Nasal delivery of insulin using novel chitosan based formulations: A comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles

Pharmaceutical Research

Volumn 19, Issue 7, 2002, Pages 998-1008

  Dyer, A M ^a   Hinchcliffe, M ^a   Watts, P ^a   Castile, J ^a   Jabbal Gill, I ^a   Nankervis, R ^a   Smith, A ^a   Illum, Lisbeth ^a  

^a Drug Delivery and Clinical Research Centre Ltd   (United Kingdom)

Author keywords

Chitosan; Complex; Insulin; Nanoparticles; Nasal delivery

Indexed keywords

CHITOSAN; INSULIN; NANOPARTICLE; TRIPOLYPHOSPHATE; CHITIN; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG SOLUTION; DRUG SYNTHESIS; FEMALE; GELATION; GLUCOSE BLOOD LEVEL; IONIC STRENGTH; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHEEP; ANIMAL; CHEMISTRY; HUMAN; INTRANASAL DRUG ADMINISTRATION; METHODOLOGY; NANOTECHNOLOGY; POWDER; SOLUTION AND SOLUBILITY; WISTAR RAT;

ADMINISTRATION, INTRANASAL; ANIMAL; CHEMISTRY, PHARMACEUTICAL; CHITIN; COMPARATIVE STUDY; DRUG DELIVERY SYSTEMS; FEMALE; HUMAN; INSULIN; MALE; MODELS, ANIMAL; NANOTECHNOLOGY; PHARMACEUTICAL SOLUTIONS; POWDERS; RATS; RATS, WISTAR; SHEEP; ANIMALS; CHITOSAN; HUMANS;

EID: 0035997333     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016418523014     Document Type: Article

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