메뉴 건너뛰기




Volumn 6, Issue , 2006, Pages

Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DOXORUBICIN; ETOPOSIDE; MUTANT PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; THAPSIGARGIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 33748668261     PISSN: 14712407     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-6-213     Document Type: Article
Times cited : (88)

References (51)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 0035895540 scopus 로고    scopus 로고
    • Apoptotoic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons
    • Aravind L, Dixit VM, Koorin EV: Apoptotoic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science 2001, 291:1279-1284.
    • (2001) Science , vol.291 , pp. 1279-1284
    • Aravind, L.1    Dixit, V.M.2    Koorin, E.V.3
  • 6
    • 0029583491 scopus 로고
    • Molecular evolution and secondary structure conservation in the B-cell lymphoma leukemia (bcl-2) family of proto-oncogene products
    • Evans DE, Mansel RE: Molecular evolution and secondary structure conservation in the B-cell lymphoma leukemia (bcl-2) family of proto-oncogene products. J Mol Evol 1995, 41:775-783.
    • (1995) J Mol Evol , vol.41 , pp. 775-783
    • Evans, D.E.1    Mansel, R.E.2
  • 8
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl-2 family: Regulators of the cellular life-or-death switch
    • Cory S, Adams JM: The Bcl-2 family: regulators of the cellular life-or-death switch. Nature Rev Cancer 2:647-656.
    • Nature Rev Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 10
    • 0029077154 scopus 로고
    • Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis
    • Lipponen P, Pietilainen T, Kosma VM, Aaltomaa S, Eskelinen M, Syrjanen KJ: Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis. Pathol 1995, 177:49-55.
    • (1995) Pathol , vol.177 , pp. 49-55
    • Lipponen, P.1    Pietilainen, T.2    Kosma, V.M.3    Aaltomaa, S.4    Eskelinen, M.5    Syrjanen, K.J.6
  • 11
    • 0028917190 scopus 로고
    • Expression of Bcl-2 protein predicts efficacy of adjuvant treatments in operable node positive breast cancers
    • Gasparini BM, Donglioni C, Palma PL: Expression of Bcl-2 protein predicts efficacy of adjuvant treatments in operable node positive breast cancers. Clin Cancer Res 1995, 1:189-198.
    • (1995) Clin Cancer Res , vol.1 , pp. 189-198
    • Gasparini, B.M.1    Donglioni, C.2    Palma, P.L.3
  • 12
    • 0030805125 scopus 로고    scopus 로고
    • Overexpression of Bcl-x protein in primary breast cancer is associated with high grade and nodal metastases
    • Olapadu Ol, Adeyanju MO, Safa AR, Hagos F, Mick R, Thompson CB: Overexpression of Bcl-x protein in primary breast cancer is associated with high grade and nodal metastases. Cancer J Sci Am 1997, 3:230-237.
    • (1997) Cancer J Sci Am , vol.3 , pp. 230-237
    • Olapadu, O.I.1    Adeyanju, M.O.2    Safa, A.R.3    Hagos, F.4    Mick, R.5    Thompson, C.B.6
  • 14
    • 0027362667 scopus 로고
    • Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
    • Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC: Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 1993, 53:4701-4714.
    • (1993) Cancer Res , vol.53 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 15
    • 0028242493 scopus 로고
    • Assembly of Bcl-2 into microsomal and outer mitochondrial membranes
    • Janiak F, Leber B, Andrews DW: Assembly of Bcl-2 into microsomal and outer mitochondrial membranes. J Biol Chem 1994, 269:9842-9849.
    • (1994) J Biol Chem , vol.269 , pp. 9842-9849
    • Janiak, F.1    Leber, B.2    Andrews, D.W.3
  • 16
    • 0028170778 scopus 로고
    • bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria
    • Gonzalez-Garcia M, Perez, Ballestero R, Ding L, Duan L, Boise LH, Thompson CB, Nunez G: bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 1994, 120:3033-3042.
    • (1994) Development , vol.120 , pp. 3033-3042
    • Gonzalez-Garcia, M.1    Perez, B.R.2    Ding, L.3    Duan, L.4    Boise, L.H.5    Thompson, C.B.6    Nunez, G.7
  • 17
    • 0030963602 scopus 로고    scopus 로고
    • Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
    • Hsu YT, Wolter KG, Youle RG: Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci USA 1997, 94:3668-3672.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3668-3672
    • Hsu, Y.T.1    Wolter, K.G.2    Youle, R.G.3
  • 18
    • 0029760303 scopus 로고    scopus 로고
    • Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types
    • Zhu W, Cowie A, Wasfy GW, Penn LZ, Leber B, Andrews DW: Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J 1996, 15:4130-4141.
