.1186/1471-2121-7-9
-
Machuca C, Mendoza-Milla C, Cordova E, Mejia S, Covarrubias L, Ventura J, Zentella A. Dexamethasone protection from TNF-alpha-induced cell death in MCF-7 cells requires NF-kappaB and is independent from AKT. BMC Cell Biol 7:9, 2006. (Pubitemid 43349669)
-
(2006)
BMC Cell Biology
, vol.7
, pp. 9
-
-
Machuca, C.1
Mendoza-Milla, C.2
Cordova, E.3
Mejia, S.4
Covarrubias, L.5
Ventura, J.6
Zentella, A.7
-
29
-
-
40349088906
-
Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy- Induced cytotoxicity
-
Redondo M, Tellez T, Roldan MJ, Serrano A, Garcia-Aranda M, Gleave ME, Hortas ML, Morell M. Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy- induced cytotoxicity. Breast Cancer Res 9:R86, 2007.
-
(2007)
Breast Cancer Res
, vol.9
-
-
Redondo, M.1
Tellez, T.2
Roldan, M.J.3
Serrano, A.4
Garcia-Aranda, M.5
Gleave, M.E.6
Hortas, M.L.7
Morell, M.8
-
30
-
-
0028129435
-
Regulation of c-jun expression during hypoxic and low-glucose stress
-
Ausserer WA, Bourrat-Floeck B, Green CJ, Laderoute KR, Sutherland RM. Regulation of c-jun expression during hypoxic and low-glucose stress. Mol Cell Biol 14:5032-5042, 1994. (Pubitemid 24235931)
-
(1994)
Molecular and Cellular Biology
, vol.14
, Issue.8
, pp. 5032-5042
-
-
Ausserer, W.A.1
Bourrat-Floeck, B.2
Green, C.J.3
Laderoute, K.R.4
Sutherland, R.M.5
-
31
-
-
34948853738
-
Tumor cell apoptosis polarizes macrophages - Role of sphingosine-1- phosphate
-
DOI 10.1091/mbc.E06-12-1096
-
Weigert A, Tzieply N, von Knethen A, Johann AM, Schmidt H, Geisslinger G, Brune B. Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. Mol Biol Cell 18:3810-3819, 2007. (Pubitemid 47519475)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.10
, pp. 3810-3819
-
-
Weigert, A.1
Tzieply, N.2
Von Knethen, A.3
Johann, A.M.4
Schmidt, H.5
Geisslinger, G.6
Brune, B.7
-
32
-
-
54249088951
-
Sphingosine kinase 1: A new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells
-
Ader I, Brizuela L, Bouquerel P, Malavaud B, Cuvillier O. Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells. Cancer Res 68:8635-8642, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 8635-8642
-
-
Ader, I.1
Brizuela, L.2
Bouquerel, P.3
Malavaud, B.4
Cuvillier, O.5
-
33
-
-
33644990327
-
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase
-
Li Q, Engelhardt JF. Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem 281:1495-1505, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 1495-1505
-
-
Li, Q.1
Engelhardt, J.F.2
-
34
-
-
33845291120
-
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
-
DOI 10.1016/j.bbamem.2006.08.007, PII S0005273606003130, Sphingolipids, Apoptosis and Disease
-
Hait NC, Oskeritzian CA, Paugh SW, Milstien S, Spiegel S. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim Biophys Acta 1758:2016-2026, 2006. (Pubitemid 44879368)
-
(2006)
Biochimica et Biophysica Acta - Biomembranes
, vol.1758
, Issue.12
, pp. 2016-2026
-
-
Hait, N.C.1
Oskeritzian, C.A.2
Paugh, S.W.3
Milstien, S.4
Spiegel, S.5
-
35
-
-
33749051213
-
Can NF-kappaB be a target for novel and efficient anti-cancer agents?
-
Olivier S, Robe P, Bours V. Can NF-kappaB be a target for novel and efficient anti-cancer agents? Biochem Pharmacol 72:1054-1068, 2006.
