메뉴 건너뛰기




Volumn 122, Issue 13, 2009, Pages 2311-2321

Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells

Author keywords

Cell proliferation; Embryonic stem cells; PI3 kinase; Pluripotency; Signal transduction

Indexed keywords

INSULIN; LEUKEMIA INHIBITORY FACTOR; P110 ALPHA; P110 BETA; P110 DELTA; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

EID: 69449087260     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.046557     Document Type: Article
Times cited : (28)

References (66)
  • 2
    • 33744758028 scopus 로고    scopus 로고
    • The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis
    • Armstrong, L., Hughes, O., Yung, S., Hyslop, L., Stewart, R., Wappler, I., Peters, H., Walter, T., Stojkovic, P., Evans, J. et al. (2006). The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Hum. Mol. Gen. 15, 1894-1913.
    • (2006) Hum. Mol. Gen , vol.15 , pp. 1894-1913
    • Armstrong, L.1    Hughes, O.2    Yung, S.3    Hyslop, L.4    Stewart, R.5    Wappler, I.6    Peters, H.7    Walter, T.8    Stojkovic, P.9    Evans, J.10
  • 3
    • 0033574429 scopus 로고    scopus 로고
    • Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
    • Bi, L., Okabe, I., Bernard, D. J., Wynshaw-Boris, A. and Nussbaum, R. L. (1999). Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J. Biol. Chem. 274, 10963-10968.
    • (1999) J. Biol. Chem , vol.274 , pp. 10963-10968
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Wynshaw-Boris, A.4    Nussbaum, R.L.5
  • 4
    • 0036185944 scopus 로고    scopus 로고
    • Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
    • Bi, L., Okabe, I., Bernard, D. J. and Nussbaum, R. L. (2002). Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm. Genome 13, 169-172.
    • (2002) Mamm. Genome , vol.13 , pp. 169-172
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Nussbaum, R.L.4
  • 5
    • 0030875352 scopus 로고    scopus 로고
    • Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells
    • Boeuf, H., Hauss, C., DeGraeve, F., Baran, N. and Kedinger, C. (1997). Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J. Cell Biol. 138, 1207-1217.
    • (1997) J. Cell Biol , vol.138 , pp. 1207-1217
    • Boeuf, H.1    Hauss, C.2    DeGraeve, F.3    Baran, N.4    Kedinger, C.5
  • 6
    • 27644483064 scopus 로고    scopus 로고
    • Regulatory networks in embryo-derived pluripotent stem cells
    • Boiani, M. and Schoeler, H. R. (2005). Regulatory networks in embryo-derived pluripotent stem cells. Nat. Rev. Mol. Cell. Biol. 6, 872-881.
    • (2005) Nat. Rev. Mol. Cell. Biol , vol.6 , pp. 872-881
    • Boiani, M.1    Schoeler, H.R.2
  • 7
    • 58549109668 scopus 로고    scopus 로고
    • Involvement of glycogen synthase kinase-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides
    • Bone, H. K., Damiano, T., Bartlett, S., Perry, A., Letchford, J., Sanchez Ripoll, Y., Nelson, A. S. and Welham, M. J. (2008). Involvement of glycogen synthase kinase-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides. Chem. Biol. 16, 15-27.
    • (2008) Chem. Biol , vol.16 , pp. 15-27
    • Bone, H.K.1    Damiano, T.2    Bartlett, S.3    Perry, A.4    Letchford, J.5    Sanchez Ripoll, Y.6    Nelson, A.S.7    Welham, M.J.8
  • 8
    • 0000854861 scopus 로고
    • Growth of a rat neuroblastoma cell line in serum-free supplemented medium
    • Bottenstein, J. E. and Sato, G. H. (1979). Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. USA 76, 514-517.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 514-517
    • Bottenstein, J.E.1    Sato, G.H.2
  • 9
    • 0024340539 scopus 로고
    • Survival and growth of hippocampal neurons in defined medium at low density: Advantages of a sandwich culture technique or low oxygen
    • Brewer, G. J. and Cotman, C. W. (1989). Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res. 494, 65-74.
