Identification, characterization, and function of a novel oncogene: The peripheral cannabinoid receptor Cb2

Annals of the New York Academy of Sciences

Volumn 996, Issue , 2003, Pages 10-16

  Jordà, Meritxell Alberich ^a   Rayman, Nazik ^a   Valk, Peter ^a   De Wee, Eva ^a   Delwel, Ruud ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Acute myeloid leukemia; Common virus integration site; Migration; Neutrophilic differentiation; Peripheral cannabinoid receptor Cb2; Retroviral insertional mutagenesis

Indexed keywords

2 ARACHIDONOYLGLYCEROL; CANNABINOID; CANNABINOID 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; RETROVIRUS VECTOR; RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; B LYMPHOCYTE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL MIGRATION; CLINICAL ARTICLE; CONFERENCE PAPER; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC CODE; HUMAN; HUMAN CELL; MOUSE; MURINE LEUKEMIA; MUTAGENESIS; NEUTROPHIL; NONHUMAN; ONCOGENE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTO ONCOGENE; RNA TRANSCRIPTION; STEM CELL;

ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0038806692     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb03227.x     Document Type: Conference Paper

References (7)

1. JOOSTEN, M., Y. VANKAN-BERKHOUDT, M. TAS, et al. 2002. Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites. Oncogene 21: 7247-7255.
2. MATSUDA, L.A., S.F. LOLAIT, M.J. BROWNSTEIN, et al. 1990. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564.
3. MUNRO, S., K.L. THOMAS, M. ABU-SHAAR. 1993. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61-65.
4. LYNN, A.B. & M. HERKENHAM. 1994. Localization of cannabinoid receptors and non-saturable high-density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor-mediated immune modulation by cannabinoids. J. Pharmacol. Exp. Ther. 268: 1612-1623.
5. CARAYON, P., J. MARCHAND, D. DUSSOSSOY, et al. 1998. Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood 92: 3605-3615.
6. GALIEGUE, S., S. MARY, J. MARCHAND, et al. 1995. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem. 232: 54-61.
7. JORDÀ, M.A., S.E. VERBAKEL, P.J. VALK, et al. 2002. Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol. Blood 99: 2786-2793.