Evaluation of genotoxic effects in a group of workers exposed to low levels of styrene

Toxicology

Volumn 171, Issue 2-3, 2002, Pages 175-186

  Laffon, Blanca ^a   Pásaro, Eduardo ^a   Méndez, Josefina ^a  

^a UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

Biomonitoring; Comet assay; Fiberglass reinforced plastics; Micronuclei; Sister chromatid exchanges; Styrene

Indexed keywords

GLASS FIBER; PLASTIC; STYRENE;

ARTICLE; BIOASSAY; BLOOD CELL; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; EVALUATION; GENOTOXICITY; HUMAN; HUMAN CELL; MALE; MICRONUCLEUS; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; URINALYSIS; URINE CULTURE; WORKER;

AGE FACTORS; BLOOD CELLS; COMET ASSAY; DNA DAMAGE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; MALE; MANDELIC ACIDS; MICRONUCLEUS TESTS; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; RISK FACTORS; SISTER CHROMATID EXCHANGE; SMOKING; STYRENE; TIME FACTORS;

EID: 0037186329     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00572-8     Document Type: Article

References (66)

1. Styrene, monomer. Recommended BEI
2. TLVs and BEIs. Threshold limit values for chemical substances and physical agents
3. Factors contributing to discrepancies in population monitoring studies
4. Chromosomal aberrations and alkaline comet assay in families with habitual abortion
5. The genetic toxicology of styrene and styrene oxide
6. Human exposure to styrene. VI. Percutaneous absorption in human volunteers
7. Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects
8. Comparative studies by comet test and SCE analysis in human lymphocytes from 200 healthy subjects
9. Cytogenetic biomonitoring in traffic police workers: Micronucleus test in peripheral blood lymphocytes
10. Analysis of correlated data in human biomonitoring studies. The case of high sister chromatid exchange frequency cells
11. Is human exposure to styrene a cause of cytogenetic damage? A re-analysis of the available evidence
12. Review of the toxicology of styrene
13. Biomarkers in styrene-exposed boatbuilders
14. Genotoxicity in workers exposed to methyl bromide
15. Sister chromatid exchanges in workers exposed to low doses of styrene
16. SCE analysis in human lymphocytes of a Spanish control population
17. The rationale and methodology for quantifying sister chromatid exchange in humans
18. Rejoining of DNA strand breaks induced by propylene oxide and epichlorohydrin in human diploid fibroblasts
19. The micronucleus assay in human lymphocytes: Screening for inter-individual variability and application to biomonitoring
20. Intérêt du test des micronoyaux dans les lymphocytes T binucléés en culture pour la mise en évidence d'un événement génotoxique chez les patients cancéreux
21. The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations
22. The human micronucleus project - An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans
23. A pharmacokinetic model to describe toxicokinetic interactions between 1,3-butadiene and styrene in rats: Predictions for human exposure
24. Styrene toxicity: An ecotoxicological assessment
25. 131I
26. Cytogenetic and hematological effects in plastics workers exposed to styrene
27. Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders
28. Advances in tobacco carcinogenesis
29. Some industrial chemicals
30. Biological monitoring of young workers exposed to polycyclic aromatic hydrocarbons in engine repair workshops
31. Sister-chromatid exchanges in lymphocytes from styrene-exposed boat builders
32. Human effect monitoring in cases of occupational exposure to antineoplastic drugs: A method comparison
33. DNA, mutations and aging
34. Report from the in vitro micronucleus assay working group
35. Chromosomal aberrations in humans induced by urban air pollution: Influence of DNA repair and polymorphisms of glutathione S-transferase M1 and N-acetyltransferase 2
36. Genotoxic effects of styrene-7,8-oxide in human white blood cells: Comet assay in relation to the induction of sister-chromatid exchanges and micronuclei
37. Effects of styrene-7,8-oxide over p53, p21, bcl-2 and bax expression in human lymphocyte cultures
38. Simultaneous high-performance liquid chromatographic determination of urinary mandelic and phenylglyoxylic acids as indirect evaluation of styrene exposure
39. Sister-chromatid exchanges and their distribution in human lymphocytes in relation to age, sex and smoking
40. Chromosomal aberrations and sister-chromatid exchanges in Lithuanian populations: Effects of occupational and environmental exposures
41. Biological monitoring of styrene metabolites in blood
42. Chromosome aberrations, micronuclei and sister-chromatid exchanges in blood lymphocytes after occupational exposure to low levels of styrene
43. Single-strand breaks, chromosome aberrations, sister-chromatid exchanges, and micronuclei in blood lymphocytes of workers exposed to styrene during the production of reinforced plastics
44. Follow-up study of the genetic damage in lymphocytes of pharmacists and nurses handling antineoplastic drugs evaluated by cytokinesis-block micronuclei analysis and single cell gel electrophoresis
45. Styrene production, use and human exposure
46. Genetic toxicity of 1,3-butadiene and styrene
47. Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes
48. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the 'comet' assay
49. Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes
50. DNA damage detected by the comet assay in the white blood cells of workers in a wooden furniture plant
51. Spontaneous micronucleus frequency and age: What are normal values?
52. New Giemsa method for the differential staining of sister chromatids
53. Increased frequency of sister chromatid exchanges in the peripheral lymphocytes of cigarette smokers
54. A re-evaluation of the cytogenetic effects of styrene
55. The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics
56. A simple technique for quantitation of low levels of DNA damage in individual cells
57. Biomonitoring of occupational exposure to styrene in a plastics lamination plant
58. Review of the metabolic fate of styrene
59. Induction of micronuclei by five pyrethroid insecticides in whole-blood isolated human lymphocyte cultures
60. Influence of GST genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes
61. Biomarkers of styrene exposure in lamination workers: Levels of O6-guanine DNA adducts, DNA strand breaks and mutant frequencies in the hypoxanthine guanine phosphoribosyltransferase gene in T-lymphocytes
62. Exposure dependent increase in DNA single strand breaks in leucocytes from workers exposed to low concentrations of styrene
63. Exposure to styrene, uptake, distribution, metabolism and elimination in man
64. Sister-chromatid exchanges in lymphocytes are increased in relation to longitudinally measured occupational exposure to low concentrations of styrene
65. Lymphocyte DNA damage in cigarette factory workers measured by the Comet assay