    • (1989) Brain Res , vol.494 , pp. 65-74
    • Brewer, G.J.1    Cotman, C.W.2
  • 10
    • 0027226219 scopus 로고
    • Optimized survival of hippocampal neurons in B27-Supplemented neurobasal, a new serum-free medium combination
    • Brewer, G. J., Torricelli, J. R., Evege, E. K. and Prive, P. J. (1993). Optimized survival of hippocampal neurons in B27-Supplemented neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576.
    • (1993) J. Neurosci. Res , vol.35 , pp. 567-576
    • Brewer, G.J.1    Torricelli, J.R.2    Evege, E.K.3    Prive, P.J.4
  • 11
    • 0033152966 scopus 로고    scopus 로고
    • Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
    • Burdon, T., Stracey, C., Chambers, I., Nichols, J. and Smith, A. (1999). Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev. Biol. 210, 30-43.
    • (1999) Dev. Biol , vol.210 , pp. 30-43
    • Burdon, T.1    Stracey, C.2    Chambers, I.3    Nichols, J.4    Smith, A.5
  • 12
    • 0036709213 scopus 로고    scopus 로고
    • Signalling, cell cycle and pluripotency in embryonic stem cells
    • Burdon, T., Smith, A. and Savatier, P. (2002). Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 12, 432-438.
    • (2002) Trends Cell Biol , vol.12 , pp. 432-438
    • Burdon, T.1    Smith, A.2    Savatier, P.3
  • 13
    • 0035020950 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling pathways
    • Cantrell, D. A. (2001). Phosphoinositide 3-kinase signalling pathways. J. Cell Sci 114, 1439-1445.
    • (2001) J. Cell Sci , vol.114 , pp. 1439-1445
    • Cantrell, D.A.1
  • 14
    • 16844364151 scopus 로고    scopus 로고
    • LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
    • Cartwright, P., McLean, C., Sheppard, A., Rivett, D., Jones, K. and Dalton, S. (2005). LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development 132, 885-896.
    • (2005) Development , vol.132 , pp. 885-896
    • Cartwright, P.1    McLean, C.2    Sheppard, A.3    Rivett, D.4    Jones, K.5    Dalton, S.6
  • 15
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S. and Smith, A. (2003). Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643-655.
    • (2003) Cell , vol.113 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4    Lee, S.5    Tweedie, S.6    Smith, A.7
  • 19
    • 23744492188 scopus 로고    scopus 로고
    • Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
    • Condliffe, A., Davidson, K., Anderson, K., Ellson, C., Crabbe, T., Okkenhaug, K., Vanhaesebroeck, B., Turner, M., Webb, L., Wymann, M. et al. (2005). Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106, 1432-1440.
    • (2005) Blood , vol.106 , pp. 1432-1440
    • Condliffe, A.1    Davidson, K.2    Anderson, K.3    Ellson, C.4    Crabbe, T.5    Okkenhaug, K.6    Vanhaesebroeck, B.7    Turner, M.8    Webb, L.9    Wymann, M.10
  • 21
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans, M. J. and Kaufman, M. H. (1981). Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 24
    • 33748096426 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110[alpha] inhibitors
    • Hayakawa, M., Kaizawa, H., Moritomo, H., Koizumi, T., Ohishi, T., Okada, M., Ohta, M., Tsukamoto, S. i., Parker, P., Workman, P. et al. (2006). Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110[alpha] inhibitors. Bioorg. Med. Chem. 14, 6847-6858.
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 6847-6858
    • Hayakawa, M.1    Kaizawa, H.2    Moritomo, H.3    Koizumi, T.4    Ohishi, T.5    Okada, M.6    Ohta, M.7    Tsukamoto, S.I.8    Parker, P.9    Workman, P.10
  • 25
    • 32044466838 scopus 로고    scopus 로고
    • Exploiting the PI3K/AKT pathway for cancer drug discovery
    • Hennessy, B., Smith, D., Ram, P., Lu, Y. and Mills, G. (2005). Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 4, 988-1004.