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 1054-1068
-
-
Olivier, S.1
Robe, P.2
Bours, V.3
-
36
-
-
0034906909
-
NF-kappaB-mediated chemoresistance in breast cancer cells
-
DOI 10.1067/msy.2001.115512
-
Weldon CB, Burow ME, Rolfe KW, Clayton JL, Jaffe BM, Beckman BS. NF-kappa B-mediated chemoresistance in breast cancer cells. Surgery 130:143-150, 2001. (Pubitemid 32721661)
-
(2001)
Surgery
, vol.130
, Issue.2
, pp. 143-150
-
-
Weldon, C.B.1
Burow, M.E.2
Rolfe, K.W.3
Clayton, J.L.4
Jaffe, B.M.5
Beckman, B.S.6
-
37
-
-
15944425766
-
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria
-
DOI 10.1042/BJ20041627
-
Birbes H, Luberto C, Hsu YT, El Bawab S, Hannun YA, Obeid LM. A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J 386:445-451, 2005. (Pubitemid 40445868)
-
(2005)
Biochemical Journal
, vol.386
, Issue.3
, pp. 445-451
-
-
Birbes, H.1
Luberto, C.2
Hsu, Y.-T.3
El Bawab, S.4
Hannun, Y.A.5
Obeid, L.M.6
-
38
-
-
33745094348
-
Activation of nuclear factor-kappa B is linked to resistance to neoadjuvant chemotherapy in breast cancer patients
-
DOI 10.1677/erc.1.01171
-
Montagut C, Tusquets I, Ferrer B, Corominas JM, Bellosillo B, Campas C, Suarez M, Fabregat X, Campo E, Gascon P, Serrano S, Fernandez PL, Rovira A, Albanell J. Activation of nuclear factor-kappa B is linked to resistance to neoadjuvant chemotherapy in breast cancer patients. Endocr Relat Cancer 13:607-616, 2006. (Pubitemid 43886680)
-
(2006)
Endocrine-Related Cancer
, vol.13
, Issue.2
, pp. 607-616
-
-
Montagut, C.1
Tusquets, I.2
Ferrer, B.3
Corominas, J.M.4
Bellosillo, B.5
Campas, C.6
Suarez, M.7
Fabregat, X.8
Campo, E.9
Gascon, P.10
Serrano, S.11
Fernandez, P.L.12
Rovira, A.13
Albanell, J.14
-
39
-
-
18544396176
-
Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780)
-
Gu Z, Lee RY, Skaar TC, Bouker KB, Welch JN, Lu J, Liu A, Zhu Y, Davis N, Leonessa F, Brunner N, Wang Y, Clarke R. Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780). Cancer Res 62:3428-3437, 2002. (Pubitemid 34651389)
-
(2002)
Cancer Research
, vol.62
, Issue.12
, pp. 3428-3437
-
-
Gu, Z.1
Lee, R.Y.2
Skaar, T.C.3
Bouker, K.B.4
Welch, J.N.5
Lu, J.6
Liu, A.7
Zhu, Y.8
Davis, N.9
Leonessa, F.10
Brunner, N.11
Wang, Y.12
Clarke, R.13
-
40
-
-
34247242607
-
Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer
-
DOI 10.1186/1471-2407-7-59
-
Zhou Y, Yau C, Gray JW, Chew K, Dairkee SH, Moore DH, Eppenberger U, Eppenberger-Castori S, Benz CC. Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer. BMC Cancer 7:59, 2007. (Pubitemid 46614509)
-
(2007)
BMC Cancer
, vol.7
, pp. 59
-
-
Zhou, Y.1
Yau, C.2
Gray, J.W.3
Chew, K.4
Dairkee, S.H.5
Moore, D.H.6
Eppenberger, U.7
Eppenberger-Castori, S.8
Benz, C.C.9
-
41
-
-
13944282293
-
The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells
-
Riggins RB, Zwart A, Nehra R, Clarke R. The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)- induced apoptosis in antiestrogen-resistant breast cancer cells. Mol Cancer Ther 4:33-41, 2005. (Pubitemid 40268064)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.1
, pp. 33-41
-
-
Riggins, R.B.1
Zwart, A.2
Nehra, R.3
Clarke, R.4
-
42
-
-
3543018495
-
Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer
-
Curry EA 3rd, Murry DJ, Yoder C, Fife K, Armstrong V, Nakshatri H, O'Connell M, Sweeney CJ. Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Invest New Drugs 22:299-305, 2004.
