Mechanism of ethylbenzene-induced mouse-specific lung tumor: Metabolism of ethylbenzene by rat, mouse, and human liver and lung microsomes

Toxicological Sciences

Volumn 107, Issue 2, 2009, Pages 352-366

  Saghir, Shakil A ^a   Rick, David L ^a   McClymont, E L ^a   Zhang, Fagen ^a   Bartels, Michael J ^a   Bus, James S ^a  

^a DOW CHEMICAL COMPANY   (United States)

Author keywords

1 phenylethanol; 2 ethylphenol; 4 ethylphenol; Acetophenone; Ethylbenzene; Ethylhydroquinone and ethylcatechol; Ethylquinone; Liver and lung microsomes; Mouse and human microsomal metabolism; Rat

Indexed keywords

2,5 DIHYDROXYETHYLBENZENE GLUTATHIONE; 2,5 ETHYLQUINONE; 3,4 DIHYDROXYETHYLBENZENE GLUTATHIONE; 3,4 ETHYLQUINONE; 4 ETHYLPHENOL; ACETOPHENONE; ETHYLBENZENE; GLUTATHIONE; ORTHO CRESOL; PHENETHYL ALCOHOL; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LIVER MICROSOME; LUNG PARENCHYMA; LUNG TOXICITY; LUNG TUMOR; METABOLISM; METABOLITE; MOUSE; NONHUMAN; OCCUPATIONAL EXPOSURE; OXIDATION; RAT; TISSUE DISTRIBUTION;

ANIMALS; BENZENE DERIVATIVES; BIOTRANSFORMATION; CARCINOGENS; CHILD, PRESCHOOL; GLUTATHIONE; HUMANS; LUNG; LUNG NEOPLASMS; MICE; MICROSOMES; MICROSOMES, LIVER; QUINONES; RATS; VOLATILIZATION;

RATTUS;

EID: 59149099723     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn244     Document Type: Article

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