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Volumn 133, Issue 2, 2005, Pages 215-223

3-Nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells

Author keywords

3 Nitropropionic acid; Bcl 2; Huntington's disease; Mitochondrial DNA; Neurotoxicity; PC12 cells

Indexed keywords

3 NITROPROPIONIC ACID; ADENOSINE TRIPHOSPHATE; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

EID: 13844262750     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.10.033     Document Type: Article
Times cited : (72)

References (70)
  • 1
    • 0343983913 scopus 로고
    • 3-Nitropropionate, the toxic substance of indigofera, is a suicide inactivator of succinate dehydrogenase
    • T.A. Alston, L. Mela, and H.F. Bright 3-Nitropropionate, the toxic substance of indigofera, is a suicide inactivator of succinate dehydrogenase Proc. Natl. Acad. Sci. U. S. A. 74 1977 3767 3771
    • (1977) Proc. Natl. Acad. Sci. U. S. A. , vol.74 , pp. 3767-3771
    • Alston, T.A.1    Mela, L.2    Bright, H.F.3
  • 3
    • 0027523461 scopus 로고
    • Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production
    • G. Baffy, T. Miyashita, J.R. Williamson, and J.C. Reed Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production J. Biol. Chem. 268 1993 6511 6519
    • (1993) J. Biol. Chem. , vol.268 , pp. 6511-6519
    • Baffy, G.1    Miyashita, T.2    Williamson, J.R.3    Reed, J.C.4
  • 4
    • 0033040503 scopus 로고    scopus 로고
    • Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells
    • S.W. Ballinger, B. Van Houten, C.A. Coklin, A. Jin, and B. Godley Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells Exp. Eye Res. 68 1999 765 772
    • (1999) Exp. Eye Res. , vol.68 , pp. 765-772
    • Ballinger, S.W.1    Van Houten, B.2    Coklin, C.A.3    Jin, A.4    Godley, B.5
  • 9
    • 0035668684 scopus 로고    scopus 로고
    • Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease
    • M.B. Bogdanov, O.A. Andreassen, A. Dedeoglu, R.J. Ferrante, and M.F. Beal Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease J. Neurochem. 79 6 2001 1246 1249
    • (2001) J. Neurochem. , vol.79 , Issue.6 , pp. 1246-1249
    • Bogdanov, M.B.1    Andreassen, O.A.2    Dedeoglu, A.3    Ferrante, R.J.4    Beal, M.F.5
  • 10
    • 0029614765 scopus 로고
    • Neuronal apoptosis
    • D.E. Bredesen Neuronal apoptosis Ann. Neurol. 38 1995 839 851
    • (1995) Ann. Neurol. , vol.38 , pp. 839-851
    • Bredesen, D.E.1
  • 13
    • 0032496143 scopus 로고    scopus 로고
    • Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss
    • J. Cai, and D.P. Jones Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss J. Biol. Chem. 273 1998 11401 11404
    • (1998) J. Biol. Chem. , vol.273 , pp. 11401-11404
    • Cai, J.1    Jones, D.P.2
  • 14
    • 0029912189 scopus 로고    scopus 로고
    • Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases
    • A.M. Chinnaiyan, K. Orth, K. O'Rourke, H. Duan, G.G. Poirier, and V.M. Dixit Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases J. Biol. Chem. 271 1996 4573 4576
    • (1996) J. Biol. Chem. , vol.271 , pp. 4573-4576
    • Chinnaiyan, A.M.1    Orth, K.2    O'Rourke, K.3    Duan, H.4    Poirier, G.G.5    Dixit, V.M.6
  • 15
    • 0018801043 scopus 로고
    • Inactivation of succinate dehydrogenase by 3-nitropropionate
    • C.J. Coles, D.E. Edmondson, and T.P. Singer Inactivation of succinate dehydrogenase by 3-nitropropionate J. Biol. Chem. 254 1979 5161 5167
    • (1979) J. Biol. Chem. , vol.254 , pp. 5161-5167
    • Coles, C.J.1    Edmondson, D.E.2    Singer, T.P.3
  • 16
    • 0032830749 scopus 로고    scopus 로고
    • Bcl-2 facilitates recovery from DNA damage after oxidative stress
    • G. Deng, J.H. Su, K.J. Ivins, B. Van Houten, and C. Cottman Bcl-2 facilitates recovery from DNA damage after oxidative stress Exp. Neurol. 159 1999 309 318
