Rapid communication: Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): Correlation with DNA fragmentation

Experimental Cell Research

Volumn 259, Issue 1, 2000, Pages 308-313

  Bedner, Elzbieta ^a,b   Smolewski, Piotr ^a   Amstad, Paul ^c   Darzynkiewicz, Zbigniew ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b POMERANIAN MEDICAL UNIVERSITY   (Poland)

^c Intergen Discovery Products   (United States)

Author keywords

Camptothecin; DNA strand breaks; Laser scanning cytometry; TUNEL

Indexed keywords

CAMPTOTHECIN; CASPASE; CASPASE 6; CASPASE INHIBITOR; CELL DNA; CYCLOHEXIMIDE; DNA FRAGMENT; DNA TOPOISOMERASE; FLUOROCHROME; FLUOROCHROME VALYLALANYLASPARTYL FLUOROMETHYL KETONE; FLUOROCHROME VALYLGLUTAMYLISOLEUCYLASPARTYL FLUOROMETHYL KETONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CYSTEINE PROTEINASE INHIBITOR; ENZYME INHIBITOR; FLUORESCENT DYE; PEPTIDE CHLOROMETHYL KETONE; PROTEIN SYNTHESIS INHIBITOR;

ANALYTIC METHOD; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL STRUCTURE; CHEMICAL LABELING; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME BINDING; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHYSIOLOGY;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CAMPTOTHECIN; CASPASES; CYCLOHEXIMIDE; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; ENZYME INHIBITORS; FLUORESCENT DYES; HL-60 CELLS; HUMANS; IN SITU NICK-END LABELING; PROTEIN SYNTHESIS INHIBITORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034714009     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4955     Document Type: Article

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