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Volumn 91, Issue 4, 2009, Pages 457-465

Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: Involvement of the transcription factor PPARγ

Author keywords

Apoptosis; Cannabinoids; Hepatoma cells; PPAR

Indexed keywords

ANILIDES; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZAMIDES; BENZOXAZINES; CANNABINOIDS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; LIVER NEOPLASMS; MEMBRANE MICRODOMAINS; MORPHOLINES; NAPHTHALENES; PPAR GAMMA; PROTEIN KINASES; PYRIDINES; RECEPTOR, CANNABINOID, CB2; SIGNAL TRANSDUCTION;

EID: 62649170623     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2008.11.003     Document Type: Article
Times cited : (64)

References (40)
  • 1
    • 0034087404 scopus 로고    scopus 로고
    • Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report
    • Watson S.J., Benson Jr. J.A., and Joy J.E. Marijuana and medicine: assessing the science base: a summary of the 1999 Institute of Medicine report. Arch. Gen. Psychiatry 57 (2000) 547-552
    • (2000) Arch. Gen. Psychiatry , vol.57 , pp. 547-552
    • Watson, S.J.1    Benson Jr., J.A.2    Joy, J.E.3
  • 2
    • 0033921628 scopus 로고    scopus 로고
    • Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development
    • Pertwee R.G. Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development. Expert. Opin. Invest. Drugs 9 (2000) 1553-1571
    • (2000) Expert. Opin. Invest. Drugs , vol.9 , pp. 1553-1571
    • Pertwee, R.G.1
  • 3
    • 0034929449 scopus 로고    scopus 로고
    • The endocannabinoid nervous system: unique opportunities for therapeutic intervention
    • Porter A.C., and Felder C.C. The endocannabinoid nervous system: unique opportunities for therapeutic intervention. Pharmacol. Ther 90 (2001) 45-60
    • (2001) Pharmacol. Ther , vol.90 , pp. 45-60
    • Porter, A.C.1    Felder, C.C.2
  • 5
    • 24644450190 scopus 로고    scopus 로고
    • Cannabinoid receptors and their role in neuroprotection
    • van der Stelt M., and Di Marzo V. Cannabinoid receptors and their role in neuroprotection. Neuromol. Med 7 (2005) 37-50
    • (2005) Neuromol. Med , vol.7 , pp. 37-50
    • van der Stelt, M.1    Di Marzo, V.2
  • 6
    • 35748964430 scopus 로고    scopus 로고
    • Modulation of the endocannabinoid system by lipid rafts
    • Dainese E., Oddi S., Bari M., and Maccarrone M. Modulation of the endocannabinoid system by lipid rafts. Curr. Med. Chem. 14 (2007) 2702-2715
    • (2007) Curr. Med. Chem. , vol.14 , pp. 2702-2715
    • Dainese, E.1    Oddi, S.2    Bari, M.3    Maccarrone, M.4
  • 8
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
    • Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., and Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci 11 (1991) 563-583
    • (1991) J. Neurosci , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    de Costa, B.R.5    Rice, K.C.6
  • 9
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: potential anticancer agents
    • Guzman M. Cannabinoids: potential anticancer agents. Nat Rev Cancer 3 (2003) 745-755
    • (2003) Nat Rev Cancer , vol.3 , pp. 745-755
    • Guzman, M.1
  • 10
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • Sarfaraz S., Afaq F., Adhami V.M., and Mukhtar H. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res. 65 (2005) 1635-1641
    • (2005) Cancer Res. , vol.65 , pp. 1635-1641
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 13
    • 33845973763 scopus 로고    scopus 로고
    • Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest
