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Volumn 276, Issue 21, 2009, Pages 6074-6083

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - Roles of p53, p73 and HIPK2

Author keywords

Apoptosis; Ataxia telangiectasia mutated (ATM); Ataxia telangiectasia mutated and Rad3 related (ATR); DNA damage; Homeodomain interacting protein kinase 2 (HIPK2); Nuclear bodies; P53; P73; Promyelocytic leukaemia (PML)

Indexed keywords

DOXORUBICIN; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN P53; PROTEIN P73;

EID: 70349957992     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07331.x     Document Type: Short Survey
Times cited : (83)

References (72)
  • 1
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harper JW Elledge SJ (2007) The DNA damage response: ten years after. Mol Cell 28, 739 745.
    • (2007) Mol Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 2
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek J, Bartkova J Lukas J (2007) DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 26, 7773 7779.
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 3
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh Y (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3, 155 168.
    • (2003) Nat Rev Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 4
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan MB Lim DS (2000) The many substrates and functions of ATM. Nat Rev Mol Cell Biol 1, 179 186.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 5
    • 3242882820 scopus 로고    scopus 로고
    • PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways
    • Abraham RT (2004) PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst) 3, 883 887.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 883-887
    • Abraham, R.T.1
  • 6
    • 33745171123 scopus 로고    scopus 로고
    • How cells activate ATR
    • Kumagai A Dunphy WG (2006) How cells activate ATR. Cell Cycle 5, 1265 1268.
    • (2006) Cell Cycle , vol.5 , pp. 1265-1268
    • Kumagai, A.1    Dunphy, W.G.2
  • 10
    • 0037178748 scopus 로고    scopus 로고
    • Interfaces between the detection, signaling, and repair of DNA damage
    • Rouse J Jackson SP (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297, 547 551.
    • (2002) Science , vol.297 , pp. 547-551
    • Rouse, J.1    Jackson, S.P.2
  • 11
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH Lu X (2002) Live or let die: the cell's response to p53. Nat Rev Cancer 2, 594 604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 12
    • 31544457877 scopus 로고    scopus 로고
    • P53 ubiquitination: Mdm2 and beyond
    • Brooks CL Gu W (2006) p53 ubiquitination: Mdm2 and beyond. Mol Cell 21, 307 315.
    • (2006) Mol Cell , vol.21 , pp. 307-315
    • Brooks, C.L.1    Gu, W.2
  • 14
    • 4944255743 scopus 로고    scopus 로고
    • Post-translational modification of p53 in tumorigenesis
    • Bode AM Dong Z (2004) Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 4, 793 805.
    • (2004) Nat Rev Cancer , vol.4 , pp. 793-805
    • Bode, A.M.1    Dong, Z.2
  • 17
    • 0346147033 scopus 로고    scopus 로고
    • Body language: The function of PML nuclear bodies in apoptosis regulation
    • Hofmann TG Will H (2003) Body language: the function of PML nuclear bodies in apoptosis regulation. Cell Death Differ 10, 1290 1299.
    • (2003) Cell Death Differ , vol.10 , pp. 1290-1299
    • Hofmann, T.G.1    Will, H.2
  • 18
    • 36448975490 scopus 로고    scopus 로고
    • Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
    • Bernardi R Pandolfi PP (2007) Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol 8, 1006 1016.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 1006-1016
    • Bernardi, R.1    Pandolfi, P.P.2
  • 19
  • 23
    • 33947273628 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM
    • Dauth I, Kruger J Hofmann TG (2007) Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. Cancer Res 67, 2274 2279.
    • (2007) Cancer Res , vol.67 , pp. 2274-2279
    • Dauth, I.1    Kruger, J.2    Hofmann, T.G.3
  • 24
    • 0345830383 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis
    • Di Stefano V, Rinaldo C, Sacchi A, Soddu S D'Orazi G (2004) Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis. Exp Cell Res 293, 311 320.
    • (2004) Exp Cell Res , vol.293 , pp. 311-320
    • Di Stefano, V.1    Rinaldo, C.2    Sacchi, A.3    Soddu, S.4    D'Orazi, G.5
  • 26
    • 2442678753 scopus 로고    scopus 로고
    • PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains
    • Moller A, Sirma H, Hofmann TG, Rueffer S, Klimczak E, Droge W, Will H Schmitz ML (2003) PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Cancer Res 63, 4310 4314.
    • (2003) Cancer Res , vol.63 , pp. 4310-4314
    • Moller, A.1    Sirma, H.2    Hofmann, T.G.3    Rueffer, S.4    Klimczak, E.5    Droge, W.6    Will, H.7    Schmitz, M.L.8
  • 27