-
(2004)
Invest New Drugs
, vol.22
, pp. 299-305
-
-
Curry III, E.A.1
Murry, D.J.2
Yoder, C.3
Fife, K.4
Armstrong, V.5
Nakshatri, H.6
O'Connell, M.7
Sweeney, C.J.8
-
43
-
-
46949104885
-
"Inside-out" signaling of sphingosine-1-phosphate: Therapeutic targets
-
Takabe K, Paugh SW, Milstien S, Spiegel S. "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 60:181-195, 2008.
-
(2008)
Pharmacol Rev
, vol.60
, pp. 181-195
-
-
Takabe, K.1
Paugh, S.W.2
Milstien, S.3
Spiegel, S.4
-
44
-
-
38849091433
-
Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
-
DOI 10.1158/0008-5472.CAN-07-2707
-
Massarweh S, Osborne CK, Creighton CJ, Qin L, Tsimelzon A, Huang S, Weiss H, Rimawi M, Schiff R. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res 68:826-833, 2008. (Pubitemid 351206760)
-
(2008)
Cancer Research
, vol.68
, Issue.3
, pp. 826-833
-
-
Massarweh, S.1
Osborne, C.K.2
Creighton, C.J.3
Qin, L.4
Tsimelzon, A.5
Huang, S.6
Weiss, H.7
Rimawi, M.8
Schiff, R.9
-
45
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
Shou J, Massarweh S, Osborne CK, Wakeling AE, Ali S, Weiss H, Schiff R. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 96:926-935, 2004. (Pubitemid 38868139)
-
(2004)
Journal of the National Cancer Institute
, vol.96
, Issue.12
, pp. 926-935
-
-
Shou, J.1
Massarweh, S.2
Osborne, C.K.3
Wakeling, A.E.4
Ali, S.5
Weiss, H.6
Schiff, R.7
-
46
-
-
26844556553
-
GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways
-
DOI 10.1515/BC.2005.099
-
Hart S, Fischer OM, Prenzel N, Zwick-Wallasch E, Schneider M, Hennighausen L, Ullrich A. GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways. Biol Chem 386:845-855, 2005. (Pubitemid 41448140)
-
(2005)
Biological Chemistry
, vol.386
, Issue.9
, pp. 845-855
-
-
Hart, S.1
Fischer, O.M.2
Prenzel, N.3
Zwick-Wallasch, E.4
Schneider, M.5
Hennighausen, L.6
Ullrich, A.7
-
47
-
-
33646117016
-
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: The role of sphingosine kinase-1
-
Sukocheva O, Wadham C, Holmes A, Albanese N, Verrier E, Feng F, Bernal A, Derian CK, Ullrich A, Vadas MA, Xia P. Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. J Cell Biol 173:301-310, 2006.