    • Sarfaraz S., Afaq F., Adhami V.M., Malik A., and Mukhtar H. Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. J. Biol. Chem. 281 (2006) 39480-39491
    • (2006) J. Biol. Chem. , vol.281 , pp. 39480-39491
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Malik, A.4    Mukhtar, H.5
  • 14
    • 33751198532 scopus 로고    scopus 로고
    • Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
    • Gustafsson K., Christensson B., Sander B., and Flygare J. Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma. Mol. Pharmacol 70 (2006) 1612-1620
    • (2006) Mol. Pharmacol , vol.70 , pp. 1612-1620
    • Gustafsson, K.1    Christensson, B.2    Sander, B.3    Flygare, J.4
  • 16
    • 0031724645 scopus 로고    scopus 로고
    • Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes
    • Sánchez C., Galve-Roperh I., Rueda D., and Guzmán M. Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes. Mol. Pharmacol 54 (1998) 834-843
    • (1998) Mol. Pharmacol , vol.54 , pp. 834-843
    • Sánchez, C.1    Galve-Roperh, I.2    Rueda, D.3    Guzmán, M.4
  • 17
    • 17344380844 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
    • Galve-Roperh I., Sánchez C., Cortés M.L., Gómez del Pulgar T., Izquierdo M., and Guzmán M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nature Med 6 (2000) 313-319
    • (2000) Nature Med , vol.6 , pp. 313-319
    • Galve-Roperh, I.1    Sánchez, C.2    Cortés, M.L.3    Gómez del Pulgar, T.4    Izquierdo, M.5    Guzmán, M.6
  • 18
    • 28944453205 scopus 로고    scopus 로고
    • Cannabinoid signalling
    • Demuth D.G., and Molleman A. Cannabinoid signalling. Life Sci. 78 (2006) 549-563
    • (2006) Life Sci. , vol.78 , pp. 549-563
    • Demuth, D.G.1    Molleman, A.2
  • 19
    • 33645842782 scopus 로고    scopus 로고
    • Cannabinoid agonist WIN55,212-2 induces apoptosis in cerebellar granule cells via activation of the CB1 receptor and downregulation of bcl-xL gene expression
    • Pozzoli G., Tringali G., Vairano M., D'Amico M., Navarra P., and Martire M. Cannabinoid agonist WIN55,212-2 induces apoptosis in cerebellar granule cells via activation of the CB1 receptor and downregulation of bcl-xL gene expression. J. Neurosci. Res. 83 (2006) 1058-1065
    • (2006) J. Neurosci. Res. , vol.83 , pp. 1058-1065
    • Pozzoli, G.1    Tringali, G.2    Vairano, M.3    D'Amico, M.4    Navarra, P.5    Martire, M.6
  • 20
    • 35649008926 scopus 로고    scopus 로고
    • Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors
    • O'Sullivan S.E. Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors. Br. J. Pharmacol 152 (2007) 576-582
    • (2007) Br. J. Pharmacol , vol.152 , pp. 576-582
    • O'Sullivan, S.E.1
  • 21
    • 14544303179 scopus 로고    scopus 로고
    • PPAR gamma 10 years later
    • Lazar M.A. PPAR gamma 10 years later. Biochimie 87 (2005) 9-13
    • (2005) Biochimie , vol.87 , pp. 9-13
    • Lazar, M.A.1
  • 22
    • 35448982383 scopus 로고    scopus 로고
    • Biology of PPAR gamma in cancer: a critical review on existing lacunae
    • Krishnan A., Nair S.A., and Pillai M.R. Biology of PPAR gamma in cancer: a critical review on existing lacunae. Curr. Mol. Med 7 (2007) 532-540
    • (2007) Curr. Mol. Med , vol.7 , pp. 532-540
    • Krishnan, A.1    Nair, S.A.2    Pillai, M.R.3
  • 23
    • 22144477527 scopus 로고    scopus 로고
    • Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation
    • Bouaboula M., Hilairet S., Marchand J., Fajas L., Le Fur G., and Casellas P. Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. Eur. J. Pharmacol 517 (2005) 174-181
    • (2005) Eur. J. Pharmacol , vol.517 , pp. 174-181
    • Bouaboula, M.1    Hilairet, S.2    Marchand, J.3    Fajas, L.4    Le Fur, G.5    Casellas, P.6