    • 58249110508 scopus 로고    scopus 로고
    • How cells switch HIPK2 on and off
    • Sombroek D Hofmann TG (2009) How cells switch HIPK2 on and off. Cell Death Differ 16, 187 194.
    • (2009) Cell Death Differ , vol.16 , pp. 187-194
    • Sombroek, D.1    Hofmann, T.G.2
  • 28
    • 70349938593 scopus 로고    scopus 로고
    • Reference withdrawn.
    • Reference withdrawn.
  • 30
    • 33847365838 scopus 로고    scopus 로고
    • MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis
    • Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F Soddu S (2007) MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 25, 739 750.
    • (2007) Mol Cell , vol.25 , pp. 739-750
    • Rinaldo, C.1    Prodosmo, A.2    Mancini, F.3    Iacovelli, S.4    Sacchi, A.5    Moretti, F.6    Soddu, S.7
  • 32
    • 41949130508 scopus 로고    scopus 로고
    • Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1
    • Choi DW, Seo YM, Kim EA, Sung KS, Ahn JW, Park SJ, Lee SR Choi CY (2008) Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. J Biol Chem 283, 4682 4689.
    • (2008) J Biol Chem , vol.283 , pp. 4682-4689
    • Choi, D.W.1    Seo, Y.M.2    Kim, E.A.3    Sung, K.S.4    Ahn, J.W.5    Park, S.J.6    Lee, S.R.7    Choi, C.Y.8
  • 33
    • 57349101560 scopus 로고    scopus 로고
    • PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation
    • Shima Y, Shima T, Chiba T, Irimura T, Pandolfi PP Kitabayashi I (2008) PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. Mol Cell Biol 28, 7126 7138.
    • (2008) Mol Cell Biol , vol.28 , pp. 7126-7138
    • Shima, Y.1    Shima, T.2    Chiba, T.3    Irimura, T.4    Pandolfi, P.P.5    Kitabayashi, I.6
  • 34
    • 33847398755 scopus 로고    scopus 로고
    • High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2
    • Pierantoni GM, Rinaldo C, Mottolese M, Di Benedetto A, Esposito F, Soddu S Fusco A (2007) High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J Clin Invest 117, 693 702.
    • (2007) J Clin Invest , vol.117 , pp. 693-702
    • Pierantoni, G.M.1    Rinaldo, C.2    Mottolese, M.3    Di, B.A.4    Esposito, F.5    Soddu, S.6    Fusco, A.7
  • 35
    • 0028070989 scopus 로고
    • P53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles C, Helmberg A Karin M (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370, 220 223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 36
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation-deficient p53
    • Haupt Y, Rowan S, Shaulian E, Vousden KH Oren M (1995) Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 9, 2170 2183.
    • (1995) Genes Dev , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 37
    • 0032561471 scopus 로고    scopus 로고
    • Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system
    • Ding HF, McGill G, Rowan S, Schmaltz C, Shimamura A Fisher DE (1998) Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system. J Biol Chem 273, 28378 28383.
    • (1998) J Biol Chem , vol.273 , pp. 28378-28383
    • Ding, H.F.1    McGill, G.2    Rowan, S.3    Schmaltz, C.4    Shimamura, A.5    Fisher, D.E.6
  • 39
    • 0034717014 scopus 로고    scopus 로고
    • Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
    • Marchenko ND, Zaika A Moll UM (2000) Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 275, 16202 16212.
    • (2000) J Biol Chem , vol.275 , pp. 16202-16212
    • Marchenko, N.D.1    Zaika, A.2    Moll, U.M.3
  • 42
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu JI, Dumont P, Hafey M, Murphy ME George DL (2004) Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 6, 443 450.
    • (2004) Nat Cell Biol , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 44
    • 13544256594 scopus 로고    scopus 로고
    • The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria
    • Nemajerova A, Erster S Moll UM (2005) The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria. Cell Death Differ 12, 197 200.
    • (2005) Cell Death Differ , vol.12 , pp. 197-200
    • Nemajerova, A.1    Erster, S.2    Moll, U.M.3
  • 45
    • 34047103990 scopus 로고    scopus 로고
    • C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
    • Carter S, Bischof O, Dejean A Vousden KH (2007) C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol 9, 428 435.
    • (2007) Nat Cell Biol , vol.9 , pp. 428-435
    • Carter, S.1    Bischof, O.2    Dejean, A.3    Vousden, K.H.4
  • 46
    • 33847276654 scopus 로고    scopus 로고
    • Monoubiquitylation promotes mitochondrial p53 translocation
    • Marchenko ND, Wolff S, Erster S, Becker K Moll UM (2007) Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J 26, 923 934.
    • (2007) EMBO J , vol.26 , pp. 923-934
    • Marchenko, N.D.1    Wolff, S.2    Erster, S.3    Becker, K.4    Moll, U.M.5
  • 47
    • 0348134742 scopus 로고    scopus 로고
    • Mono- versus polyubiquitination: Differential control of p53 fate by Mdm2