    • (2005) Nat. Rev. Drug Discov , vol.4 , pp. 988-1004
    • Hennessy, B.1    Smith, D.2    Ram, P.3    Lu, Y.4    Mills, G.5
  • 29
    • 0037103988 scopus 로고    scopus 로고
    • Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells
    • Jirmanova, L., Afanassieff, M., Gobert-Gosse, S., Markossian, S. and Savatier, P. (2002). Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells. Oncogene 21, 5515-5528.
    • (2002) Oncogene , vol.21 , pp. 5515-5528
    • Jirmanova, L.1    Afanassieff, M.2    Gobert-Gosse, S.3    Markossian, S.4    Savatier, P.5
  • 30
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110 beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    • Kang, S., Denley, A., Vanhaesebroeck, B. and Vogt, P. K. (2006). Oncogenic transformation induced by the p110 beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. USA 103, 1289-1294.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3    Vogt, P.K.4
  • 32
    • 34548587064 scopus 로고    scopus 로고
    • FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage committment
    • Kunath, T., Saba-El-Leil, M. K., Almousailleakh, M., Wray, J., Meloche, S. and Smith, A. (2007). FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage committment. Development 134, 2895-2902.
    • (2007) Development , vol.134 , pp. 2895-2902
    • Kunath, T.1    Saba-El-Leil, M.K.2    Almousailleakh, M.3    Wray, J.4    Meloche, S.5    Smith, A.6
  • 35
    • 33947308285 scopus 로고    scopus 로고
    • How is pluripotency determined and maintained?
    • Niwa, H. (2007). How is pluripotency determined and maintained? Development 134, 635-646.
    • (2007) Development , vol.134 , pp. 635-646
    • Niwa, H.1
  • 36
    • 0032127977 scopus 로고    scopus 로고
    • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
    • Niwa, H., Burdon, T., Chambers, I. and Smith, A. (1998). Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 12, 2048-2060.
    • (1998) Genes Dev , vol.12 , pp. 2048-2060
    • Niwa, H.1    Burdon, T.2    Chambers, I.3    Smith, A.4
  • 38
    • 9144239955 scopus 로고    scopus 로고
    • Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
    • Paling, N. R., Wheadon, H., Bone, H. K. and Welham, M. J. (2004). Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J. Biol. Chem. 279, 48063-48070.
    • (2004) J. Biol. Chem , vol.279 , pp. 48063-48070
    • Paling, N.R.1    Wheadon, H.2    Bone, H.K.3    Welham, M.J.4
  • 41
    • 28444475519 scopus 로고    scopus 로고
    • Essential roles of sphongosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells
    • Pebay, A., Wong, R. C., Pitson, S. M., Wolvetang, E. J., Peh, G. S., Filipczyk, A., Koh, K. L., Tellis, I., Nguyen, L. T. and Pera, M. F. (2005). Essential roles of sphongosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. Stem Cells 23, 1541-1548.
    • (2005) Stem Cells , vol.23 , pp. 1541-1548
    • Pebay, A.1    Wong, R.C.2    Pitson, S.M.3    Wolvetang, E.J.4    Peh, G.S.5    Filipczyk, A.6    Koh, K.L.7    Tellis, I.8    Nguyen, L.T.9    Pera, M.F.10
  • 42
    • 33646483183 scopus 로고    scopus 로고
    • Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells
    • Pritsker, M., Ford, N., Jenq, H. and Lemischka, I. (2006). Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA 103, 6946-6951.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6946-6951
    • Pritsker, M.1    Ford, N.2    Jenq, H.3    Lemischka, I.4
  • 43
    • 33644864033 scopus 로고    scopus 로고
    • Neurotrophins mediate human embryonic stem cell survival
    • Pyle, A., Lock, L. and Donovan, P. (2006). Neurotrophins mediate human embryonic stem cell survival. Nat. Biotech. 24, 344-350.
    • (2006) Nat. Biotech , vol.24 , pp. 344-350
    • Pyle, A.1    Lock, L.2    Donovan, P.3
  • 44
    • 23944508588 scopus 로고    scopus 로고
    • The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo
    • Riley, J. K., Carayannopoulos, M. O., Wyman, A. H., Chi, M., Ratajczak, C. K. and Moley, K. H. (2005). The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo. Dev. Biol. 284, 377-386.