    • (1999) Exp. Neurol. , vol.159 , pp. 309-318
    • Deng, G.1    Su, J.H.2    Ivins, K.J.3    Van Houten, B.4    Cottman, C.5
  • 18
    • 0031054903 scopus 로고    scopus 로고
    • Energy metabolism during apoptosis. Bcl-2 promotes survival in hematopoietic cells induced to apoptose by growth factor withdrawal by stabilizing a form of metabolic arrest
    • J.M. Garland, and A. Halestrap Energy metabolism during apoptosis. Bcl-2 promotes survival in hematopoietic cells induced to apoptose by growth factor withdrawal by stabilizing a form of metabolic arrest J. Biol. Chem. 272 1997 4680 4688
    • (1997) J. Biol. Chem. , vol.272 , pp. 4680-4688
    • Garland, J.M.1    Halestrap, A.2
  • 19
    • 0028940994 scopus 로고
    • Exacerbation of NMDA, AMPA and l-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate
    • J.G. Greene, and J.T. Greenamyre Exacerbation of NMDA, AMPA and l-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate J. Neurochem. 64 1995 2332 2338
    • (1995) J. Neurochem. , vol.64 , pp. 2332-2338
    • Greene, J.G.1    Greenamyre, J.T.2
  • 20
    • 0027198567 scopus 로고
    • Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum
    • J.G. Greene, R.H. Porter, R.V. Eller, and J.T. Greenamyre Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum J. Neurochem. 61 1993 1151 1154
    • (1993) J. Neurochem. , vol.61 , pp. 1151-1154
    • Greene, J.G.1    Porter, R.H.2    Eller, R.V.3    Greenamyre, J.T.4
  • 22
    • 0004588106 scopus 로고
    • Mycotoxin induced encephalopathy and dystonia in children
    • G.N. Volans J. Sims F.M. Sullivan P. Turner Taylor & Francis London
    • F. He, S. Zhang, C. Zhang, F. Qian, X. Liu, and X. Lo Mycotoxin induced encephalopathy and dystonia in children G.N. Volans J. Sims F.M. Sullivan P. Turner Basic Science in Toxicology 1990 Taylor & Francis London 596 604
    • (1990) Basic Science in Toxicology , pp. 596-604
    • He, F.1    Zhang, S.2    Zhang, C.3    Qian, F.4    Liu, X.5    Lo, X.6
  • 23
    • 0032783532 scopus 로고    scopus 로고
    • Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 3′7′-dihydrofluorescein diacetate, 5 (and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate and dihydrorhodamine 123
    • S.L. Hempel, R. Buettner, Y.Q. O'Malley, D.A. Wessels, and D.M. Flaherty Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 3′7′-dihydrofluorescein diacetate, 5 (and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate and dihydrorhodamine 123 Free Radic. Biol. Med. 27 1999 146 159
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 146-159
    • Hempel, S.L.1    Buettner, R.2    O'Malley, Y.Q.3    Wessels, D.A.4    Flaherty, D.M.5
  • 24
    • 0027513548 scopus 로고
    • Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity
    • T. Hennet, G. Bertoni, C. Richter, and E. Peterhans Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity Cancer Res. 53 1993 1456 1460
    • (1993) Cancer Res. , vol.53 , pp. 1456-1460
    • Hennet, T.1    Bertoni, G.2    Richter, C.3    Peterhans, E.4
  • 26
    • 0022804530 scopus 로고
    • The isolation and structure identification of a toxic substance, 3-nitropropionic acid, produced by arthirinium from mildewed sugar cane
    • W. Hu The isolation and structure identification of a toxic substance, 3-nitropropionic acid, produced by arthirinium from mildewed sugar cane Chin. J. Prev. Med. 20 1986 321 323
    • (1986) Chin. J. Prev. Med. , vol.20 , pp. 321-323
    • Hu, W.1
  • 27
    • 0033593456 scopus 로고    scopus 로고
    • Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid
    • K.J. Ivins, J.K. Ivins, J.P. Sharp, and C.W. Cotman Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid J. Biol. Chem. 274 1999 2107 2112
