MEK inhibition exacerbates ischemic calcium imbalance and neuronal cell death in rat cortical cultures

European Journal of Pharmacology

Volumn 553, Issue 1-3, 2006, Pages 18-27

  Franceschini, Davide ^a,b   Giusti, Pietro ^b   Skaper, Stephen D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cortical neurons; Cytoplasmic calcium; Excitotoxicity; Glutamate receptors; Ischemia; MAPK mitogen activated protein kinase ; Swelling

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CYCLIC AMP; DIZOCILPINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ARTICLE; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CELL ENERGY; CELL MEMBRANE POTENTIAL; CELL SWELLING; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; FETUS; GENE EXPRESSION; MITOCHONDRIAL MEMBRANE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; BRAIN ISCHEMIA; CALCIUM; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ELECTRON TRANSPORT; ENERGY METABOLISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GLUCOSE; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIALS; MITOCHONDRIAL MEMBRANES; NEURONS; PHOSPHORYLATION; PREGNANCY; RATS; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 33751251030     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.08.043     Document Type: Article

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