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Volumn 16, Issue 1, 2009, Pages 15-27

Involvement of GSK-3 in Regulation of Murine Embryonic Stem Cell Self-Renewal Revealed by a Series of Bisindolylmaleimides

Author keywords

CHEMBIO; SIGNALING; STEMCELL

Indexed keywords

BISINDOLYLMALEIMIDE; GLYCOGEN SYNTHASE KINASE 3; INDOLE DERIVATIVE; LEUKEMIA INHIBITORY FACTOR; MALEIMIDE DERIVATIVE;

EID: 58549109668     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2008.11.003     Document Type: Article
Times cited : (53)

References (50)
  • 1
    • 3843055775 scopus 로고    scopus 로고
    • The Src family of tyrosine kinases is important for embryonic stem cell self-renewal
    • Anneren C., Cowan C.A., and Melton D.A. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J. Biol. Chem. 279 (2004) 31590-31598
    • (2004) J. Biol. Chem. , vol.279 , pp. 31590-31598
    • Anneren, C.1    Cowan, C.A.2    Melton, D.A.3
  • 2
    • 35548941791 scopus 로고    scopus 로고
    • β-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells
    • Anton R., Kestler H.A., and Kuhl M. β-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells. FEBS Lett. 581 (2007) 5247-5254
    • (2007) FEBS Lett. , vol.581 , pp. 5247-5254
    • Anton, R.1    Kestler, H.A.2    Kuhl, M.3
  • 3
    • 33744758028 scopus 로고    scopus 로고
    • The role of PI3K/AKT, MAPK/ERK and NFκβ signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis
    • Armstrong L., Hughes O., Young S.G., Hyslop L., Stewart R., Wappler I., Peters H., Walter T., Stojkovic P., Evans J., et al. The role of PI3K/AKT, MAPK/ERK and NFκβ signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Hum. Mol. Genet. 15 (2006) 1894-1913
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1894-1913
    • Armstrong, L.1    Hughes, O.2    Young, S.G.3    Hyslop, L.4    Stewart, R.5    Wappler, I.6    Peters, H.7    Walter, T.8    Stojkovic, P.9    Evans, J.10
  • 5
    • 0030875352 scopus 로고    scopus 로고
    • Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells
    • Boeuf H., Hauss C., DeGraeve F., Baran N., and Kedinger C. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J. Cell Biol. 138 (1997) 1207-1217
    • (1997) J. Cell Biol. , vol.138 , pp. 1207-1217
    • Boeuf, H.1    Hauss, C.2    DeGraeve, F.3    Baran, N.4    Kedinger, C.5
  • 6
    • 0035824552 scopus 로고    scopus 로고
    • The ribosomal S6 kinases, cAMP-responsive element-binding, and STAT3 proteins are regulated by different leukemia inhibitory factor signaling pathways in mouse embryonic stem cells
    • Boeuf H., Merienne K., Jacquot S., Duval D., Zeniou M., Hauss C., Reinhardt B., Huss-Garcia Y., Dierich A., Frank D.A., et al. The ribosomal S6 kinases, cAMP-responsive element-binding, and STAT3 proteins are regulated by different leukemia inhibitory factor signaling pathways in mouse embryonic stem cells. J. Biol. Chem. 276 (2001) 46204-46211
    • (2001) J. Biol. Chem. , vol.276 , pp. 46204-46211
    • Boeuf, H.1    Merienne, K.2    Jacquot, S.3    Duval, D.4    Zeniou, M.5    Hauss, C.6    Reinhardt, B.7    Huss-Garcia, Y.8    Dierich, A.9    Frank, D.A.10
  • 7
    • 27644483064 scopus 로고    scopus 로고
    • Regulatory networks in embryo-derived pluripotent stem cells
    • Boiani M., and Schoeler H.R. Regulatory networks in embryo-derived pluripotent stem cells. Nat. Rev. Mol. Cell Biol. 6 (2005) 872-881
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 872-881
    • Boiani, M.1    Schoeler, H.R.2
  • 8
    • 0033152966 scopus 로고    scopus 로고
    • Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
    • Burdon T., Stracey C., Chambers I., Nichols J., and Smith A. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev. Biol. 210 (1999) 30-43
    • (1999) Dev. Biol. , vol.210 , pp. 30-43
    • Burdon, T.1    Stracey, C.2    Chambers, I.3    Nichols, J.4    Smith, A.5
  • 9
    • 0036709213 scopus 로고    scopus 로고
    • Signalling, cell cycle and pluripotency in embryonic stem cells
    • Burdon T., Smith A., and Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 12 (2002) 432-438