    • (2005) Dev. Biol , vol.284 , pp. 377-386
    • Riley, J.K.1    Carayannopoulos, M.O.2    Wyman, A.H.3    Chi, M.4    Ratajczak, C.K.5    Moley, K.H.6
  • 45
    • 33646823663 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-Kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts
    • Riley, J. K., Carayannopoulos, M. O., Wyman, A. H., Chi, M. and Moley, K. H. (2006). Phosphatidylinositol 3-Kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts. J. Biol. Chem. 281, 6010-6019.
    • (2006) J. Biol. Chem , vol.281 , pp. 6010-6019
    • Riley, J.K.1    Carayannopoulos, M.O.2    Wyman, A.H.3    Chi, M.4    Moley, K.H.5
  • 46
    • 0028584245 scopus 로고
    • The phosphatidylinositol 3-kinase-Alpha is required for DNA-synthesis induced by some, but not all, growth-factors
    • Roche, S., Koegl, M. and Courtneidge, S. A. (1994). The phosphatidylinositol 3-kinase-Alpha is required for DNA-synthesis induced by some, but not all, growth-factors. Proc. Natl. Acad. Sci. USA 91, 9185-9189.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9185-9189
    • Roche, S.1    Koegl, M.2    Courtneidge, S.A.3
  • 47
    • 0031725052 scopus 로고    scopus 로고
    • A function for phosphatidylinositol 3-kinase beta (p85 alpha-p110 beta) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction
    • Roche, S., Downward, J., Raynal, P. and Courtneidge, S. A. (1998). A function for phosphatidylinositol 3-kinase beta (p85 alpha-p110 beta) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction. Mol. Cell. Biol. 18, 7119-7129.
    • (1998) Mol. Cell. Biol , vol.18 , pp. 7119-7129
    • Roche, S.1    Downward, J.2    Raynal, P.3    Courtneidge, S.A.4
  • 49
    • 0032538051 scopus 로고    scopus 로고
    • Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells
    • Rottenberg, H. and Wu, S. L. (1998). Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells. BBA-Mol. Cell Res. 1404, 393-404.
    • (1998) BBA-Mol. Cell Res , vol.1404 , pp. 393-404
    • Rottenberg, H.1    Wu, S.L.2
  • 50
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase {delta} in Neutrophil directional movement
    • Sadhu, C., Masinovsky, B., Dick, K., Sowell, C. G. and Staunton, D. E. (2003). Essential role of phosphoinositide 3-kinase {delta} in Neutrophil directional movement. J. Immunol. 170, 2647-2654.
    • (2003) J. Immunol , vol.170 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 51
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • Sato, N., Meijer, L., Skaltsounis, L., Greengard, P. and Brivanlou, A. H. (2004). Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10, 55-63.
    • (2004) Nat. Med , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 52
    • 0035189927 scopus 로고    scopus 로고
    • Embryo-derived stem cells: Of mice and men
    • Smith, A. G. (2001). Embryo-derived stem cells: of mice and men. Ann. Rev. Cell Dev. Biol. 17, 435-462.
    • (2001) Ann. Rev. Cell Dev. Biol , vol.17 , pp. 435-462
    • Smith, A.G.1
  • 53
    • 34548596749 scopus 로고    scopus 로고
    • A discrete period of FGF-induced Erk1/2 signalling is required fro vertebrate neural specification
    • Stavridis, M., Lunn, J. S., Collins, B. J. and Storey, K. G. (2007). A discrete period of FGF-induced Erk1/2 signalling is required fro vertebrate neural specification. Development 134, 2889-2894.
    • (2007) Development , vol.134 , pp. 2889-2894
    • Stavridis, M.1    Lunn, J.S.2    Collins, B.J.3    Storey, K.G.4
  • 55
    • 13044305289 scopus 로고    scopus 로고
    • PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-trisphosphate and Akt/protein kinase B signaling pathway
    • Sun, H., Lesche, R., Li, D. M., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X. and Wu, H. (1999). PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-trisphosphate and Akt/protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 96, 6199-6204.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6199-6204
    • Sun, H.1    Lesche, R.2    Li, D.M.3    Liliental, J.4    Zhang, H.5    Gao, J.6    Gavrilova, N.7    Mueller, B.8    Liu, X.9    Wu, H.10
  • 56
    • 0038100185 scopus 로고    scopus 로고
    • Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
    • Takahashi, K., Mitsui, K. and Yamanaka, S. (2003). Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature 423, 541-545.
