-
1
-
-
0032537396
-
Tamoxifen for early breast cancer: An overview of the randomised trials
-
Early Breast Cancer Trialists' Collaborative Group
-
Early Breast Cancer Trialists' Collaborative Group (1998) Tamoxifen for early breast cancer: An overview of the randomised trials. Lancet 351:1451-1467.
-
(1998)
Lancet
, vol.351
, pp. 1451-1467
-
-
-
2
-
-
0037434618
-
Selective estrogen-receptor modulators-mechanisms of action and application to clinical practice
-
Riggs BL, Hartmann LC (2003) Selective estrogen-receptor modulators-mechanisms of action and application to clinical practice. N Engl J Med 348:618-629.
-
(2003)
N Engl J Med
, vol.348
, pp. 618-629
-
-
Riggs, B.L.1
Hartmann, L.C.2
-
3
-
-
0037192501
-
Molecular determinants for the tissue specificity of SERMs
-
Shang Y, Brown M (2002) Molecular determinants for the tissue specificity of SERMs. Science 295:2465-2468.
-
(2002)
Science
, vol.295
, pp. 2465-2468
-
-
Shang, Y.1
Brown, M.2
-
4
-
-
0026768801
-
Response after withdrawal of tamoxifen and progestogens in advanced breast cancer
-
Howell A, Dodwell DJ, Anderson H, Redford J (1992) Response after withdrawal of tamoxifen and progestogens in advanced breast cancer. Ann Oncol 3:611-617.
-
(1992)
Ann Oncol
, vol.3
, pp. 611-617
-
-
Howell, A.1
Dodwell, D.J.2
Anderson, H.3
Redford, J.4
-
5
-
-
0018616424
-
Tamoxifen-induced tumor stimulation and withdrawal response
-
Legault-Poisson S, et al. (1979) Tamoxifen-induced tumor stimulation and withdrawal response. Cancer Treat Rep 63:1839-1841.
-
(1979)
Cancer Treat Rep
, vol.63
, pp. 1839-1841
-
-
Legault-Poisson, S.1
-
7
-
-
0020676410
-
Response of metastatic breast cancer to tamoxifen withdrawal: Report of a case
-
Stein W, III, Hortobagyi GN, Blumenschein GR (1983) Response of metastatic breast cancer to tamoxifen withdrawal: Report of a case. J Surg Oncol 22:45-46.
-
(1983)
J Surg Oncol
, vol.22
, pp. 45-46
-
-
Stein III, W.1
Hortobagyi, G.N.2
Blumenschein, G.R.3
-
9
-
-
2942544830
-
Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer
-
Michalides R, et al. (2004) Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell 5:597-605.
-
(2004)
Cancer Cell
, vol.5
, pp. 597-605
-
-
Michalides, R.1
-
10
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
Shou J, et al. (2004) Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 96:926-935.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 926-935
-
-
Shou, J.1
-
11
-
-
0037420192
-
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer
-
Osborne CK, et al. (2003) Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. J Natl Cancer Inst 95:353-361.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 353-361
-
-
Osborne, C.K.1
-
12
-
-
33745714519
-
Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity
-
Rayala SK, Molli PR, Kumar R (2006) Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity. Cancer Res 66:5985-5988.
-
(2006)
Cancer Res
, vol.66
, pp. 5985-5988
-
-
Rayala, S.K.1
Molli, P.R.2
Kumar, R.3
-
13
-
-
0030927929
-
Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution
-
Planas-Silva MD, Weinberg RA (1997) Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution. Mol Cell Biol 17:4059-4069.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4059-4069
-
-
Planas-Silva, M.D.1
Weinberg, R.A.2
-
14
-
-
0034238115
-
Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells
-
Cariou S, et al. (2000) Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Proc Natl Acad Sci USA 97:9042-9046.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9042-9046
-
-
Cariou, S.1
-
15
-
-
13144255998
-
p21(WAF1/CIP1) Mediates the growth response to TGF-beta in human epithelial cells
-
Bachman KE, et al. (2004) p21(WAF1/CIP1) Mediates the growth response to TGF-beta in human epithelial cells. Cancer Biol Ther 3:221-225.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 221-225
-
-
Bachman, K.E.1
-
16
-
-
33746668727
-
Physiologic estrogen receptor alpha signaling in nontumorigenic human mammary epithelial cells
-
Abukhdeir AM, et al. (2006) Physiologic estrogen receptor alpha signaling in nontumorigenic human mammary epithelial cells. Breast Cancer Res Treat 99:23-33.
