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Volumn 46, Issue 2, 1998, Pages 266-281

Chronic toxicity/oncogenicity study of styrene in CD rats by inhalation exposure for 104 weeks

Author keywords

CRL CD (Sprague Dawley) rats; Decreased mammary tumors; Decreased pituitary tumors; Inhalation; Nasal irritation; Olfactory epithelium; Oncogenicity; Styrene

Indexed keywords

STYRENE; STYRENE OXIDE;

EID: 0032416947     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2533     Document Type: Article
Times cited : (105)

References (43)
  • 1
    • 0021272976 scopus 로고
    • Inhalation pharmacokinetics: Evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood: Inhaled air ratios
    • M.E. Andersen M.L. Gargas J.C. Ramsey Inhalation pharmacokinetics: Evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood: Inhaled air ratios Toxicol. Appl. Pharmacol. 73 1984 176 187
    • (1984) Toxicol. Appl. Pharmacol. , vol.73 , pp. 176-187
    • Andersen, M.E.1    Gargas, M.L.2    Ramsey, J.C.3
  • 2
    • 0000223087 scopus 로고
    • Properties of sufficiency and statistical tests
    • M.S. Bartlett Properties of sufficiency and statistical tests Proc. R. Soc. Ser. A 160 1937 268 282
    • (1937) Proc. R. Soc. Ser. A , vol.160 , pp. 268-282
    • Bartlett, M.S.1
  • 3
    • 77957176015 scopus 로고
    • Chronic toxicity and three-generation reproduction study of styrene monomer in the drinking water of rats
    • R.P. Beliles J.H. Butala C.R. Stock S. Makris Chronic toxicity and three-generation reproduction study of styrene monomer in the drinking water of rats Fundam. Appl. Toxicol. 5 1985 855 868
    • (1985) Fundam. Appl. Toxicol. , vol.5 , pp. 855-868
    • Beliles, R.P.1    Butala, J.H.2    Stock, C.R.3    Makris, S.4
  • 5
    • 0027967501 scopus 로고
    • Epidemiological studies of styrene-exposed populations
    • D. Coggon Epidemiological studies of styrene-exposed populations Crit. Rev. Toxicol. 24 1994 S107 S116
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. S107-S116
    • Coggon, D.1
  • 6
    • 0023788588 scopus 로고
    • Long-term carcinogenicity bioassays on styrene administered by inhalation, ingestion and injection and styrene oxide administered by ingestion in Sprague–Dawley rats and para-methyl-styrene administered by ingestion in Sprague–Dawley rats and Swiss mice
    • B. Conti C. Maltoni G. Perino A. Gilberti Long-term carcinogenicity bioassays on styrene administered by inhalation, ingestion and injection and styrene oxide administered by ingestion in Sprague–Dawley rats and para-methyl-styrene administered by ingestion in Sprague–Dawley rats and Swiss mice Ann. N.Y. Acad. Sci. 534 1988 203 234
    • (1988) Ann. N.Y. Acad. Sci. , vol.534 , pp. 203-234
    • Conti, B.1    Maltoni, C.2    Perino, G.3    Gilberti, A.4
  • 8
    • 0028214833 scopus 로고
    • A physiologic pharmacokinetic model for styrene and styrene-7,8-oxide in mouse, rat and man
    • Gy.A. Csanády A.L. Mendrala R.J. Nolan J.G. Filser A physiologic pharmacokinetic model for styrene and styrene-7,8-oxide in mouse, rat and man Arch. Toxicol. 68 1994 143 157
    • (1994) Arch. Toxicol. , vol.68 , pp. 143-157
    • Csanády, Gy.A.1    Mendrala, A.L.2    Nolan, R.J.3    Filser, J.G.4
  • 9
    • 85119814578 scopus 로고    scopus 로고
    • EC Council, 1986, Good Laboratory Practices: EC Council Directive 87/18 EEC of 18 December 1986
  • 10
    • 85119790735 scopus 로고
    • R.A. Fisher Statistical Methods for Research Workers 1973 Hafner Publishing Co New York p. 96–97
    • (1973)
    • Fisher, R.A.1
  • 11
    • 85119799966 scopus 로고
    • Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans; Annex: R. Peto et al., Guidelines for Simple Sensitive Significance Tests for Carcinogenic Effects in Long-Term Animal Experiments 1980 p. 311–426
    • (1980)
  • 12
    • 85119786787 scopus 로고    scopus 로고
    • Japan MITI, 1984, Good Laboratory Practices: Japan Ministry of International Trade and Industry, Directive 31 March 1984
  • 13
    • 85119813724 scopus 로고    scopus 로고