-
(2006)
J Cell Biol
, vol.173
, pp. 301-310
-
-
Sukocheva, O.1
Wadham, C.2
Holmes, A.3
Albanese, N.4
Verrier, E.5
Feng, F.6
Bernal, A.7
Derian, C.K.8
Ullrich, A.9
Vadas, M.A.10
Xia, P.11
-
48
-
-
0037241504
-
Integration of signal transduction inhibitors with endocrine therapy: An approach to overcoming hormone resistance in breast cancer
-
Johnston SR, Head J, Pancholi S, Detre S, Martin LA, Smith IE, Dowsett M. Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer. Clin Cancer Res 9:524S-532S, 2003. (Pubitemid 36105797)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.1 II
-
-
Johnston, S.R.D.1
Head, J.2
Pancholi, S.3
Detre, S.4
Martin, L.-A.5
Smith, I.E.6
Dowsett, M.7
-
49
-
-
0037009820
-
Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts
-
Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA, Bissell MJ. Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst 94:1494-1503, 2002. (Pubitemid 35243746)
-
(2002)
Journal of the National Cancer Institute
, vol.94
, Issue.19
, pp. 1494-1503
-
-
Wang, F.1
Hansen, R.K.2
Radisky, D.3
Yoneda, T.4
Barcellos-Hoff, M.H.5
Petersen, O.W.6
Turley, E.A.7
Bissell, M.J.8
-
50
-
-
33748668261
-
Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line
-
DOI 10.1186/1471-2407-6-213
-
Fiebig AA, Zhu W, Hollerbach C, Leber B, Andrews DW. Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line. BMC Cancer 6:213, 2006. (Pubitemid 44382756)
-
(2006)
BMC Cancer
, vol.6
, pp. 213
-
-
Fiebig, A.A.1
Zhu, W.2
Hollerbach, C.3
Leber, B.4
Andrews, D.W.5
-
51
-
-
0032574761
-
Bax directly induces release of cytochrome c from isolated mitochondria
-
DOI 10.1073/pnas.95.9.4997
-
Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 95:4997-5002, 1998. (Pubitemid 28208539)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.9
, pp. 4997-5002
-
-
Jurgensmeier, J.M.1
Xie, Z.2
Deveraux, Q.3
Ellerby, L.4
Bredesen, D.5
Reed, J.C.6
-
52
-
-
33744514462
-
Functional estrogen receptors in the mitochondria of breast cancer cells
-
DOI 10.1091/mbc.E05-11-1013
-
Pedram A, Razandi M, Wallace DC, Levin ER. Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell 17: 2125-2137, 2006. (Pubitemid 44011729)
-
(2006)
Molecular Biology of the Cell
, vol.17
, Issue.5
, pp. 2125-2137
-
-
Pedram, A.1
Razandi, M.2
Wallace, D.C.3
Levin, E.R.4
-
53
-
-
20144367155
-
Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane
-
DOI 10.1074/jbc.M410869200
-
Kashkar H, Wiegmann K, Yazdanpanah B, Haubert D, Kronke M. Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane. J Biol Chem 280:20804-20813, 2005. (Pubitemid 40776785)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20804-20813
-
-
Kashkar, H.1
Wiegmann, K.2
Yazdanpanah, B.3
Haubert, D.4
Kronke, M.5
-
54
-
-
0035881568
-
Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K
-
Sun M, Paciga JE, Feldman RI, Yuan Z, Coppola D, Lu YY, Shelley SA, Nicosia SV, Cheng JQ. Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer Res 61:5985-5991, 2001. (Pubitemid 32762525)
-
(2001)
Cancer Research
, vol.61
, Issue.16
, pp. 5985-5991
-
-
Sun, M.1
Paciga, J.E.2
Feldman, R.I.3
Yuan, Z.-Q.4
Coppola, D.5
You Yong, L.6
Shelley, S.A.7
Nicosia, S.V.8
Cheng, J.Q.9
-
55
-
-
1542357331
-
Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc
-
Ostrakhovitch EA, Cherian MG. Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. Arch Biochem Biophys 423:351-361, 2004.
