PPAR-γ: A nuclear receptor with affinity for cannabinoids

Life Sciences

Volumn 77, Issue 14, 2005, Pages 1674-1684

  Burstein, Sumner ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Ajulemic acid; Cannabinoid; PPAR ; Receptor

Indexed keywords

AJULEMIC ACID; ANANDAMIDE; ANTIDIABETIC AGENT; CANNABINOID; CANNABINOID RECEPTOR; CELL NUCLEUS RECEPTOR; DICLOFENAC; ENDOCANNABINOID; LIPID; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ADIPOCYTE; BIOLOGICAL ACTIVITY; CELL DIFFERENTIATION; CONFERENCE PAPER; DRUG RECEPTOR BINDING; FIBROBLAST; HUMAN; INFLAMMATION; LIPID METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PAIN; RECEPTOR AFFINITY; TREATMENT INDICATION; VASODILATATION;

AZO COMPOUNDS; DIABETES MELLITUS, TYPE 2; LIGANDS; LIPID METABOLISM; PPAR GAMMA; RECEPTORS, CANNABINOID; TETRAHYDROCANNABINOL; THIAZOLIDINEDIONES; TRANS-ACTIVATION (GENETICS);

RODENTIA;

EID: 23044475561     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.05.039     Document Type: Conference Paper

References (47)