    • (1999) J. Biol. Chem. , vol.274 , pp. 2107-2112
    • Ivins, K.J.1    Ivins, J.K.2    Sharp, J.P.3    Cotman, C.W.4
  • 28
    • 0028939139 scopus 로고
    • Programmed cell death and Bcl-2 protection in very low oxygen
    • M.D. Jacobson, and M.C. Raff Programmed cell death and Bcl-2 protection in very low oxygen Nature 374 1995 814 816
    • (1995) Nature , vol.374 , pp. 814-816
    • Jacobson, M.D.1    Raff, M.C.2
  • 31
    • 0028878716 scopus 로고
    • Expression of bcl-2 inhibits necrotic neural cell death
    • D.J. Kane, T. Ord, R. Anton, and D.E. Bredesen Expression of bcl-2 inhibits necrotic neural cell death J. Neurosci. Res. 40 2 1995 269 275
    • (1995) J. Neurosci. Res. , vol.40 , Issue.2 , pp. 269-275
    • Kane, D.J.1    Ord, T.2    Anton, R.3    Bredesen, D.E.4
  • 32
  • 33
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • R.M. Kluck, E. Bossy-Wetzel, D.R. Green, and D.D. Newmeyer The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis Science 275 1997 1132 1136
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 34
    • 0027362667 scopus 로고
    • Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
    • S. Krajewski, S. Tanaka, S. Takayama, M.J. Schibler, W. Fenton, and J.C. Reed Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes Cancer Res. 53 1993 4701 4714
    • (1993) Cancer Res. , vol.53 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 35
    • 0026357457 scopus 로고
    • 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin
    • A.C. Ludolph, F. He, P.S. Spencer, J. Hammerstad, and M. Sabri 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin Can. J. Neurol. 18 1991 492 498
    • (1991) Can. J. Neurol. , vol.18 , pp. 492-498
    • Ludolph, A.C.1    He, F.2    Spencer, P.S.3    Hammerstad, J.4    Sabri, M.5
  • 36
    • 0034571235 scopus 로고    scopus 로고
    • DNA damage in brain mitochondria caused by aging and MPTP treatment
    • B.S. Mandavilli, F.A. Syed, and B. Van Houten DNA damage in brain mitochondria caused by aging and MPTP treatment Brain Res. 885 2000 45 52
    • (2000) Brain Res. , vol.885 , pp. 45-52
    • Mandavilli, B.S.1    Syed, F.A.2    Van Houten, B.3
  • 38
    • 0029118747 scopus 로고
    • The mitochondrial inhibitor malonate enhances NMDA toxicity in neonatal rat striatum
    • W.F. Maragos, and F.S. Silverstein The mitochondrial inhibitor malonate enhances NMDA toxicity in neonatal rat striatum Dev. Brain Res. 88 1995 117 121
    • (1995) Dev. Brain Res. , vol.88 , pp. 117-121
    • Maragos, W.F.1    Silverstein, F.S.2
  • 39
    • 0029052829 scopus 로고
    • A selective toxicity toward cultured mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation
    • I. Marey-Semper, M. Gelman, and M. Levi-Strauss A selective toxicity toward cultured mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation J. Neurosci. 15 1995 5912 5918
    • (1995) J. Neurosci. , vol.15 , pp. 5912-5918
    • Marey-Semper, I.1    Gelman, M.2    Levi-Strauss, M.3
  • 42
    • 0034022333 scopus 로고    scopus 로고
    • The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: A hypothesis to explain its specific vulnerability
    • H. Nishino, H. Hida, M. Kumazaki, Y. Shimano, K. Nakajima, H. Shimizu, T. Ooiwa, and H. Baba The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: a hypothesis to explain its specific vulnerability J. Neurotrauma 17 2000 251 260
    • (2000) J. Neurotrauma , vol.17 , pp. 251-260
    • Nishino, H.1    Hida, H.2    Kumazaki, M.3    Shimano, Y.4    Nakajima, K.5    Shimizu, H.6    Ooiwa, T.7    Baba, H.8
  • 43
    • 0030946503 scopus 로고    scopus 로고
    • Mechanism of cell death induced by the mitochondrial toxin 3-nitropropionic acid: Excitotoxic necrosis and delayed apoptosis
