Preparation, characterization, and in vivo evaluation of insulin-loaded PLA-PEG microspheres for controlled parenteral drug delivery

Drug Development and Industrial Pharmacy

Volumn 35, Issue 11, 2009, Pages 1364-1374

  Sheshala, Ravi ^a   Peh, Kok Khiang ^a   Darwis, Yusrida ^a  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

Author keywords

In vitro release; Insulin; Microspheres; Pharmacokinetic study; Wow double emulsion

Indexed keywords

HUMAN INSULIN; MACROGOL 2000; MICROSPHERE; NEUTRAL INSULIN; POLYLACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; DRUG SCREENING; EMULSION; FEMALE; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; RAT; SCANNING ELECTRON MICROSCOPY; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; LACTATES; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; STREPTOZOCIN; SURFACE PROPERTIES;

EID: 70350325184     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639040902939213     Document Type: Article

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