Insulin loaded PLGA microspheres: Effect of zinc salts on encapsulation, release, and stability

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 529-542

  Manoharan, Chandrasekar ^a   Singh, Jagdish ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Electrophoresis; Infrared spectroscopy; Microspheres; Poly(lactic glycolic) acid (PLGA or PLA); Protein formulation

Indexed keywords

INCELLIGENT SG; MICROSPHERE; POLYGLACTIN; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG; ZINC ACETATE; ZINC CARBONATE; ZINC OXIDE; ANTIDIABETIC AGENT; CARBONIC ACID DERIVATIVE; DRUG CARRIER; INSULIN; LACTIC ACID; OIL; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; RECOMBINANT PROTEIN; WATER; ZINC DERIVATIVE;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG RELEASE; DRUG STABILITY; MICROENCAPSULATION; PROTEIN SECONDARY STRUCTURE; CHEMISTRY; DRUG FORMULATION; HUMAN; KINETICS; METHODOLOGY; PHARMACEUTICS; PROTEIN DENATURATION; SOLUBILITY;

CARBONATES; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; KINETICS; LACTIC ACID; MICROSPHERES; OILS; POLYGLYCOLIC ACID; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; WATER; ZINC ACETATE; ZINC COMPOUNDS; ZINC OXIDE;

EID: 59849119650     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21445     Document Type: Article

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