-
(2004)
Arch Biochem Biophys
, vol.423
, pp. 351-361
-
-
Ostrakhovitch, E.A.1
Cherian, M.G.2
-
56
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14:381-395, 2002.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
57
-
-
47949086963
-
Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development
-
Tran MA, Smith CD, Kester M, Robertson GP. Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development. Clin Cancer Res 14:3571-3581, 2008.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3571-3581
-
-
Tran, M.A.1
Smith, C.D.2
Kester, M.3
Robertson, G.P.4
-
58
-
-
34249286598
-
Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells
-
DOI 10.1016/j.canlet.2006.12.035, PII S0304383507000079
-
Zhang M, Fang X, Liu H, Guo R, Wu X, Li B, Zhu F, Ling Y, Griffith BN, Wang S, Yang D. Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells. Cancer Lett 252:244-258, 2007. (Pubitemid 46809794)
-
(2007)
Cancer Letters
, vol.252
, Issue.2
, pp. 244-258
-
-
Zhang, M.1
Fang, X.2
Liu, H.3
Guo, R.4
Wu, X.5
Li, B.6
Zhu, F.7
Ling, Y.8
Griffith, B.N.9
Wang, S.10
Yang, D.11
-
59
-
-
35948936347
-
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin
-
DOI 10.1158/0008-5472.CAN-07-2090
-
Sankala HM, Hait NC, Paugh SW, Shida D, Lepine S, Elmore LW, Dent P, Milstien S, Spiegel S. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res 67:10466-10474, 2007. (Pubitemid 350070822)
-
(2007)
Cancer Research
, vol.67
, Issue.21
, pp. 10466-10474
-
-
Sankala, H.M.1
Hait, N.C.2
Paugh, S.W.3
Shida, D.4
Lepine, S.5
Elmore, L.W.6
Dent, P.7
Milstien, S.8
Spiegel, S.9
-
60
-
-
38349137676
-
Tamoxifen-stimulated growth of breast cancer due to p21 loss
-
Abukhdeir AM, Vitolo MI, Argani P, De Marzo AM, Karakas B, Konishi H, Gustin JP, Lauring J, Garay JP, Pendleton C, Konishi Y, Blair BG, Brenner K, Garrett-Mayer E, Carraway H, Bachman KE, Park BH. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proc Natl Acad Sci U S A 105:288-293, 2008.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 288-293
-
-
Abukhdeir, A.M.1
Vitolo, M.I.2
Argani, P.3
De Marzo, A.M.4
Karakas, B.5
Konishi, H.6
Gustin, J.P.7
Lauring, J.8
Garay, J.P.9
Pendleton, C.10
Konishi, Y.11
Blair, B.G.12
Brenner, K.13
Garrett-Mayer, E.14
Carraway, H.15
Bachman, K.E.16
Park, B.H.17
-
61
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
DOI 10.1038/43474
-
Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in antiapoptotic PDGF signalling. Nature 401:86-90, 1999. (Pubitemid 29418448)
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
62
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires tie Akt serine- Threonine kinase
-
DOI 10.1038/43466
-
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85, 1999. (Pubitemid 29418447)
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
63
-
-
15944379896
-
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation
-
DOI 10.1016/j.molcel.2005.03.006
-
Park KJ, Krishnan V, O'Malley BW, Yamamoto Y, Gaynor RB. Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Mol Cell 18:71-82, 2005. (Pubitemid 40444649)
-
(2005)
Molecular Cell
, vol.18
, Issue.1
, pp. 71-82
-
-
Park, K.-J.1
Krishnan, V.2
O'Malley, B.W.3
Yamamoto, Y.4
Gaynor, R.B.5
-
64
-
-
36248970239
-
Akt-induced tamoxifen resistance is associated with altered FKHR regulation
-
DOI 10.1080/07357900701513538, PII 783100900
-
Silva J, Cavazos DA, Donzis E, Friedrichs WE, Marciniak R, Degraffenried LA. Akt-induced tamoxifen resistance is associated with altered FKHR regulation. Cancer Invest 18 Oct :1-5, 2007 [Epub ahead of print]. (Pubitemid 350135740)
