ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: A key role in glucose-mediated pancreatic β-cell survival

Diabetes

Volumn 55, Issue 8, 2006, Pages 2220-2230

  Costes, Safia ^a   Broca, Christophe ^a   Bertrand, Gyslaine ^a   Lajoix, Anne Dominique ^b   Bataille, Dominique ^b   Bockaert, Joel ^a   Dalle, Stéphane ^a  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b CNRS   (France)

Author keywords

cAMP responsive element binding protein; CREB; DMEM; Dulbecco's modified Eagle's medium; ERK; Extracellular signal regulated kinase; GLP 1; Glucagon like peptide 1; PKA; Protein kinase A; siRNA, small interfering RNA

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN BCL 2; PROTEIN KINASE INHIBITOR; CREBBP PROTEIN, RAT; FLAVONOID; GLUCOSE; ISOQUINOLINE DERIVATIVE; MESSENGER RNA; SMALL INTERFERING RNA; SULFONAMIDE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG ACTIVITY; ELECTRON MICROSCOPY; GLUCOSE HOMEOSTASIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG ANTAGONISM; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; MALE; METABOLISM; PANCREAS ISLET; PHOSPHORYLATION; PHYSIOLOGY; PROTO ONCOGENE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; CREB-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FLAVONOIDS; GENE EXPRESSION; GENES, BCL-2; GLUCOSE; ISLETS OF LANGERHANS; ISOQUINOLINES; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; RNA, MESSENGER; RNA, SMALL INTERFERING; SULFONAMIDES; TRANSFECTION;

EID: 33749344947     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1618     Document Type: Article

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