1. D.S. Bell Beneficial effects resulting from thiazolidinediones for treatment of type 2 diabetes mellitus Postgraduate Medicine 2003 35 44
2. J. Berger, and D.E. Moller The mechanisms of action of PPARs Annual Review of Medicine 53 2002 409 435
3. M. Bhandari, and E.H. Schemitsch High-pressure irrigation increases adipocyte-like cells at the expense of osteoblasts in vitro Journal of Bone and Joint Surgery. British Volume 84 2002 1054 1061
4. A.E. Brodie, V.A. Manning, K.R. Ferguson, D.E. Jewell, and C.Y. Hu Conjugated linoleic acid inhibits differentiation of pre- and post-confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells Journal of Nutrition 129 1999 602 606
5. S.H. Burstein The cannabinoid acids: nonpsychoactive derivatives with therapeutic potential Pharmacology and Therapeutics 82 1999 87 96
6. G. Castillo, R.P. Brun, J.K. Rosenfield, S. Hauser, C.W. Park, A.E. Troy, M.E. Wright, and B.M. Spiegelman An adipogenic cofactor bound by the differentiation domain of PPARgamma EMBO Journal 18 1999 3676 3687
7. F.S. Celi, and A.R. Shuldiner The role of peroxisome proliferator- activated receptor gamma in diabetes and obesity Current Diabetes Report 2 2002 179 185
8. A. Chawla, J.J. Repa, R.M. Evans, and D.J. Mangelsdorf Nuclear receptors and lipid physiology: opening the X-files Science 294 2001 1866 1870
9. J.E. Cobb, S.G. Blanchard, E.G. Boswell, K.K. Brown, P.S. Charifson, J.P. Cooper, J.L. Collins, M. Dezube, B.R. Henke, E.A. Hull-Ryde, D.H. Lake, J.M. Lenhard, W. Oliver Jr., J. Oplinger, M. Pentti, D.J. Parks, K.D. Plunket, and W.Q. Tong N-(2-Benzoylphenyl)-l-tyrosine PPAR gamma agonists: 3. Structure-activity relationship and optimization of the N-aryl substituent Journal of Medicinal Chemistry 41 1998 5055 5069
10. D.D. Diascro Jr., R.L. Vogel, T.E. Johnson, K.M. Witherup, S.M. Pitzenberger, S.J. Rutledge, D.J. Prescott, G.A. Rodan, and A. Schmidt High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells Journal of Bone and Mineral Research 13 1998 96 106
11. V. Di Marzo, L. De Petrocellis, F. Fezza, A. Ligresti, and T. Bisogno Anandamide receptors Prostaglandins, Leukotrienes and Essential Fatty Acids 66 2002 377 391
12. F.M. Gregoire Adipocyte differentiation: from fibroblast to endocrine cell Experimental Biology and Medicine (Maywood) 226 2001 997 1002
13. J. Gros, C.C. Gerhardt, and A.D. Strosberg Expression of human (beta)3-adrenergic receptor induces adipocyte-like features in CHO/K1 fibroblasts Journal of Cell Science 112 Pt. 21 1999 3791 3797
14. M. Gurnell, D.B. Savage, V.K. Chatterjee, and S. O'Rahilly The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation Journal of Clinical Endocrinology and Metabolism 88 2003 2412 2421
15. S.A. Habinowski, and L.A. Witters The effects of AICAR on adipocyte differentiation of 3T3-L1 cells Biochemical and Biophysical Research Communications 286 2001 852 856
16. A.W. Harmon, Y.M. Patel, and J.B. Harp Genistein inhibits CCAAT/enhancer-binding protein beta (C/EBPbeta) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression Biochemical Journal 367 2002 203 208
17. H. Hauner The mode of action of thiazolidinediones Diabetes/Metabolism Research and Reviews 18 Suppl. 2 2002 S10 S15
18. S.M. Huang, T. Bisogno, T.J. Petros, S.Y. Chang, P.A. Zavitsanos, R.E. Zipkin, R. Sivakumar, A. Coop, D.Y. Maeda, L. De Petrocellis, S. Burstein, V. Di Marzo, and J.M. Walker Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain Journal of Biological Chemistry 276 2001 42639 42644
19. M. Karst, K. Salim, S. Burstein, I. Conrad, L. Hoy, and U. Schneider Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial JAMA 290 2003 1757 1762
20. H.S. Kim, L. Liang, R.G. Dean, D.B. Hausman, D.L. Hartzell, and C.A. Baile Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures Biochemical and Biophysical Research Communications 281 2001 902 906
21. T.M. Larsen, S. Toubro, and A. Astrup PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? International Journal of Obesity and Related Metabolic Disorders 27 2003 147 161
22. H.E. Lebovitz Differentiating members of the thiazolidinedione class: a focus on safety Diabetes/Metabolism Research and Reviews 18 Suppl 2 2002 S23 S29
23. L.M. Leesnitzer, D.J. Parks, R.K. Bledsoe, J.E. Cobb, J.L. Collins, T.G. Consler, R.G. Davis, E.A. Hull-Ryde, J.M. Lenhard, L. Patel, K.D. Plunket, J.L. Shenk, J.B. Stimmel, C. Therapontos, T.M. Willson, and S.G. Blanchard Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662 Biochemistry 41 2002 6640 6650
24. J.M. Lenhard, E.S. Furfine, R.G. Jain, O. Ittoop, L.A. Orband-Miller, S.G. Blanchard, M.A. Paulik, and J.E. Weiel HIV protease inhibitors block adipogenesis and increase lipolysis in vitro Antiviral Research 47 2000 121 129
25. K.L. Levert, G.L. Waldrop, and J.M. Stephens A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis Journal of Biological Chemistry 277 2002 16347 16350
26. J. Liu, H. Li, S.H. Burstein, R.B. Zurier, and J.D. Chen Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid Molecular Pharmacology 63 2003 983 992
27. D.E. Moller New drug targets for type 2 diabetes and the metabolic syndrome Nature 414 2001 821 827
28. R. Mukherjee, P.A. Hoener, L. Jow, J. Bilakovics, K. Klausing, D.E. Mais, A. Faulkner, G.E. Croston, and J.R. Paterniti Jr. A selective peroxisome proliferator-activated receptor-gamma (PPARgamma) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes Molecular Endocrinology 14 2000 1425 1433
29. R. Okazaki, M. Toriumi, S. Fukumoto, M. Miyamoto, T. Fujita, K. Tanaka, and Y. Takeuchi Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro Endocrinology 140 1999 5060 5065
30. C. Otto, M. Lehrke, and B. Goke Novel insulin sensitizers: pharmacogenomic aspects Pharmacogenomics 3 2002 99 116
31. R.G. Pertwee Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors Life Sciences 65 1999 597 605
32. R.G. Pertwee Cannabinoids and the gastrointestinal tract Gut 48 2001 859 867
33. R.G. Pertwee, and R.A. Ross Cannabinoid receptors and their ligands Prostaglandins, Leukotrienes and Essential Fatty Acids 66 2002 101 121
34. A. Raji, and J. Plutzky Insulin resistance, diabetes, and atherosclerosis: thiazolidinediones as therapeutic interventions Current Cardiology Reports 4 2002 514 521
35. L.D. Recht, R. Salmonsen, R. Rosetti, T. Jang, G. Pipia, T. Kubiatowski, P. Karim, A.H. Ross, R. Zurier, N.S. Litofsky, and S. Burstein Antitumor effects of ajulemic acid (CT3), a synthetic non-psychoactive cannabinoid Biochemical Pharmacology 62 2001 755 763
36. M. Rivier, I. Castiel, I. Safonova, G. Ailhaud, and S. Michel Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model Journal of Investigative Dermatology 114 2000 681 687
37. C. Rockwell, and N. Kaminski Inhibition of IL-2 production by 2-AG is partially mediated by PPAR-gamma R. Musty 2003 Symposium on the Cannabinoids 2003 International Cannabinoid Research Society Burlington, VT 32
38. B.G. Shearer, and W.J. Hoekstra Recent advances in peroxisome proliferator-activated receptor science Current Medicinal Chemistry 10 2003 267 280
39. X.M. Shi, H.C. Blair, X. Yang, J.M. McDonald, and X. Cao Tandem repeat of C/EBP binding sites mediates PPARgamma2 gene transcription in glucocorticoid-induced adipocyte differentiation Journal of Cellular Biochemistry 76 2000 518 527
40. K. Starkey, A. Heufelder, G. Baker, W. Joba, M. Evans, S. Davies, and M. Ludgate Peroxisome proliferator-activated receptor-gamma in thyroid eye disease: contraindication for thiazolidinedione use? Journal of Clinical Endocrinology and Metabolism 88 2003 55 59
41. M. Stumvoll Thiazolidinediones-some recent developments Expert Opinion on Investigational Drugs 12 2003 1179 1187
42. Q.Q. Tang, T.C. Otto, and M.D. Lane CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis Proceedings of the National Academy of Sciences of the United States of America 100 2003 850 855
43. Y.D. Tchoukalova, D.B. Hausman, R.G. Dean, and G.J. Hausman Enhancing effect of troglitazone on porcine adipocyte differentiation in primary culture: a comparison with dexamethasone Obesity Research 8 2000 664 672
44. L. Van Gaal, and A.J. Scheen Are all glitazones the same? Diabetes/Metabolism Research and Reviews 18 Suppl. 2 2002 S1 S4
45. B.K. Zehentner, U. Leser, and H. Burtscher BMP-2 and sonic hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1/2 cells DNA and Cell Biology 19 2000 275 281
46. R.B. Zurier, R.G. Rossetti, S.H. Burstein, and B. Bidinger Suppression of human monocyte interleukin-1beta production by ajulemic acid, a nonpsychoactive cannabinoid Biochemical Pharmacology 65 2003 649 655
47. P.M. Zygmunt, J. Petersson, D.A. Andersson, H. Chuang, M. Sorgard, V. Di Marzo, D. Julius, and E.D. Hogestatt Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide Nature 400 1999 452 457