The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis

Cell Death and Differentiation

Volumn 10, Issue 9, 2003, Pages 946-955

  Maccarrone, M ^a   Finazzi Agro A ^b  

^a UNIVERSITY OF TERAMO   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Brain development; Cannabinoid receptors; Cell differentiation; Metabolism; Neurogenesis; Signal transduction; Vanilloid receptors

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABIS DERIVATIVE; FATTY ACID AMIDASE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; PROTEIN KINASE C; TETRAHYDROCANNABINOL; VANILLOID RECEPTOR;

ANIMAL CELL; APOPTOSIS; BRAIN DEVELOPMENT; CANCER INHIBITION; ENZYME DEGRADATION; GENE TARGETING; HORMONAL REGULATION; HUMAN; HUMAN CELL; MALE INFERTILITY; MAMMAL CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SKIN TUMOR; SYNTHESIS;

ANIMALS; APOPTOSIS; ARACHIDONIC ACIDS; CELL DIFFERENTIATION; ENDOCANNABINOIDS; MAMMALS; MODELS, CHEMICAL; NEURONS; POLYUNSATURATED ALKAMIDES; SIGNAL TRANSDUCTION;

ANIMALIA; CANNABIS; CANNABIS SATIVA; MAMMALIA;

EID: 0041411118     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401284     Document Type: Review

References (55)

