Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: An endpoint/toxic response where data from multiple chemicals converge to support a mode of action

Regulatory Toxicology and Pharmacology

Volumn 55, Issue 2, 2009, Pages 205-218

  Cruzan, George ^a   Bus, James ^b   Banton, Marcy ^c   Gingell, Ralph ^d   Carlson, Gary ^e  

^a ToxWorks   (United States)

^b DOW CHEMICAL COMPANY   (United States)

^c Lyondell Basell Industries   (Netherlands)

^d SHELL OIL COMPANY   (United States)

^e PURDUE UNIVERSITY   (United States)

Author keywords

Cumene; CYP2F1; CYP2F2; CYP2F4; Cytotoxicity; Ethylbenzene; Metabolism; Mouse lung tumors; Naphthalene; Styrene

Indexed keywords

ALPHA METHYLSTYRENE; BENZOFURAN DERIVATIVE; COUMARIN; CUMENE; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 2F2; DIVINYLBENZENE; ETHYLBENZENE; NAPHTHALENE; STYRENE; UNCLASSIFIED DRUG;

ARTICLE; CELL COUNT; CELL STRUCTURE; CHEMICAL STRUCTURE; CHROMOSOME ABERRATION; CLARA CELL; CYTOTOXICITY; ENZYME INHIBITION; ENZYME METABOLISM; GENOTOXICITY; HUMAN; LUNG PARENCHYMA; LUNG TUMOR; MICRONUCLEUS; MICROSOME; MOUSE; NONHUMAN; NOSE CAVITY; OXIDATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RAT; SISTER CHROMATID EXCHANGE; SPECIES DIFFERENCE; TOXICOKINETICS;

ADENOCARCINOMA; ADENOMA; ANIMALS; BRONCHIOLES; CARCINOGENS; CELL PROLIFERATION; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; ENDPOINT DETERMINATION; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; INHALATION EXPOSURE; ISOENZYMES; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; MUTAGENICITY TESTS; NAPHTHALENES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; STYRENE;

MUS; RATTUS;

EID: 70349484064     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.07.002     Document Type: Article

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