    • (1996) EMBO J , vol.15 , pp. 4130-4141
    • Zhu, W.1    Cowie, A.2    Wasfy, G.W.3    Penn, L.Z.4    Leber, B.5    Andrews, D.W.6
  • 19
    • 0034604033 scopus 로고    scopus 로고
    • Apoptotic crosstalk between endoplasmic reticulum and mitochondria controlled by bcl-2
    • Hacki J, Egger L, Monney L, Conous S, Rosse T, Fellay I, Borner C: Apoptotic crosstalk between endoplasmic reticulum and mitochondria controlled by bcl-2. Oncogene 2000, 19:2286-2295.
    • (2000) Oncogene , vol.19 , pp. 2286-2295
    • Hacki, J.1    Egger, L.2    Monney, L.3    Conous, S.4    Rosse, T.5    Fellay, I.6    Borner, C.7
  • 21
    • 0037458540 scopus 로고    scopus 로고
    • Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH-3 only proteins
    • Thomenius MJ, Wang NJ, Reineks EZ, Distelhorst CJ: Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH-3 only proteins. J Biol Chem 2003, 278:6243-6250.
    • (2003) J Biol Chem , vol.278 , pp. 6243-6250
    • Thomenius, M.J.1    Wang, N.J.2    Reineks, E.Z.3    Distelhorst, C.J.4
  • 22
    • 1442359853 scopus 로고    scopus 로고
    • There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum
    • Annis MG, Yethon JA, Leber B, Andrews DW: There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum. Biochim Biophys Acta 2004, 1644:115-123.
    • (2004) Biochim Biophys Acta , vol.1644 , pp. 115-123
    • Annis, M.G.1    Yethon, J.A.2    Leber, B.3    Andrews, D.W.4
  • 23
    • 0029157380 scopus 로고
    • Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells
    • Teixeira C, Reed JC, Pratt MA: Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res 1995, 55:3902-3907.
    • (1995) Cancer Res , vol.55 , pp. 3902-3907
    • Teixeira, C.1    Reed, J.C.2    Pratt, M.A.3
  • 24
    • 0040298568 scopus 로고    scopus 로고
    • Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
    • Janicke RU, Sprenprt ML, Wati MR, Porter AG: Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 1998, 273:9357-9360.
    • (1998) J Biol Chem , vol.273 , pp. 9357-9360
    • Janicke, R.U.1    Sprenprt, M.L.2    Wati, M.R.3    Porter, A.G.4
  • 25
    • 0035132464 scopus 로고    scopus 로고
    • Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin and etoposide-induced apoptosis
    • Yang XH, Sladek TL, Liu X, Butler BR, Froelich CJ, Thor AD: Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin and etoposide-induced apoptosis. Cancer Res 2001, 61:348-354.
    • (2001) Cancer Res , vol.61 , pp. 348-354
    • Yang, X.H.1    Sladek, T.L.2    Liu, X.3    Butler, B.R.4    Froelich, C.J.5    Thor, A.D.6
  • 27
    • 0033973291 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Bcl-2 and Bax expression in relation to cell turnover and epithelial differentiation markers in the non-lactating human mammary gland
    • Feuerhake F, Sigg W, Hofter EA, Dimpfl T, Welsch U: Immunohistochemical analysis of Bcl-2 and Bax expression in relation to cell turnover and epithelial differentiation markers in the non-lactating human mammary gland. Cell Tissue Res 299:47-58.
    • Cell Tissue Res , vol.299 , pp. 47-58
    • Feuerhake, F.1    Sigg, W.2    Hofter, E.A.3    Dimpfl, T.4    Welsch, U.5
  • 29
    • 0033542461 scopus 로고    scopus 로고
    • Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts
    • Lee ST, Hoeflich KP, Wasfy GW, Woodgett JR, Lebe B, Andrews DW, Hedley DW, Penn LZ: Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts. Oncogene 1999, 18:3520-8.
    • (1999) Oncogene , vol.18 , pp. 3520-3528
    • Lee, S.T.1    Hoeflich, K.P.2    Wasfy, G.W.3    Woodgett, J.R.4    Lebe, B.5    Andrews, D.W.6    Hedley, D.W.7    Penn, L.Z.8
  • 30
    • 0035848736 scopus 로고    scopus 로고
    • Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event
    • Annis MG, Zamzami N, Zhu W, Penn LZ, Kroemer G, Leber B, Andrews DW: Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event. Oncogene 2001, 20:1939-52.
    • (2001) Oncogene , vol.20 , pp. 1939-1952
    • Annis, M.G.1    Zamzami, N.2    Zhu, W.3    Penn, L.Z.4    Kroemer, G.5    Leber, B.6    Andrews, D.W.7
  • 31
    • 0033214624 scopus 로고    scopus 로고
    • Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7
    • Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, Poirier GG: Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem 1999, 274:28379-84.
    • (1999) J Biol Chem , vol.274 , pp. 28379-28384
    • Germain, M.1    Affar, E.B.2    D'Amours, D.3    Dixit, V.M.4    Salvesen, G.S.5    Poirier, G.G.6
  • 32
    • 0034949086 scopus 로고    scopus 로고
    • Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): Implication of lysosomal proteases
    • Gobeil S, Boucher CC, Nadeau D, Poirier GG: Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases. Cell Death Differ 2001, 8:588-94.