-
(2006)
Breast Cancer Res Treat
, vol.99
, pp. 23-33
-
-
Abukhdeir, A.M.1
-
17
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314:268-274.
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
-
18
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
el-Deiry WS, et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
el-Deiry, W.S.1
-
19
-
-
0029666272
-
Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 → Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases
-
Balbin M, et al. (1996) Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 → Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases. J Biol Chem 271:15782-15786.
-
(1996)
J Biol Chem
, vol.271
, pp. 15782-15786
-
-
Balbin, M.1
-
20
-
-
13544271667
-
ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line
-
Varshochi R, et al. (2005) ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. J Biol Chem 280:3185-3196.
-
(2005)
J Biol Chem
, vol.280
, pp. 3185-3196
-
-
Varshochi, R.1
-
21
-
-
27944504221
-
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1
-
Duan Z, et al. (2005) Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1. Mol Cell Biol 25:10338-10351.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10338-10351
-
-
Duan, Z.1
-
22
-
-
0037383786
-
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene
-
Lagger G, et al. (2003) The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell Biol 23:2669-2679.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2669-2679
-
-
Lagger, G.1
-
23
-
-
0034730127
-
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
-
Richon VM, Sandhoff TW, Rifkind RA, Marks PA (2000) Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci USA 97:10014-10019.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10014-10019
-
-
Richon, V.M.1
Sandhoff, T.W.2
Rifkind, R.A.3
Marks, P.A.4
-
24
-
-
0036525616
-
5′ CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia
-
Roman-Gomez J, et al. (2002) 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia. Blood 99:2291-2296.
-
(2002)
Blood
, vol.99
, pp. 2291-2296
-
-
Roman-Gomez, J.1
-
25
-
-
30544439189
-
p21WAF1/CIP1 gene is inactivated in metastatic prostatic cancer cell lines by promoter methylation
-
Bott SR, Arya M, Kirby RS, Williamson M (2005) p21WAF1/CIP1 gene is inactivated in metastatic prostatic cancer cell lines by promoter methylation. Prostate Cancer Prostatic Dis 8:321-326.
-
(2005)
Prostate Cancer Prostatic Dis
, vol.8
, pp. 321-326
-
-
Bott, S.R.1
Arya, M.2
Kirby, R.S.3
Williamson, M.4
-
26
-
-
0036969268
-
Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer
-
Yoon DS, et al. (2002) Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer. Am J Pathol 161:391-397.
-
(2002)
Am J Pathol
, vol.161
, pp. 391-397
-
-
Yoon, D.S.1
-
27
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
Bachman KE, et al. (2004) The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 3:772-775.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 772-775
-
-
Bachman, K.E.1
-
28
-
-
33646814055
-
Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese
-
Liang X, et al. (2006) Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese. Cancer Biol Ther 5:544-548.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 544-548
-
-
Liang, X.1
-
29
-
-
0035718191
-
Faslodex (ICI 182, 780), a novel estrogen receptor downregulator-future possibilities in breast cancer
-
Robertson JF (2001) Faslodex (ICI 182, 780), a novel estrogen receptor downregulator-future possibilities in breast cancer. J Steroid Biochem Mol Biol 79:209-212.