    • (2003) Nature , vol.423 , pp. 541-545
    • Takahashi, K.1    Mitsui, K.2    Yamanaka, S.3
  • 57
    • 0033604577 scopus 로고    scopus 로고
    • Signaling by distinct classes of phosphoinositide 3-kinases
    • Vanhaesebroeck, B. and Waterfield, M. D. (1999). Signaling by distinct classes of phosphoinositide 3-kinases. Exp. Cell Res. 253, 239-254.
    • (1999) Exp. Cell Res , vol.253 , pp. 239-254
    • Vanhaesebroeck, B.1    Waterfield, M.D.2
  • 60
    • 4043067193 scopus 로고    scopus 로고
    • Gene targeting: Attention to detail
    • Vanhaesebroeck, B., Rohn, J. L. and Waterfield, M. D. (2004). Gene targeting: attention to detail. Cell 118, 274-276.
    • (2004) Cell , vol.118 , pp. 274-276
    • Vanhaesebroeck, B.1    Rohn, J.L.2    Waterfield, M.D.3
  • 61
    • 33646549601 scopus 로고    scopus 로고
    • Activation of Akt signalling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells
    • Watanabe, S., Umehara, H., Murayama, K., Okabe, M., Kimura, T. and Nakano, K. (2006). Activation of Akt signalling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene 25, 2697-2707.
    • (2006) Oncogene , vol.25 , pp. 2697-2707
    • Watanabe, S.1    Umehara, H.2    Murayama, K.3    Okabe, M.4    Kimura, T.5    Nakano, K.6
  • 62
    • 0028068607 scopus 로고
    • Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3b-kinase
    • Welham, M. J., Dechert, U., Leslie, K. B., Jirik, F. and Schrader, J. W. (1994). Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3b-kinase. J. Biol. Chem. 269, 23764-23768.
    • (1994) J. Biol. Chem , vol.269 , pp. 23764-23768
    • Welham, M.J.1    Dechert, U.2    Leslie, K.B.3    Jirik, F.4    Schrader, J.W.5
  • 63
    • 34247099723 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases and regulation of embryonic stem cell fate
    • Welham, M. J., Storm, M. P., Kingham, E. and Bone, H. K. (2007). Phosphoinositide 3-kinases and regulation of embryonic stem cell fate. Biochem. Soc. Trans. 35, 225-228.
    • (2007) Biochem. Soc. Trans , vol.35 , pp. 225-228
    • Welham, M.J.1    Storm, M.P.2    Kingham, E.3    Bone, H.K.4
  • 64
    • 0034176579 scopus 로고    scopus 로고
    • The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
    • Williams, M. R., Arthur, J. S., Balendran, A., van der Kaay, J., Poli, V., Cohen, P. and Alessi, D. R. (2000). The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10, 439-448.
    • (2000) Curr. Biol , vol.10 , pp. 439-448
    • Williams, M.R.1    Arthur, J.S.2    Balendran, A.3    van der Kaay, J.4    Poli, V.5    Cohen, P.6    Alessi, D.R.7
  • 65
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cell into neuroectoderma precursos in adherent monoculture
    • Ying, Q. L., Stavridis, M., Griffiths, D., Li, M. and Smith, A. (2003a). Conversion of embryonic stem cell into neuroectoderma precursos in adherent monoculture. Nat. Biotech. 21, 183-186.
    • (2003) Nat. Biotech , vol.21 , pp. 183-186
    • Ying, Q.L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 66
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • Ying, Q. L., Nichols, J., Chambers, I. and Smith, A. (2003b). BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115, 281-292.
    • (2003) Cell , vol.115 , pp. 281-292
    • Ying, Q.L.1    Nichols, J.2    Chambers, I.3    Smith, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.