    • Jersey, G. C. Balmer, M. F. Quast, J. F. Park, C. N. Scheutz, D. J. Beyer, J. E. Olson, K. J. McCollister, S. B. Rampy, L. W. 1978, Two-Year Chronic Inhalation Toxicity and Carcinogenicity Study on Monomeric Styrene in Rats—Final Report, The Dow Chemical Company, Midland, MI
  • 14
    • 0025642741 scopus 로고
    • Direct determination of styrene-7,8-oxide in blood by gas chromatography with flame ionization detection
    • W. Kessler X. Jiang J.G. Filser Direct determination of styrene-7,8-oxide in blood by gas chromatography with flame ionization detection J. Chromatogr. 534 1990 67 75
    • (1990) J. Chromatogr. , vol.534 , pp. 67-75
    • Kessler, W.1    Jiang, X.2    Filser, J.G.3
  • 15
    • 84943709252 scopus 로고
    • Use of ranks on one-criterion variance analysis
    • W.H. Kruskal W.A. Wallis Use of ranks on one-criterion variance analysis J. Am. Stat. Assoc. 47 1952 583 621
    • (1952) J. Am. Stat. Assoc. , vol.47 , pp. 583-621
    • Kruskal, W.H.1    Wallis, W.A.2
  • 17
    • 85119805496 scopus 로고    scopus 로고
    • Maltoni, C. 1978, Letter to International Cooperative Study Group on Long Term Effects of Styrene, 2 October 1978
  • 18
    • 9844227496 scopus 로고
    • Chi-square test with one degree of freedom: Extensions of the Mantel-Haenszel procedure
    • N. Mantel Chi-square test with one degree of freedom: Extensions of the Mantel-Haenszel procedure J. Am. Stat. Assoc. 58 1966 690 700
    • (1966) J. Am. Stat. Assoc. , vol.58 , pp. 690-700
    • Mantel, N.1
  • 19
    • 0028072971 scopus 로고
    • Review of styrene and styrene oxide long-term animal studies
    • E.E. McConnell J.A. Swenberg Review of styrene and styrene oxide long-term animal studies Crit. Rev. Toxicol. 24 1994 S49 S56
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. S49-S56
    • McConnell, E.E.1    Swenberg, J.A.2
  • 20
    • 85119807567 scopus 로고
    • McConnell Guides for Toxicologic Pathology. 1992 STP/ARP/AFIP Washington
    • (1992)
    • McConnell1
  • 23
    • 85119803574 scopus 로고    scopus 로고
    • National Cancer Institute, 1979a, Bioassay of a Solution of b-Nitrostyrene and Styrene for Possible Carcinogenicity
  • 24
    • 85119803448 scopus 로고    scopus 로고
    • National Cancer Institute, 1979b, Bioassay of Styrene for Possible Carcinogenicity
  • 25
    • 0021792108 scopus 로고
    • Influence of vapours on the nasal mucosa among industry workers
    • L.M. Odkvist C. Edling H. Hellquist Influence of vapours on the nasal mucosa among industry workers Rhinology 23 1985 121 127
    • (1985) Rhinology , vol.23 , pp. 121-127
    • Odkvist, L.M.1    Edling, C.2    Hellquist, H.3
  • 26
    • 85119816020 scopus 로고    scopus 로고
    • OECD, 1982, Good Laboratory Practices in the Testing of Chemicals
  • 27
    • 0022993336 scopus 로고
    • Degeneration and regeneration of respiratory mucosa of rats after exposure to styrene
    • Y. Ohashi H. Ikeoka H. Koshimo J. Nakata Y. Esaki Degeneration and regeneration of respiratory mucosa of rats after exposure to styrene J. Appl. Toxicol. 6 1986 405 412
    • (1986) J. Appl. Toxicol. , vol.6 , pp. 405-412
    • Ohashi, Y.1    Ikeoka, H.2    Koshimo, H.3    Nakata, J.4    Esaki, Y.5
  • 28
    • 0027984001 scopus 로고
    • Evidence for DNA and protein binding by styrene and styrene oxide
    • D.H. Phillips P.B. Farmer Evidence for DNA and protein binding by styrene and styrene oxide Crit. Rev. Toxicol. 24 1994 S35 S46
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. S35-S46
    • Phillips, D.H.1    Farmer, P.B.2
  • 29
    • 0018237850 scopus 로고
    • Effects of long-term oral administration of styrene to mice and rats
    • B. Ponomarkov L. Tomatis Effects of long-term oral administration of styrene to mice and rats Scan. J. Work Environ. Health 4 1978 127 135
    • (1978) Scan. J. Work Environ. Health , vol.4 , pp. 127-135
    • Ponomarkov, B.1    Tomatis, L.2
  • 30
    • 0027937764 scopus 로고
    • The neuroepidemiology of styrene: A critical review of representative literature
    • C.S. Rebert T.A. Hall The neuroepidemiology of styrene: A critical review of representative literature Crit. Rev. Toxicol. 24 1994 S57 S106
