Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes

Toxicology Letters

Volumn 98, Issue 3, 1998, Pages 131-137

  Carlson, Gary P ^a   Hynes, Dawn E ^b   Mantick, Nancy A ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Liver; Lung; Mouse; Styrene

Indexed keywords

1 [(ALPHA METHYLBENZYL)AMINO]BENZOTRIAZOLE; ALPHA NAPHTHOFLAVONE; CYTOCHROME P450 ISOENZYME; PHENOBARBITAL; STYRENE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HYDROXYLATION; LIVER MICROSOME METABOLISM; LUNG ALVEOLUS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

ANIMALS; BENZOFLAVONES; CHLORAMPHENICOL; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; ENZYME INHIBITORS; LUNG; MICE; MICROSOMES; MICROSOMES, LIVER; OXAZINES; STYRENE; TRIAZOLES;

EID: 0032530624     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00111-8     Document Type: Article

References (18)

1. Bond J.A. Review of the toxicology of styrene. Crit. Rev. Toxicol. 19:1989;227-249.
2. Burke M.D., Thompson S., Elcombe C.R., Halpert J., Haaparanta T., Meyer R.T. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450. Biochem. Pharmacol. 34:1985;3337-3345.
3. Carlson G.P. Comparison of mouse strains for susceptibility to styrene-induced hepatotoxicity and pneumotoxicity. J. Toxicol. Environ. Health. 51:1997;177-187.
4. Carlson G.P. Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice. J. Toxicol. Environ. Health. 51:1997;477-488.
5. Chang A., Buckpitt A., Plopper C., Alworth W. Suicide inhibition of CYP2F2, the enzyme responsible for naphthalene (NA) metabolism to a Clara cell toxicant. Toxicologist. 30:1996;72.
6. Foureman G.L., Harris C., Guengerich F.P., Bend J.R. Stereoselectivity of styrene oxidation in microsomes and in purified cytochrome P-450 enzymes from rat liver. J. Pharmacol. Exp. Ther. 248:1989;492-497.
7. Gadberry M.G., DeNicola D.B., Carlson G.P. Pneumotoxicity and hepatotoxicity of styrene and styrene oxide. J. Toxicol. Environ. Health. 48:1996;273-294.
8. Halpert J., Jaw J-Y., Balfour C., Kaminsky L.S. Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form(s) of rat liver cytochrome P-450. Drug Metab. Dispos. 18:1990;168-174.
9. Litterst C.L., Mimnaugh E.G., Gram T.E. Comparative alterations in extrahepatic drug metabolism by factors known to affect hepatic activity. Biochem. Pharmacol. 26:1977;749-755.
10. Mathews J.M., Bend J.R. N-Alkylaminobenzotriazoles as isozyme-selective suicide inhibitors of rabbit pulmonary microsomal P-450. Mol. Pharmacol. 30:1986;25-32.
11. Miller R.R., Newhook R., Poole A. Styrene production, use and human exposure. Crit. Rev. Toxicol. 24(S1):1994;S1-S10.
12. Morgan D.L., Mahler J.F., Dill J.A., Price H.C., O'Connor R.W., Adkins B. Styrene inhalation toxicity studies in mice. III. Strain differences in susceptibility. Fundam. Appl. Toxicol. 21:1993;326-333.
13. Morgan D.L., Mahler J.F., O'Connor R.W., Price H.C., Adkins B. Styrene inhalation toxicity studies in mice. I. Hepatotoxicity in B6C3F1 mice. Fundam. Appl. Toxicol. 20:1993;325-335.
14. Nakajima T., Elovaara E., Gonzalez F.J., Gelboin H.V., Raunio H., Pelkonen O., Vainio H., Aoyama T. Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chem. Res. Toxicol. 7:1994;891-896.
15. Nakajima T., Wang R.S., Elovaara E., Gonzalez F.J., Gelboin H.V., Vainio H., Aoyama T. CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. Biochem. Pharmacol. 48:1994;637-642.
16. Ono S., Hatanaka T., Hotta H., Satoh T., Gonzalez F.J., Tsutsui M. Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica. 26:1996;681-693.
17. Redinbaugh M.G., Turley R.B. Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions. Anal. Biochem. 153:1986;267-271.
18. Reinke L.A., Moyer M.J. p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab. Dispos. 13:1985;548-552.