    • (2001) Cell Death Differ , vol.8 , pp. 588-594
    • Gobeil, S.1    Boucher, C.C.2    Nadeau, D.3    Poirier, G.G.4
  • 34
    • 24644432531 scopus 로고    scopus 로고
    • The SERCA pump as a therapeutic target: Making a "smart bomb" for prostate cancer
    • Denmeade SR, Isaacs JT: The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer. Cancer Biol Ther 2005, 4:14-22.
    • (2005) Cancer Biol Ther , vol.4 , pp. 14-22
    • Denmeade, S.R.1    Isaacs, J.T.2
  • 35
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active sphingolipids in cancer pathogenesis and treatment
    • Ogretmen B, Hannan YA: Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004:604-16.
    • (2004) Nat Rev Cancer , pp. 604-616
    • Ogretmen, B.1    Hannan, Y.A.2
  • 36
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • Minotti G, Menna P, Salvatorellai E, Cairo G, Gianni L: Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 2004, 56:185-229.
    • (2004) Pharmacol Rev , vol.56 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorellai, E.3    Cairo, G.4    Gianni, L.5
  • 37
    • 0030032106 scopus 로고    scopus 로고
    • TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    • Hsu H, Shu HB, Pan MG, Goeddel DV: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996, 84:299-308.
    • (1996) Cell , vol.84 , pp. 299-308
    • Hsu, H.1    Shu, H.B.2    Pan, M.G.3    Goeddel, D.V.4
  • 38
    • 0035976902 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
    • Sundararajan R, Cuconati A, Nelson D, White E: Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K. J Biol Chem 2001, 276:45120-7.
    • (2001) J Biol Chem , vol.276 , pp. 45120-45127
    • Sundararajan, R.1    Cuconati, A.2    Nelson, D.3    White, E.4
  • 40
    • 0028290446 scopus 로고
    • Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2
    • Gottschalk AR, Boise LH, Thompson CB, Quintans J: Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc Natl Acad Sci USA 1994, 91:7350-4.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7350-7354
    • Gottschalk, A.R.1    Boise, L.H.2    Thompson, C.B.3    Quintans, J.4
  • 41
    • 0033832629 scopus 로고    scopus 로고
    • Noncaspase proteases in apoptosis
    • Johnson DE: Noncaspase proteases in apoptosis. Leukemia 2000, 14:1695-1703.
    • (2000) Leukemia , vol.14 , pp. 1695-1703
    • Johnson, D.E.1
  • 42
    • 0033049597 scopus 로고    scopus 로고
    • Cleavage of Bcl-2 is an early event inchemotherapy-induced apoptosis of human myeloid leukemia cells
    • Fadeel B, Hassan Z, Hellstrom-Lindberg E, Henter J-I, Orrenius S, Zhitovsky B: Cleavage of Bcl-2 is an early event inchemotherapy-induced apoptosis of human myeloid leukemia cells. Leukemia 1999, 13:719-28.
    • (1999) Leukemia , vol.13 , pp. 719-728
    • Fadeel, B.1    Hassan, Z.2    Hellstrom-Lindberg, E.3    Henter, J.-I.4    Orrenius, S.5    Zhitovsky, B.6
  • 45
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown M, Attardi LD: The role of apoptosis in cancer development and treatment response. Nature Rev Cancer 2005, 5:231-237.
    • (2005) Nature Rev Cancer , vol.5 , pp. 231-237
    • Brown, M.1    Attardi, L.D.2
  • 46
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic Bak is sequestered by Mcl-1 and Bcl-XL, but not by Bcl-2, until displaced by BH3-only proteins
    • Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DCS: Proapoptotic Bak is sequestered by Mcl-1 and Bcl-XL, but not by Bcl-2, until displaced by BH3-only proteins. Genes Dev 2005, 19:1294-1305.
    • (2005) Genes Dev , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3    Wei, A.4    Naik, E.5    Fletcher, J.I.6    Adams, J.M.7    Huang, D.C.S.8
  • 47
    • 2442551481 scopus 로고    scopus 로고
    • During apoptosis Bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria
    • Kim PK, Annis MG, Dlugosz PJ, Leber B, Andrews DW: During apoptosis Bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria. Mol Cell 2004, 14:523-9.
    • (2004) Mol Cell , vol.14 , pp. 523-529
    • Kim, P.K.1    Annis, M.G.2    Dlugosz, P.J.3    Leber, B.4    Andrews, D.W.5
  • 49
    • 0037421190 scopus 로고    scopus 로고
    • Characterization of the signal that directs Bcl-XL, but not Bcl-2, to the mitochondrial outer membrane
    • Kaufman T, Schlipf S, Sanz J, Neubert K, Stein R, Borner C: Characterization of the signal that directs Bcl-XL, but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol 2003, 160:53-64.
    • (2003) J Cell Biol , vol.160 , pp. 53-64
    • Kaufman, T.1    Schlipf, S.2    Sanz, J.3    Neubert, K.4    Stein, R.5    Borner, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.