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. S57-S106
    • Rebert, C.S.1    Hall, T.A.2
  • 32
    • 0027938910 scopus 로고
    • A critical review of the cytogenetic effects of styrene with an emphasis on human population monitoring: A synopsis
    • D. Scott R.J. Preston A critical review of the cytogenetic effects of styrene with an emphasis on human population monitoring: A synopsis Crit. Rev. Toxicol. 24 1994 S47 S48
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. S47-S48
    • Scott, D.1    Preston, R.J.2
  • 33
    • 77957186914 scopus 로고
    • The effect of body weight on tumor incidence and carcinogenicity testing in B6C3F1 mice and F344 rats
    • S.K. Seilkop The effect of body weight on tumor incidence and carcinogenicity testing in B6C3F1 mice and F344 rats Fundam. Appl. Toxicol. 24 1995 247 259
    • (1995) Fundam. Appl. Toxicol. , vol.24 , pp. 247-259
    • Seilkop, S.K.1
  • 34
    • 0020460705 scopus 로고
    • Hepatic effects of orally administered styrene in rats
    • S.P. Srivastava M. Das M. Mushtaq Hepatic effects of orally administered styrene in rats J. Appl. Toxicol. 2 1982 219 222
    • (1982) J. Appl. Toxicol. , vol.2 , pp. 219-222
    • Srivastava, S.P.1    Das, M.2    Mushtaq, M.3
  • 35
    • 0028027503 scopus 로고
    • Review of the metabolic fate of styrene
    • S.J. Sumner T.R. Fennell Review of the metabolic fate of styrene Crit. Rev. Toxicol. 24 1994 S11 S34
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. S11-S34
    • Sumner, S.J.1    Fennell, T.R.2
  • 36
    • 85119816499 scopus 로고    scopus 로고
    • UK HSE, 1989, Good Laboratory Practice, The United Kingdom Compliance Program, Department of Health and Social Security (1986), 1989
  • 37
    • 85119794516 scopus 로고    scopus 로고
    • US EPA, 1989, Good Laboratory Practice: Toxic Substances Control Act Regulations, Title 40 CFR 792, Federal Register 29 November 1983. Amended Federal Register 17 August 1989
  • 38
    • 0018761943 scopus 로고
    • Adaptive changes caused by intermittent styrene inhalation on xenobiotic transformation
    • H. Vainio J. Jarvisalo E. Taskinen Adaptive changes caused by intermittent styrene inhalation on xenobiotic transformation Toxicol. Appl. Pharmacol. 49 1979 7 14
    • (1979) Toxicol. Appl. Pharmacol. , vol.49 , pp. 7-14
    • Vainio, H.1    Jarvisalo, J.2    Taskinen, E.3
  • 39
    • 85119798904 scopus 로고
    • Nonneoplastic and neoplastic lesions of the mammary gland
    • M.J. van Zwieten J.A. HogenEsch J.A. Majka G.A. Boorman Nonneoplastic and neoplastic lesions of the mammary gland Pathobiology of the Aging Rat 1994 ILSI Press Washington p. 459–475
    • (1994)
    • van Zwieten, M.J.1    HogenEsch, J.A.2    Majka, J.A.3    Boorman, G.A.4
  • 40
    • 0015025451 scopus 로고
    • A test for differences between treatment means when several dose levels are compared with a zero dose control
    • D.A. Williams A test for differences between treatment means when several dose levels are compared with a zero dose control Biometrics 27 1971 103 117
    • (1971) Biometrics , vol.27 , pp. 103-117
    • Williams, D.A.1
  • 41
    • 0015357959 scopus 로고
    • The comparison of several dose levels with a zero dose control
    • D.A. Williams The comparison of several dose levels with a zero dose control Biometrics 28 1972 519 531
    • (1972) Biometrics , vol.28 , pp. 519-531
    • Williams, D.A.1
  • 42
    • 0018574247 scopus 로고
    • The distribution and pharmacokinetics of styrene monomer in rats by the pulmonary route
    • J.R. Withey P.G. Collins The distribution and pharmacokinetics of styrene monomer in rats by the pulmonary route J. Environ. Pathol. Toxicol. 2 1979 1329 1342
    • (1979) J. Environ. Pathol. Toxicol. , vol.2 , pp. 1329-1342
    • Withey, J.R.1    Collins, P.G.2
  • 43
    • 77957177877 scopus 로고
    • Histologic examination of the rat nasal cavity
    • J.T. Young Histologic examination of the rat nasal cavity Fundam. Appl. Toxicol. 1 1981 309 312
    • (1981) Fundam. Appl. Toxicol. , vol.1 , pp. 309-312
    • Young, J.T.1


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