-
(2007)
Cancer Investigation
, vol.25
, Issue.7
, pp. 569-573
-
-
Silva, J.1
Cavazos, D.A.2
Donzis, E.3
Friedrichs, W.E.4
Marciniak, R.5
Degraffenried, L.A.6
-
65
-
-
31544445749
-
2-terminal kinase and Akt
-
DOI 10.1158/0008-5472.CAN-05-1997
-
Sunters A, Madureira PA, Pomeranz KM, Aubert M, Brosens JJ, Cook SJ, Burgering BM, Coombes RC, Lam EW. Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res 66:212-220, 2006. (Pubitemid 43166027)
-
(2006)
Cancer Research
, vol.66
, Issue.1
, pp. 212-220
-
-
Sunters, A.1
Madureira, P.A.2
Pomeranz, K.M.3
Aubert, M.4
Brosens, J.J.5
Cook, S.J.6
Burgering, B.M.T.7
Coombes, R.C.8
Lam, E.W.-F.9
-
66
-
-
22344446415
-
Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
-
DOI 10.1158/1078-0432.CCR-04-2402
-
Boulay A, Rudloff J, Ye J, Zumstein-Mecker S, O'Reilly T, Evans DB, Chen S, Lane HA. Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin Cancer Res 11:5319-5328, 2005. (Pubitemid 41003721)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.14
, pp. 5319-5328
-
-
Boulay, A.1
Rudloff, J.2
Ye, J.3
Zumstein-Mecker, S.4
O'Reilly, T.5
Evans, D.B.6
Chen, S.7
Lane, H.A.8
-
67
-
-
37149020235
-
The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: Results of a phase I study with pharmacokinetics
-
DOI 10.1016/j.ejca.2007.10.003, PII S0959804907007939
-
Awada A, Cardoso F, Fontaine C, Dirix L, De Greve J, Sotiriou C, Steinseifer J, Wouters C, Tanaka C, Zoellner U, Tang P, Piccart M. The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: results of a phase I study with pharmacokinetics. Eur J Cancer 44:84-91, 2008. (Pubitemid 350256937)
-
(2008)
European Journal of Cancer
, vol.44
, Issue.1
, pp. 84-91
-
-
Awada, A.1
Cardoso, F.2
Fontaine, C.3
Dirix, L.4
De Greve, J.5
Sotiriou, C.6
Steinseifer, J.7
Wouters, C.8
Tanaka, C.9
Zoellner, U.10
Tang, P.11
Piccart, M.12
-
68
-
-
0033565728
-
Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells
-
DOI 10.1002/(SICI)1097-0142(19990715)86:2<300::AID-CNCR14>3.0.CO;2- H
-
Lucci A, Han TY, Liu YY, Giuliano AE, Cabot MC. Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells. Cancer 86:300-311, 1999. (Pubitemid 29327587)
-
(1999)
Cancer
, vol.86
, Issue.2
, pp. 300-311
-
-
Lucci, A.1
Han, T.-Y.2
Liu, Y.-Y.3
Giuliano, A.E.4
Cabot, M.C.5
-
69
-
-
0033557521
-
SDZ PSC 833, the cyclosporine a analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells
-
Cabot MC, Giuliano AE, Han TY, Liu YY. SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells. Cancer Res 59:880-885, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 880-885
-
-
Cabot, M.C.1
Giuliano, A.E.2
Han, T.Y.3
Liu, Y.Y.4
-
70
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
DOI 10.1074/jbc.M506182200
-
Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R, Botti J, Codogno P. Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 281:8518-8527, 2006. (Pubitemid 43847954)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.13
, pp. 8518-8527
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Carpentier, S.4
Levade, T.5
Ghidoni, R.6
Botti, J.7
Codogno, P.8
-
71
-
-
0033532912
-
Increase of ceramide and induction of mixed apoptosis/necrosis by N- (4-hydroxyphenyl)-retinamide in neuroblastoma cell lines
-
Maurer BJ, Metelitsa LS, Seeger RC, Cabot MC, Reynolds CP. Increase of ceramide and induction of mixed apoptosis/necrosis by N- (4-hydroxyphenyl)- retinamide in neuroblastoma cell lines. J Natl Cancer Inst 91:1138-1146, 1999.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1138-1146
