A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release

Journal of Controlled Release

Volumn 79, Issue 1-3, 2002, Pages 81-91

  Takenaga, Mitsuko ^a   Yamaguchi, Yoko ^a   Kitagawa, Aki ^a   Ogawa, Yasuaki ^a   Mizushima, Yutaka ^a   Igarashi, Rie ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Co poly(D,L lactic glycolic) acids (PLGA); Controlled release; Diabetes mellitus (DM); Diabetic rat; Insulin

Indexed keywords

ALCOHOL; COPOLYMER; GLYCEROL; INSULIN; OIL; POLYGLYCOLIC ACID; POLYLACTIC ACID; WATER; ZINC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG FORMULATION; HYPOGLYCEMIA; MALE; MICROCAPSULE; MOLECULAR WEIGHT; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SUSTAINED RELEASE PREPARATION;

ANIMALS; BIOCOMPATIBLE MATERIALS; CAPSULES; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; DRUG EVALUATION, PRECLINICAL; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LACTIC ACID; MALE; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR;

EID: 0037133119     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00518-1     Document Type: Article

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