    • (2002) Trends Cell Biol. , vol.12 , pp. 432-438
    • Burdon, T.1    Smith, A.2    Savatier, P.3
  • 10
    • 16844364151 scopus 로고    scopus 로고
    • LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
    • Cartwright P., McLean C., Sheppard A., Rivett D., Jones K., and Dalton S. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development 132 (2005) 885-896
    • (2005) Development , vol.132 , pp. 885-896
    • Cartwright, P.1    McLean, C.2    Sheppard, A.3    Rivett, D.4    Jones, K.5    Dalton, S.6
  • 11
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • Chambers I., Colby D., Robertson M., Nichols J., Lee S., Tweedie S., and Smith A. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113 (2003) 643-655
    • (2003) Cell , vol.113 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4    Lee, S.5    Tweedie, S.6    Smith, A.7
  • 14
    • 41149174852 scopus 로고    scopus 로고
    • Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells
    • Cole M.F., Johnstone S.E., Newman J.J., Kagey M.H., and Young R.A. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev. 22 (2008) 746-755
    • (2008) Genes Dev. , vol.22 , pp. 746-755
    • Cole, M.F.1    Johnstone, S.E.2    Newman, J.J.3    Kagey, M.H.4    Young, R.A.5
  • 15
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351 (2000) 95-105
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 17
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: tricks of the trade for a multi-tasking kinase
    • Doble B.W., and Woodgett J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci. 116 (2003) 1175-1186
    • (2003) J. Cell Sci. , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 18
    • 34249311572 scopus 로고    scopus 로고
    • Functional redundancy of GSK-3α and GSK-3β in Wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines
    • Doble B.W., Patel S., Wood G.A., Kockeritz L.K., and Woodgett J.R. Functional redundancy of GSK-3α and GSK-3β in Wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev. Cell 12 (2007) 957-971
    • (2007) Dev. Cell , vol.12 , pp. 957-971
    • Doble, B.W.1    Patel, S.2    Wood, G.A.3    Kockeritz, L.K.4    Woodgett, J.R.5
  • 19
    • 28444438841 scopus 로고    scopus 로고
    • Defining the role of Wnt/β-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells
    • Dravid G., Ye Z., Hammond H., Chen G., Pyle A., Donovan P., Yu X., and Cheng L. Defining the role of Wnt/β-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells 23 (2005) 1489-1501
    • (2005) Stem Cells , vol.23 , pp. 1489-1501
    • Dravid, G.1    Ye, Z.2    Hammond, H.3    Chen, G.4    Pyle, A.5    Donovan, P.6    Yu, X.7    Cheng, L.8
  • 20
    • 0029923977 scopus 로고    scopus 로고
    • gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/Mitogen-activated protein kinase pathways
    • Ernst M., Oates A., and Dunn A.R. gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/Mitogen-activated protein kinase pathways. J. Biol. Chem. 271 (1996) 30136-30143
    • (1996) J. Biol. Chem. , vol.271 , pp. 30136-30143
    • Ernst, M.1    Oates, A.2    Dunn, A.R.3
  • 21
    • 30544450976 scopus 로고    scopus 로고
    • WNT/β-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells
    • Hao J., Li T.G., Qi X., Zhao D.F., and Zhao G.Q. WNT/β-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev. Biol. 290 (2006) 81-91
    • (2006) Dev. Biol. , vol.290 , pp. 81-91
    • Hao, J.1    Li, T.G.2    Qi, X.3    Zhao, D.F.4    Zhao, G.Q.5
  • 22
    • 47949127436 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growth
    • Holmes T., O'Brien T.A., Knight R., Lindeman R., Shen S., Song E.K., Symonds G., and Dolnikov A. Glycogen synthase kinase-3β inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growth. Stem Cells 26 (2008) 1288-1297
    • (2008) Stem Cells , vol.26 , pp. 1288-1297
    • Holmes, T.1    O'Brien, T.A.2    Knight, R.3    Lindeman, R.4    Shen, S.5    Song, E.K.6    Symonds, G.7    Dolnikov, A.8
  • 23
    • 0037103988 scopus 로고    scopus 로고
    • Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells
    • Jirmanova L., Afanassieff M., Gobert-Gosse S., Markossian S., and Savatier P. Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells. Oncogene 21 (2002) 5515-5528
    • (2002) Oncogene , vol.21 , pp. 5515-5528
    • Jirmanova, L.1    Afanassieff, M.2    Gobert-Gosse, S.3    Markossian, S.4    Savatier, P.5
  • 24
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope R.S., and Johnson G.V.W. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem. Sci. 29 (2004) 95-102
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.W.2
  • 25
    • 0141567462 scopus 로고    scopus 로고
    • Synthesis and discovery of macrocyclic polyoxygenated B-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3β inhibitors
    • Kuo G.-H., Prouty C., DeAngelis A., Shen L., O'Neill D.J., Shah C., Connolly P.J., Murray W.V., Conway B.R., Cheung P., et al. Synthesis and discovery of macrocyclic polyoxygenated B-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3β inhibitors. J. Med. Chem. 46 (2003) 4021-4031
    • (2003) J. Med. Chem. , vol.46 , pp. 4021-4031
    • Kuo, G.-H.1    Prouty, C.2    DeAngelis, A.3    Shen, L.4    O'Neill, D.J.5    Shah, C.6    Connolly, P.J.7    Murray, W.V.8    Conway, B.R.9    Cheung, P.10
  • 26
    • 0033517123 scopus 로고    scopus 로고
    • STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
    • Matsuda T., Nakamura T., Nakao K., Arai T., Katsuki M., Heike T., and Yokota T. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J. 18 (1999) 4261-4269
    • (1999) EMBO J. , vol.18 , pp. 4261-4269
    • Matsuda, T.1    Nakamura, T.2    Nakao, K.3    Arai, T.4    Katsuki, M.5    Heike, T.6    Yokota, T.7
  • 29
    • 33947308285 scopus 로고    scopus 로고
    • How is pluripotency determined and maintained?
    • Niwa H. How is pluripotency determined and maintained?. Development 134 (2007) 635-646
    • (2007) Development , vol.134 , pp. 635-646
    • Niwa, H.1
  • 30
    • 0032127977 scopus 로고    scopus 로고
    • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
    • Niwa H., Burdon T., Chambers I., and Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 12 (1998) 2048-2060
    • (1998) Genes Dev. , vol.12 , pp. 2048-2060
    • Niwa, H.1    Burdon, T.2    Chambers, I.3    Smith, A.4
  • 32
    • 4444361024 scopus 로고    scopus 로고
    • β-catenin signalling is required for neural differentiation of embryonic stem cells
    • Otero J.J., Fu W., Kan L., Cuadra A.E., and Kessler J.A. β-catenin signalling is required for neural differentiation of embryonic stem cells. Development 131 (2004) 3545-3557
    • (2004) Development , vol.131 , pp. 3545-3557
    • Otero, J.J.1    Fu, W.2    Kan, L.3    Cuadra, A.E.4    Kessler, J.A.5
  • 33
    • 9144239955 scopus 로고    scopus 로고
    • Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
    • Paling N.R., Wheadon H., Bone H.K., and Welham M.J. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J. Biol. Chem. 279 (2004) 48063-48070
    • (2004) J. Biol. Chem. , vol.279 , pp. 48063-48070
    • Paling, N.R.1    Wheadon, H.2    Bone, H.K.3    Welham, M.J.4
  • 34
    • 33644864033 scopus 로고    scopus 로고
    • Neurotrophins mediate human embryonic stem cell survival
    • Pyle A.D., Lock L.F., and Donovan P.J. Neurotrophins mediate human embryonic stem cell survival. Nat. Biotechnol. 24 (2006) 344-350
    • (2006) Nat. Biotechnol. , vol.24 , pp. 344-350
    • Pyle, A.D.1    Lock, L.F.2    Donovan, P.J.3
  • 35
    • 1942533517 scopus 로고    scopus 로고
    • BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways
    • Qi X., Li T.-G., Hao J., Hu J., Simmons H., Miura S., Mishina Y., and Zhao G.-Q. BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc. Natl. Acad. Sci. USA 101 (2004) 6027-6032
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6027-6032
    • Qi, X.1    Li, T.-G.2    Hao, J.3    Hu, J.4    Simmons, H.5    Miura, S.6    Mishina, Y.7    Zhao, G.-Q.8
  • 37
    • 0032212348 scopus 로고    scopus 로고
    • An assay for glycogen synthase kinase 3 (GSK-3) for use in crude cell extracts
    • Ryves W.J., Fryer L., Dale T., and Harwood A.J. An assay for glycogen synthase kinase 3 (GSK-3) for use in crude cell extracts. Anal. Biochem. 264 (1998) 124-127