-
-
Maurer, B.J.1
Metelitsa, L.S.2
Seeger, R.C.3
Cabot, M.C.4
Reynolds, C.P.5
-
72
-
-
0035032521
-
Taxol-induced ceramide generation and apoptosis in human breast cancer cells
-
DOI 10.1007/s002800000265
-
Charles AG, Han TY, Liu YY, Hansen N, Giuliano AE, Cabot MC. Taxol-induced ceramide generation and apoptosis in human breast cancer cells. Cancer Chemother Pharmacol 47:444-450, 2001. (Pubitemid 32397622)
-
(2001)
Cancer Chemotherapy and Pharmacology
, vol.47
, Issue.5
, pp. 444-450
-
-
Charles, A.G.1
Han, T.-Y.2
Liu, Y.Y.3
Hansen, N.4
Giuliano, A.E.5
Cabot, M.C.6
-
73
-
-
0033897314
-
Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line
-
Mehta S, Blackinton D, Omar I, Kouttab N, Myrick D, Klostergaard J, Wanebo H. Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line. Cancer Chemother Pharmacol 46:85-92, 2000. (Pubitemid 30624840)
-
(2000)
Cancer Chemotherapy and Pharmacology
, vol.46
, Issue.2
, pp. 85-92
-
-
Mehta, S.1
Blackinton, D.2
Omar, I.3
Kouttab, N.4
Myrick, D.5
Mehta, S.6
Myrick, D.7
Klostergaard, J.8
Wanebo, H.9
-
74
-
-
1842717386
-
Novel Ceramide Analogs as Potential Chemotherapeutic Agents in Breast Cancer
-
DOI 10.1124/jpet.103.062760
-
Struckhoff AP, Bittman R, Burow ME, Clejan S, Elliott S, Hammond T, Tang Y, Beckman BS. Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. J Pharmacol Exp Ther 309: 523-532, 2004. (Pubitemid 38542603)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.309
, Issue.2
, pp. 523-532
-
-
Struckhoff, A.P.1
Bittman, R.2
Burow, M.E.3
Clejan, S.4
Elliott, S.5
Hammond, T.6
Tang, Y.7
Beckman, B.S.8
-
75
-
-
27944510693
-
Fumonisin B1 induces necrotic cell death in BV-2 cells and murine cultured astrocytes and is antiproliferative in BV-2 cells while N2A cells and primary cortical neurons are resistant
-
Osuchowski MF, Sharma RP. Fumonisin B1 induces necrotic cell death in BV-2 cells and murine cultured astrocytes and is antiproliferative in BV-2 cells while N2A cells and primary cortical neurons are resistant. Neurotoxicology 26:981-992, 2005.
-
(2005)
Neurotoxicology
, vol.26
, pp. 981-992
-
-
Osuchowski, M.F.1
Sharma, R.P.2
-
76
-
-
0036218618
-
Cardiovascular changes associated with intravenous administration of fumonisin B1 in horses
-
Smith GW, Constable PD, Foreman JH, Eppley RM, Waggoner AL, Tumbleson ME, Haschek WM. Cardiovascular changes associated with intravenous administration of fumonisin B1 in horses. Am J Vet Res 63:538-545, 2002.
-
(2002)
Am J Vet Res
, vol.63
, pp. 538-545
-
-
Smith, G.W.1
Constable, P.D.2
Foreman, J.H.3
Eppley, R.M.4
Waggoner, A.L.5
Tumbleson, M.E.6
Haschek, W.M.7
-
77
-
-
33244482534
-
Lethal endotoxic shock using alpha-galactosylceramide sensitization as a new experimental model of septic shock
-
DOI 10.1038/labinvest.3700388, PII 3700388
-
Ito H, Koide N, Hassan F, Islam S, Tumurkhuu G, Mori I, Yoshida T, Kakumu S, Moriwaki H, Yokochi T. Lethal endotoxic shock using alpha-galactosylceramide sensitization as a new experimental model of septic shock. Lab Invest 86:254-261, 2006. (Pubitemid 43276957)
-
(2006)
Laboratory Investigation
, vol.86
, Issue.3
, pp. 254-261
-
-
Ito, H.1
Koide, N.2
Hassan, F.3
Islam, S.4
Tumurkhuu, G.5
Mori, I.6
Yoshida, T.7
Kakumu, S.8
Moriwaki, H.9
Yokochi, T.10
-
78
-
-
18144404605
-
Positively charged ceramide is a potent inducer of mitochondrial permeabilization
-
DOI 10.1074/jbc.M411707200
-
Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM. Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem 280: 16096-16105, 2005. (Pubitemid 40616734)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.16
