Procaspase-3 activation as an anti-cancer strategy: Structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3

Journal of Medicinal Chemistry

Volumn 52, Issue 18, 2009, Pages 5721-5731

  Peterson, Quinn P ^a   Hsu, Danny C ^a   Goode, David R ^a   Novotny, Chris J ^a   Totten, Ryan K ^a   Hergenrother, Paul J ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 3; DNA; FLUORESCENT DYE; HYDRAZIDE DERIVATIVE; PROCASPASE 3; PROCASPASE ACTIVATING COMPOUND 1; RABBIT ANTISERUM; UNCLASSIFIED DRUG; ZINC ION;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL STRAIN U937; CELLULAR DISTRIBUTION; CHELATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MELANOMA CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; CHELATING AGENTS; DRUG DESIGN; ENZYME ACTIVATION; FLUORESCENT DYES; HUMANS; HYDRAZONES; INTRACELLULAR SPACE; PIPERAZINES; PROTEIN TRANSPORT; STAINING AND LABELING; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 70349433777     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900722z     Document Type: Article

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