    • Z. Pang, and J.W. Geddes Mechanism of cell death induced by the mitochondrial toxin 3-nitropropionic acid: excitotoxic necrosis and delayed apoptosis J. Neurosci. 17 1997 3064 3073
    • (1997) J. Neurosci. , vol.17 , pp. 3064-3073
    • Pang, Z.1    Geddes, J.W.2
  • 44
    • 0033520166 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex
    • M.C. Polidori, P. Mecocci, S.E. Browne, U. Senin, and M.F. Beal Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex Neurosci. Lett. 272 1999 53 56
    • (1999) Neurosci. Lett. , vol.272 , pp. 53-56
    • Polidori, M.C.1    Mecocci, P.2    Browne, S.E.3    Senin, U.4    Beal, M.F.5
  • 45
    • 0031441858 scopus 로고    scopus 로고
    • Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator for hydrogen peroxide in human fibroblasts
    • J.J. Salazar, and B. Van Houten Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator for hydrogen peroxide in human fibroblasts Mutat. Res. 385 1997 139 149
    • (1997) Mutat. Res. , vol.385 , pp. 139-149
    • Salazar, J.J.1    Van Houten, B.2
  • 46
    • 0036355070 scopus 로고    scopus 로고
    • Measurement of oxidative mtDNA damage and repair using quantitative PCR
    • J.H. Santos, B.S. Mandavilli, and B. Van Houten Measurement of oxidative mtDNA damage and repair using quantitative PCR Methods Mol. Biol. 197 2002 159 176
    • (2002) Methods Mol. Biol. , vol.197 , pp. 159-176
    • Santos, J.H.1    Mandavilli, B.S.2    Van Houten, B.3
  • 47
    • 0037449724 scopus 로고    scopus 로고
    • Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death, 2003
    • J.H. Santos, L. Hunakova, Y. Chen, C. Bortner, and B. Van Houten Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death, 2003 J. Biol. Chem. 278 2003 1728 1734
    • (2003) J. Biol. Chem. , vol.278 , pp. 1728-1734
    • Santos, J.H.1    Hunakova, L.2    Chen, Y.3    Bortner, C.4    Van Houten, B.5
  • 49
    • 0032511838 scopus 로고    scopus 로고
    • Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropropionic acid
    • S. Sato, G.T. Gobbel, J. Honkaniemi, Y. Li, T. Kondo, K. Murakami, M. Sato, J.C. Copin, F.R. Sharp, and P.H. Chan Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropropionic acid Brain Res. 808 1998 56 64
    • (1998) Brain Res. , vol.808 , pp. 56-64
    • Sato, S.1    Gobbel, G.T.2    Honkaniemi, J.3    Li, Y.4    Kondo, T.5    Murakami, K.6    Sato, M.7    Copin, J.C.8    Sharp, F.R.9    Chan, P.H.10
  • 50
    • 0032813088 scopus 로고    scopus 로고
    • Repair of DNA damage in mitochondria
    • D.E. Sawyer, and B. Van Houten Repair of DNA damage in mitochondria Mutat. Res. 434 1999 161 176
    • (1999) Mutat. Res. , vol.434 , pp. 161-176
    • Sawyer, D.E.1    Van Houten, B.2
  • 52
    • 0029884711 scopus 로고    scopus 로고
    • Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors
    • S. Shimizu, Y. Eguchi, W. Kamiike, S. Waguri, Y. Uchiyama, H. Matsuda, and Y. Tsujimoto Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors Oncogene 13 1996 21 29
    • (1996) Oncogene , vol.13 , pp. 21-29
    • Shimizu, S.1    Eguchi, Y.2    Kamiike, W.3    Waguri, S.4    Uchiyama, Y.5    Matsuda, H.6    Tsujimoto, Y.7
  • 54
    • 0027289605 scopus 로고
    • Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum
    • J.R. Simpson, and O. Isacson Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum Exp. Neurol. 121 1993 57 64
    • (1993) Exp. Neurol. , vol.121 , pp. 57-64
    • Simpson, J.R.1    Isacson, O.2
  • 55
    • 0028085750 scopus 로고
    • Bcl-2 expression and mitochondrial activity in leukemic cells with different sensitivity to glucocorticoid-induced apoptosis
    • L.A. Smets, J. Van den Berg, D. Acton, B. Top, H. Van Rooij, and M. Verwijs-Janssen Bcl-2 expression and mitochondrial activity in leukemic cells with different sensitivity to glucocorticoid-induced apoptosis Blood 84 1994 1613 1619