    • (1998) Anal. Biochem. , vol.264 , pp. 124-127
    • Ryves, W.J.1    Fryer, L.2    Dale, T.3    Harwood, A.J.4
  • 38
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signalling by a pharmacological GSK-3-specific inhibitor
    • Sato N., Meijer L., Skaltsounis L., Greengard P., and Brivanlou A.H. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signalling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10 (2004) 55-63
    • (2004) Nat. Med. , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 40
    • 0035189927 scopus 로고    scopus 로고
    • Embryo-derived stem cells: of mice and men
    • Smith A.G. Embryo-derived stem cells: of mice and men. Annu. Rev. Cell Dev. Biol. 17 (2001) 435-462
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 435-462
    • Smith, A.G.1
  • 41
    • 0023256867 scopus 로고
    • Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells
    • Smith A.G., and Hooper M.L. Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells. Dev. Biol. 121 (1987) 1-9
    • (1987) Dev. Biol. , vol.121 , pp. 1-9
    • Smith, A.G.1    Hooper, M.L.2
  • 42
    • 0024245022 scopus 로고
    • Inhibition of pluripotential embryonic stem-cell differentiation by purified polypeptides
    • Smith A.G., Heath J.K., Donaldson D.D., Wong G.G., Moreau J., Stahl M., and Rogers D. Inhibition of pluripotential embryonic stem-cell differentiation by purified polypeptides. Nature 336 (1988) 688-690
    • (1988) Nature , vol.336 , pp. 688-690
    • Smith, A.G.1    Heath, J.K.2    Donaldson, D.D.3    Wong, G.G.4    Moreau, J.5    Stahl, M.6    Rogers, D.7
  • 44
    • 13044305289 scopus 로고    scopus 로고
    • PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt protein kinase B signaling pathway
    • Sun H., Lesche R., Li D.M., Liliental J., Zhang H., Gao J., Gavrilova N., Mueller B., Liu X., and Wu H. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 96 (1999) 6199-6204
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6199-6204
    • Sun, H.1    Lesche, R.2    Li, D.M.3    Liliental, J.4    Zhang, H.5    Gao, J.6    Gavrilova, N.7    Mueller, B.8    Liu, X.9    Wu, H.10
  • 45
    • 0038100185 scopus 로고    scopus 로고
    • Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
    • Takahashi K., Mitsui K., and Yamanaka S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature 423 (2003) 541-545
    • (2003) Nature , vol.423 , pp. 541-545
    • Takahashi, K.1    Mitsui, K.2    Yamanaka, S.3
  • 46
    • 33748702122 scopus 로고    scopus 로고
    • The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes
    • Tseng A.-S., Engel F.B., and Keating M.T. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem. Biol. 13 (2006) 957-963
    • (2006) Chem. Biol. , vol.13 , pp. 957-963
    • Tseng, A.-S.1    Engel, F.B.2    Keating, M.T.3
  • 47
    • 33646549601 scopus 로고    scopus 로고
    • Activation of Akt signalling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells
    • Watanabe S., Umehara H., Murayama K., Okabe M., Kimura T., and Nakano K. Activation of Akt signalling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene 25 (2006) 2697-2707
    • (2006) Oncogene , vol.25 , pp. 2697-2707
    • Watanabe, S.1    Umehara, H.2    Murayama, K.3    Okabe, M.4    Kimura, T.5    Nakano, K.6
  • 48
    • 0028123081 scopus 로고
    • Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation
    • Welham M.J., Duronio V., Leslie K.B., Bowtell D., and Schrader J.W. Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation. J. Biol. Chem. 269 (1994) 21165-21176
    • (1994) J. Biol. Chem. , vol.269 , pp. 21165-21176
    • Welham, M.J.1    Duronio, V.2    Leslie, K.B.3    Bowtell, D.4    Schrader, J.W.5
  • 49
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • Ying Q.-L., Nichols J., Chambers I., and Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115 (2003) 281-292
    • (2003) Cell , vol.115 , pp. 281-292
    • Ying, Q.-L.1    Nichols, J.2    Chambers, I.3    Smith, A.4


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