1. McAllister SD and Glass M (2002) CB1 and CB2 receptor-mediated signalling: a focus on endocannabinoids. Prostaglandins Leukot. Essent. Fatty Acids 66: 161-171
2. Mechoulam R, Panikashvili D and Shohami E (2002) Cannabinoids and brain injury: therapeutic implications. Trends Mol. Med. 8: 58-61
3. Di Marzo V (1998) 'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance. Biochim. Biophys. Acta 1392: 153-175
4. Maccarrone M and Finazzi-Agró A (2002) Endocannabinoids and their actions. Vitam. Horm. 65: 225-255
5. Pertwee RG (2001) Cannabinoid receptors and pain. Prog. Neurobiol. 63: 569-611
6. Sugiura T, Kobayashi Y, Oka S and Waku K (2002) Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot. Essent. Fatty Acids 66: 173-192
7. Hanus L, Abu-Lafi S, Fride E, Breuer A, Vogel Z, Shalev DE, Kustanovich I and Mechoulam R (2001) 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc. Natl. Acad. Sci. USA 98: 3662-3665
8. MacDonald JC and Vaughan CW (2001) Cannabinoids act backwards. Nature 410: 527-530
9. Wilson RI and Nicoll RA (2002) Endocannabinoid signaling in the brain. Science 296: 678-682
10. Dinh TP, Carpenter D, Leslie FM, Freund TF, Katona I, Sensi SL, Kathuria S and Piomelli D (2002) Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc. Natl. Acad. Sci. USA 99: 10819-10824
11. Hansen HH, Hansen SH, Schousboe A and Hansen HS (2000) Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons. J. Neurochem. 75: 861-871
12. Hillard CJ and Jarrahian A (2000) The movement of N-arachidonoyl-ethanolamine (anandamide) across cellular membranes. Chem. Phys. Lipids 108: 123-134
13. Maccarrone M, Bari M, Battista N and Finazzi-Agró A (2002) Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. Blood 100: 4040-4048
14. Bracey MH, Hanson MA, Masuda KR, Stevens RC and Cravatt BF (2002) Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science 298: 1793-1796
15. Ueda N, Puffenbarger RA, Yamamoto S and Deutsch DG (2000) The fatty acid amide hydrolase (FAAH). Chem. Phys. Lipids 108: 107-121
16. Deutsch DG, Glaser ST, Howell JM, Kunz JS, Puffenbarger RA, Hillard CJ and Abumrad N (2001) The cellular uptake of anandamide is coupled to its breakdown by fatty acid amide hydrolase (FAAH). J. Biol. Chem. 276: 6967-6973
17. Day TA, Rakhshan F, Deutsch DG and Barker EL (2001) Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. Mol. Pharmacol. 59: 1369-1375
18. Van der Stelt M, van Kuik JA, Bari M, van Zadelhoff G, Leeflang BR, Veldink GA, Finazzi Agró A, Vliegenthart JFG and Maccarrone M (2002) Oxygenated metabolites of anandamide and 2-arachidonoyl-glycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter and fatty acid amide hydrolase. J. Med. Chem. 45: 3709-3720
19. Mukhopadhyay S and Howlett AC (2001) CB1 receptor-G protein association Subtype selectivity is determined by distinct intracellular domains. Eur. J. Biochem. 268: 499-505
20. Reggio PH and Traore H (2000) Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase. Chem. Phys. Lipids 108: 15-35
21. Khanolkar AD, Palmer SL and Makriyannis A (2000) Molecular probes for the cannabinoid receptors. Chem. Phys. Lipids 108: 37-52
22. Jordt SE and Julius D (2002) Molecular basis for species-specific sensitivity to 'hot' chili peppers. Cell 108: 421-430
23. Di Marzo V, Bisogno T and De Petrocellis L (2001) Anandamide: some like it hot. Trends Pharmacol. Sci. 22: 346-349
24. De Petrocellis L, Bisogno T, Maccarrone M, Davis JB, Finazzi-Agró A and Di Marzo V (2001) The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem. 276: 12856-12863
25. De Petrocellis L, Melck D, Palmisano A, Bisogno T, Laezza C, Bifulco M and Di Marzo V (1998) The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proc. Natl. Acad. Sci. USA 95: 8375-8380
26. Melck D, Rueda D, Galve-Roperh I, De Petrocellis L, Guzman M and Di Marzo V (1999) Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells. FEBS Lett. 463: 235-240
27. Melck D, De Petrocellis L, Orlando P, Bisogno T, Laezza C, Bifulco M and Di Marzo V (2000) Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. Endocrinology 141: 118-126
28. Bifulco M, Laezza C, Portella G, Vitale M, Orlando P, De Petrocellis L and Di Marzo V (2001) Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. FASEB J. 15: 2745-2747.
29. Derocq J-M, Bouaboula M, Marchand J, Rinaldi-Carmona M, Ségui M and Casellas P (1998) The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. FEBS Lett. 425: 419-425
30. Schwarz H, Blanco FJ and Lotz M (1994) Anandamide, an endogenous cannabinoid receptor agonist, inhibits lymphocyte proliferation and induces apoptosis. J. Neuroimmunol. 55: 107-115
31. Sarker KP, Obara S, Nakata M, Kitajima I and Maruyama I (2000) Anandamide induces apoptosis of PC-12 cells: involvement of superoxide and caspase-3. FEBS Lett. 472: 39-44
32. Galve-Roperh I, Sànchez C, Cortes ML, Gómez del Pulgar T, Izquierdo M and Guzman M (2000) Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat. Med. 6: 313-316
33. 9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Lett. 436: 6-10
34. 9-tetrahydrocannabinol. J. Neurosci. 18: 5322-5332
35. Ruiz L, Miguel A and Diaz-Laviada I (1999) Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. FEBS Lett. 458: 400-404
36. 2 cannabinoid receptor. Cancer Res. 61: 5784-5789
37. Sànchez C, Rueda D, Segui B, Galve-Roperh I, Levade T and Guzman M (2001) The CB1 cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein FAN. Mol. Pharmacol. 59: 955-959
38. Rueda D, Galve-Roperh I, Haro A and Guzman M (2000) The CB1 cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase. Mol. Pharmacol. 58: 814-820
39. Gómez del Pulgar T, Velasco G, Sanchez C, Haro A and Guzman M (2002) De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem J. 363: 183-188
40. Gómez del Pulgar T, Velasco G and Guzman M (2000) The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem. J. 347: 369-373
41. Gómez del Pulgar T, De Ceballos ML, Guzman M and Velasco G (2002) Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 277: 36527-36533
42. Galve-Roperh I, Rueda D, Gomez del Pulgar T, Velasco G and Guzman M (2002) Mechanism of extracellular signal-regulated kinase activation by the CB1 cannabinoid receptor. Mol. Pharmacol. 62: 1385-1392
43. Maccarrone M, Lorenzon T, Bari M, Melino G and Finazzi-Agró A (2000) Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J. Biol. Chem. 275: 31938-31945
44. Wahl GM and Carr AM (2001) The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat. Cell Biol. 3: 277-286
45. Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V and Iuvone T (2002) The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation. J. Biol. Chem. 277: 50348-50354
46. Jacobsson SO, Wallin T and Fowler CJ (2001) Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J. Pharmacol. Exp. Ther. 299: 951-959
47. Maccarrone M, Cecconi S, Rossi G, Battista N, Pauselli R and Finazzi-Agró A (2003) Anandamide activity and degradation are regulated by early postnatal ageing and follicle-stimulating hormone in mouse Sertoli cells. Endocrinology 144: 20-28
48. Casanova ML, Blazquez C, Martinez-Palacio J, Villanueva C, Fernandez-Acenero MJ, Huffman JW, Jorcano JL and Guzman M (2003) Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J. Clin. Invest. 111: 43-50
49. Maccarrone M, Pauselli R, Di Rienzo M and Finazzi-Agró A (2002) Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells. Biochem. J. 366: 137-144
50. Casaccia-Bonnefil P, Kong H and Chao MV (1999) Neurotrophins: the biological paradox of survival factors eliciting apoptosis. Cell Death Differ. 5: 357-364
51. Fernandez-Ruiz J, Berrendero F, Hernandez ML and Ramos JA (2000) The endogenous cannabinoid system and brain development. Trends Neurosci. 23: 14-20
52. Rueda D, Navarro B, Martinez-Serrano A, Guzman M and Galve-Roperh I (2002) The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway. J. Biol. Chem. 277: 46645-46650
53. Williams EJ, Walsh FS and Doherty P (2003) The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response. J. Cell Biol. 160: 481-486
54. Bifulco M and Di Marzo V (2002) Targeting the endocannabinoid system in cancer therapy: a call for further research. Nat. Med. 8: 547-550
55. McKallip RJ, Lombard C, Fisher M, Martin BR, Ryu S, Grant S, Nagarkatti PS and Nagarkatti M (2002) Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100: 627-634