, pp. 16096-16105
-
-
Novgorodov, S.A.1
Szulc, Z.M.2
Luberto, C.3
Jones, J.A.4
Bielawski, J.5
Bielawska, A.6
Hannun, Y.A.7
Obeid, L.M.8
-
79
-
-
18244404047
-
Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma
-
DOI 10.1158/1078-0432.CCR-04-1770
-
Stover TC, Sharma A, Robertson GP, Kester M. Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma. Clin Cancer Res 11:3465-3474, 2005. (Pubitemid 40627901)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.9
, pp. 3465-3474
-
-
Stover, T.C.1
Sharma, A.2
Robertson, G.P.3
Kester, M.4
-
80
-
-
38549169099
-
Novel analogs of D-e-MAPP and B13. Part 2: Signature effects on bioactive sphingolipids
-
Bielawska A, Bielawski J, Szulc ZM, Mayroo N, Liu X, Bai A, Elojeimy S, Rembiesa B, Pierce J, Norris JS, Hannun YA. Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. Bioorg Med Chem 16:1032-1045, 2008.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 1032-1045
-
-
Bielawska, A.1
Bielawski, J.2
Szulc, Z.M.3
Mayroo, N.4
Liu, X.5
Bai, A.6
Elojeimy, S.7
Rembiesa, B.8
Pierce, J.9
Norris, J.S.10
Hannun, Y.A.11
-
82
-
-
0031899553
-
Glucosylceramide: A marker for multiple-drug resistant cancers
-
Lucci A, Cho WI, Han TY, Giuliano AE, Morton DL, Cabot MC. Glucosylceramide: a marker for multiple-drug resistant cancers. Anticancer Res 18:475-480, 1998. (Pubitemid 28174859)
-
(1998)
Anticancer Research
, vol.18
, Issue.1 B
, pp. 475-480
-
-
Lucci, A.1
Cho, W.I.2
Han, T.-Y.3
Giuliano, A.E.4
Morton, D.L.5
Cabot, M.C.6
-
83
-
-
18144371163
-
Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
-
DOI 10.1158/0008-5472.CAN-04-2329
-
Gouaze V, Liu YY, Prickett CS, Yu JY, Giuliano AE, Cabot MC. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res 65:3861-3867, 2005. (Pubitemid 40616367)
-
(2005)
Cancer Research
, vol.65
, Issue.9
, pp. 3861-3867
-
-
Gouaze, V.1
Liu, Y.-Y.2
Prickett, C.S.3
Yu, J.Y.4
Giuliano, A.E.5
Cabot, M.C.6
-
84
-
-
24044551995
-
PI3K/Akt/mTOR pathway as a target for cancer therapy
-
DOI 10.1097/01.cad.0000173476.67239.3b
-
Morgensztern D, McLeod HL. PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 16:797-803, 2005. (Pubitemid 41215743)
-
(2005)
Anti-Cancer Drugs
, vol.16
, Issue.8
, pp. 797-803
-
-
Morgensztern, D.1
McLeod, H.L.2
-
85
-
-
45749139274
-
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells
-
DOI 10.1248/bpb.31.1177
-
Nagaoka Y, Otsuki K, Fujita T, Uesato S. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biol Pharm Bull 31: 1177-1181, 2008. (Pubitemid 351871174)
-
(2008)
Biological and Pharmaceutical Bulletin
, vol.31
, Issue.6
, pp. 1177-1181
-
-
Nagaoka, Y.1
Otsuki, K.2
Fujita, T.3
Uesato, S.4
-
86
-
-
13244259440
-
Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway
-
DOI 10.1074/jbc.M409066200
-
Becker KP, Kitatani K, Idkowiak-Baldys J, Bielawski J, Hannun YA. Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J Biol Chem 280:2606-2612, 2005. (Pubitemid 40189363)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.4
, pp. 2606-2612
-
-
Becker, K.P.1
Kitatani, K.2
Idkowiak-Baldys, J.3
Bielawski, J.4
Hannun, Y.A.5
-
87
-
-
38349045075
-
Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells
-
Gouaze-Andersson V, Yu JY, Kreitenberg AJ, Bielawska A, Giuliano AE, Cabot MC. Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells. Biochim Biophys Acta 1771:1407-1417, 2007.
-
(2007)
Biochim Biophys Acta
, vol.1771
, pp. 1407-1417
-
-
Gouaze-Andersson, V.1
Yu, J.Y.2
Kreitenberg, A.J.3
Bielawska, A.4
Giuliano, A.E.5
Cabot, M.C.6
|