    • (1994) Blood , vol.84 , pp. 1613-1619
    • Smets, L.A.1    Van Den Berg, J.2    Acton, D.3    Top, B.4    Van Rooij, H.5    Verwijs-Janssen, M.6
  • 56
    • 0029816144 scopus 로고    scopus 로고
    • Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis
    • A. Srinivasan, L.M. Foster, M.P. Testa, T. Ord, R.W. Keane, D.E. Bredesen, and C. Kayalar Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis J. Neurosci. 16 18 1996 5654 5660
    • (1996) J. Neurosci. , vol.16 , Issue.18 , pp. 5654-5660
    • Srinivasan, A.1    Foster, L.M.2    Testa, M.P.3    Ord, T.4    Keane, R.W.5    Bredesen, D.E.6    Kayalar, C.7
  • 57
    • 0031465737 scopus 로고    scopus 로고
    • 3-Nitropropionic acid induces poly(ADP-ribosyl)ation and apoptosis related gene expression in the striatum in vivo
    • T. Sugino, K. Nozaki, T. Tokime, N. Hashimoto, and H. Kikuchi 3-Nitropropionic acid induces poly(ADP-ribosyl)ation and apoptosis related gene expression in the striatum in vivo Neurosci. Lett. 237 1997 121 124
    • (1997) Neurosci. Lett. , vol.237 , pp. 121-124
    • Sugino, T.1    Nozaki, K.2    Tokime, T.3    Hashimoto, N.4    Kikuchi, H.5
  • 63
    • 0345498292 scopus 로고    scopus 로고
    • Bcl-2 targets the protein kinase Raf-1 to mitochondria
    • H.G. Wang, U.R. Rapp, and J.C. Reed Bcl-2 targets the protein kinase Raf-1 to mitochondria Cell 87 1996 629 638
    • (1996) Cell , vol.87 , pp. 629-638
    • Wang, H.G.1    Rapp, U.R.2    Reed, J.C.3
  • 64
    • 0034996927 scopus 로고    scopus 로고
    • Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitropropionic acid in SK-N-SH human neuroblastoma cells
    • J. Wang, P.S. Green, and J.W. Simpkins Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitropropionic acid in SK-N-SH human neuroblastoma cells J. Neurochem. 77 2001 804 811
    • (2001) J. Neurochem. , vol.77 , pp. 804-811
    • Wang, J.1    Green, P.S.2    Simpkins, J.W.3
  • 65
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • F.M. Yakes, and B. Van Houten Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress Proc. Natl. Acad. Sci. 94 1997 514 519
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 66
    • 0002130423 scopus 로고    scopus 로고
    • PCR-based assays for the detection and quantitation of DNA damage and repair
    • G.P. Pfeifer Plenum Press New York, NY
    • F.M. Yakes, Y. Chen, and B. Van Houten PCR-based assays for the detection and quantitation of DNA damage and repair G.P. Pfeifer Technologies for Detection of DNA Damage and Mutations 1996 Plenum Press New York, NY 171 184
    • (1996) Technologies for Detection of DNA Damage and Mutations , pp. 171-184
    • Yakes, F.M.1    Chen, Y.2    Van Houten, B.3
  • 69
    • 0029550090 scopus 로고
    • Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade
    • G.D. Zeevalk, E. Derr-Yellin, and W.J. Nicklas Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade J. Pharmacol. Exp. Ther. 275 1995 1124 1130
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 1124-1130
    • Zeevalk, G.D.1    Derr-Yellin, E.2    Nicklas, W.J.3
  • 70
    • 0028816071 scopus 로고
    • NMDA receptor involvement in toxicity to dopamine neurons in vitro caused by the succinate dehydrogenase inhibitor 3-nitropropionic acid
    • G.D. Zeevalk, E. Derr-Yellin, and W.J. Nicklas NMDA receptor involvement in toxicity to dopamine neurons in vitro caused by the succinate dehydrogenase inhibitor 3-nitropropionic acid J. Neurochem. 64 1 1995 455 458
    • (1995) J. Neurochem. , vol.64 , Issue.1 , pp. 455-458
    • Zeevalk, G.D.1    Derr-Yellin, E.2    Nicklas, W.J.3


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