    • Li M, Brooks CL, Wu-Baer F, Chen D, Baer R Gu W (2003) Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302, 1972 1975.
    • (2003) Science , vol.302 , pp. 1972-1975
    • Li, M.1    Brooks, C.L.2    Wu-Baer, F.3    Chen, D.4    Baer, R.5    Gu, W.6
  • 48
    • 59149085299 scopus 로고    scopus 로고
    • MSL2 promotes Mdm2-independent cytoplasmic localization of p53
    • Kruse JP Gu W (2009) MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem 284, 3250 3263.
    • (2009) J Biol Chem , vol.284 , pp. 3250-3263
    • Kruse, J.P.1    Gu, W.2
  • 50
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A Kroemer G (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8, 741 752.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 51
    • 33847008972 scopus 로고    scopus 로고
    • DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells
    • Katayama M, Kawaguchi T, Berger MS Pieper RO (2007) DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ 14, 548 558.
    • (2007) Cell Death Differ , vol.14 , pp. 548-558
    • Katayama, M.1    Kawaguchi, T.2    Berger, M.S.3    Pieper, R.O.4
  • 52
    • 1342305505 scopus 로고    scopus 로고
    • P73, the "assistant" guardian of the genome?
    • Melino G (2003) p73, the "assistant" guardian of the genome? Ann N Y Acad Sci 1010, 9 15.
    • (2003) Ann N y Acad Sci , vol.1010 , pp. 9-15
    • Melino, G.1
  • 55
    • 18144371883 scopus 로고    scopus 로고
    • Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo
    • Kim EJ, Park JS Um SJ (2002) Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. J Biol Chem 29, 29.
    • (2002) J Biol Chem , vol.29 , pp. 29
    • Kim, E.J.1    Park, J.S.2    Um, S.J.3
  • 57
    • 14744301343 scopus 로고    scopus 로고
    • JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
    • Yoshida K, Yamaguchi T, Natsume T, Kufe D Miki Y (2005) JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol 7, 278 285.
    • (2005) Nat Cell Biol , vol.7 , pp. 278-285
    • Yoshida, K.1    Yamaguchi, T.2    Natsume, T.3    Kufe, D.4    Miki, Y.5
  • 60
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis
    • Agami R, Blandino G, Oren M Shaul Y (1999) Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 399, 809 813.
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 61
    • 38949123978 scopus 로고    scopus 로고
    • Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
    • Levy D, Adamovich Y, Reuven N Shaul Y (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29, 350 361.
    • (2008) Mol Cell , vol.29 , pp. 350-361
    • Levy, D.1    Adamovich, Y.2    Reuven, N.3    Shaul, Y.4
  • 62
    • 33947382284 scopus 로고    scopus 로고
    • The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
    • Levy D, Adamovich Y, Reuven N Shaul Y (2007) The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. Cell Death Differ 14, 743 751.
    • (2007) Cell Death Differ , vol.14 , pp. 743-751
    • Levy, D.1    Adamovich, Y.2    Reuven, N.3    Shaul, Y.4
  • 65
    • 0142258245 scopus 로고    scopus 로고
    • Homeodomain Interacting Protein Kinase 2 Promotes Apoptosis by Downregulating the Transcriptional Corepressor CtBP
    • Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM Goodman RH (2003) Homeodomain Interacting Protein Kinase 2 Promotes Apoptosis by Downregulating the Transcriptional Corepressor CtBP. Cell 115, 177 186.
    • (2003) Cell , vol.115 , pp. 177-186
    • Zhang, Q.1    Yoshimatsu, Y.2    Hildebrand, J.3    Frisch, S.M.4    Goodman, R.H.5
  • 67
    • 33845942768 scopus 로고    scopus 로고
    • C-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP
    • Wang SY, Iordanov M Zhang Q (2006) c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP. J Biol Chem 281, 34810 34815.
    • (2006) J Biol Chem , vol.281 , pp. 34810-34815
    • Wang, S.Y.1    Iordanov, M.2    Zhang, Q.3
  • 68
    • 0345734277 scopus 로고    scopus 로고
    • HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells
    • Hofmann TG, Stollberg N, Schmitz ML Will H (2003) HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res 63, 8271 8277.
    • (2003) Cancer Res , vol.63 , pp. 8271-8277
    • Hofmann, T.G.1    Stollberg, N.2    Schmitz, M.L.3    Will, H.4
  • 69
    • 23844433285 scopus 로고    scopus 로고
    • Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification
    • Hofmann TG, Jaffray E, Stollberg N, Hay RT Will H (2005) Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. J Biol Chem 280, 29224 29232.
    • (2005) J Biol Chem , vol.280 , pp. 29224-29232
    • Hofmann, T.G.1    Jaffray, E.2    Stollberg, N.3    Hay, R.T.4    Will, H.5
  • 70
    • 0037418238 scopus 로고    scopus 로고
    • JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
    • Lei K Davis RJ (2003) JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A 100, 2432 2437.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2432-2437
    • Lei, K.1    Davis, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.