-
(2001)
J Steroid Biochem Mol Biol
, vol.79
, pp. 209-212
-
-
Robertson, J.F.1
-
30
-
-
33748421080
-
Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells
-
Karakas B, et al. (2006) Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. Oncogene 25:5561-5569.
-
(2006)
Oncogene
, vol.25
, pp. 5561-5569
-
-
Karakas, B.1
-
31
-
-
0032556952
-
p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells
-
Cayrol C, Knibiehler M, Ducommun B (1998) p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene 16:311-320.
-
(1998)
Oncogene
, vol.16
, pp. 311-320
-
-
Cayrol, C.1
Knibiehler, M.2
Ducommun, B.3
-
32
-
-
0030931670
-
Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex
-
Trowbridge JM, Rogatsky I, Garabedian MJ (1997) Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex. Proc Natl Acad Sci USA 94:10132-10137.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10132-10137
-
-
Trowbridge, J.M.1
Rogatsky, I.2
Garabedian, M.J.3
-
33
-
-
0028329961
-
Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1
-
Lykkesfeldt AE, Madsen MW, Briand P (1994) Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1. Cancer Res 54:1587-1595.
-
(1994)
Cancer Res
, vol.54
, pp. 1587-1595
-
-
Lykkesfeldt, A.E.1
Madsen, M.W.2
Briand, P.3
-
34
-
-
0028144926
-
Characterization of tamoxifen stimulated MCF-7 tumor variants grown in athymic mice
-
Wolf DM, Jordan VC (1994) Characterization of tamoxifen stimulated MCF-7 tumor variants grown in athymic mice. Breast Cancer Res Treat 31:117-127.
-
(1994)
Breast Cancer Res Treat
, vol.31
, pp. 117-127
-
-
Wolf, D.M.1
Jordan, V.C.2
-
35
-
-
0034745353
-
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
Zhou BP, et al. (2001) Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3:245-252.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
-
36
-
-
0032569831
-
Tamoxifen in the treatment of breast cancer
-
Osborne CK (1998) Tamoxifen in the treatment of breast cancer. N Engl J Med 339:1609-1618.
-
(1998)
N Engl J Med
, vol.339
, pp. 1609-1618
-
-
Osborne, C.K.1
-
37
-
-
11244258256
-
Raloxifene rebound regression
-
Dosik M, Kaufman R (2004) Raloxifene rebound regression. Cancer Invest 22:718-722.
-
(2004)
Cancer Invest
, vol.22
, pp. 718-722
-
-
Dosik, M.1
Kaufman, R.2
-
38
-
-
0034884829
-
p21/WAF1/Cip1 expression in invasive ductal breast carcinoma: Relationship to p53, proliferation rate, and survival at 5 years
-
Domagala W, et al. (2001) p21/WAF1/Cip1 expression in invasive ductal breast carcinoma: Relationship to p53, proliferation rate, and survival at 5 years. Virchows Arch 439:132-140.
-
(2001)
Virchows Arch
, vol.439
, pp. 132-140
-
-
Domagala, W.1
-
39
-
-
0346485798
-
Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/neu in breast cancer and is an independent predictor of prognosis
-
Winters ZE, et al. (2003) Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Res 5:R242-R249.
-
(2003)
Breast Cancer Res
, vol.5
-
-
Winters, Z.E.1
-
40
-
-
2542640227
-
Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients
-
Xia W, et al. (2004) Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clin Cancer Res 10:3815-3824.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3815-3824
-
-
Xia, W.1
-
41
-
-
33846268807
-
p27 Phosphorylation by Src regulates inhibition of cyclin E-Cdk2
-
ChuI, et al. (2007) p27 Phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 128:281-294.
-
(2007)
Cell
, vol.128
, pp. 281-294
-
-
ChuI1
-
42
-
-
0024520745
-
-
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
-
Ho SN, et al. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
-
(1989)
Gene
, vol.77
, pp. 51-59
-
-
Ho, S.N.1
|