  • 24
    • 23044475561 scopus 로고    scopus 로고
    • PPAR-gamma: a nuclear receptor with affinity for cannabinoids
    • Burstein S. PPAR-gamma: a nuclear receptor with affinity for cannabinoids. Life Sci. 77 (2005) 1674-1684
    • (2005) Life Sci. , vol.77 , pp. 1674-1684
    • Burstein, S.1
  • 25
    • 34547107881 scopus 로고    scopus 로고
    • Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma
    • Ambrosio A.L., Dias S.M., Polikarpov I., Zurier R.B., Burstein S.H., and Garratt R.C. Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 282 (2007) 18625-18633
    • (2007) J. Biol. Chem. , vol.282 , pp. 18625-18633
    • Ambrosio, A.L.1    Dias, S.M.2    Polikarpov, I.3    Zurier, R.B.4    Burstein, S.H.5    Garratt, R.C.6
  • 27
    • 2942605897 scopus 로고    scopus 로고
    • Sodium butyrate induces apoptosis in human hepatoma cells by a mitochondria/ caspase pathway, associated with degradation of beta-catenin, pRb and Bcl-XL
    • Emanuele S., D'Anneo A., Bellavia G., Vassallo B., Lauricella M., De Blasio A., Vento R., and Tesoriere G. Sodium butyrate induces apoptosis in human hepatoma cells by a mitochondria/ caspase pathway, associated with degradation of beta-catenin, pRb and Bcl-XL. Eur. J. Cancer 40 (2004) 1441-1452
    • (2004) Eur. J. Cancer , vol.40 , pp. 1441-1452
    • Emanuele, S.1    D'Anneo, A.2    Bellavia, G.3    Vassallo, B.4    Lauricella, M.5    De Blasio, A.6    Vento, R.7    Tesoriere, G.8
  • 30
    • 34548533382 scopus 로고    scopus 로고
    • Hsp72 controls bortezomib-induced HepG2 cell death via interaction with pro-apoptotic factors
    • Calvaruso G., Giuliano M., Portanova P., Pellerito O., Vento R., and Tesoriere G. Hsp72 controls bortezomib-induced HepG2 cell death via interaction with pro-apoptotic factors. Oncol. Rep 18 (2007) 447-450
    • (2007) Oncol. Rep , vol.18 , pp. 447-450
    • Calvaruso, G.1    Giuliano, M.2    Portanova, P.3    Pellerito, O.4    Vento, R.5    Tesoriere, G.6
  • 32
    • 39549117156 scopus 로고    scopus 로고
    • Denbinobin induces apoptosis in human lung adenocarcinoma cells via AKT inactivation, Bad activation, and mitochondrial dysfunction
    • Kuo C.T., Hsu M.J., Chen B.C., Chen C.C., Teng C.M., Pan S.L., and Lin C.H. Denbinobin induces apoptosis in human lung adenocarcinoma cells via AKT inactivation, Bad activation, and mitochondrial dysfunction. Toxicol. Lett. 177 (2008) 48-58
    • (2008) Toxicol. Lett. , vol.177 , pp. 48-58
    • Kuo, C.T.1    Hsu, M.J.2    Chen, B.C.3    Chen, C.C.4    Teng, C.M.5    Pan, S.L.6    Lin, C.H.7
  • 33
    • 43549088782 scopus 로고    scopus 로고
    • Resveratrol: a multitargeted agent for age-associated chronic diseases
    • Harikumar K.B., and Aggarwal B.B. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 7 (2008) 1020-1035
    • (2008) Cell Cycle , vol.7 , pp. 1020-1035
    • Harikumar, K.B.1    Aggarwal, B.B.2
  • 35
    • 33845810433 scopus 로고    scopus 로고
    • Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade
    • Reddy R.M., Yeow W.S., Chua A., Nguyen D.M., Baras A., Ziauddin M.F., Shamimi-Noori S.M., Maxhimer J.B., Schrump D.S., and Nguyen D.M. Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. Apoptosis 12 (2007) 55-71
    • (2007) Apoptosis , vol.12 , pp. 55-71
    • Reddy, R.M.1    Yeow, W.S.2    Chua, A.3    Nguyen, D.M.4    Baras, A.5    Ziauddin, M.F.6    Shamimi-Noori, S.M.7    Maxhimer, J.B.8    Schrump, D.S.9    Nguyen, D.M.10
  • 36
    • 40849084900 scopus 로고    scopus 로고
    • Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors
    • C
    • Accorsi-Mendonça D., Almado C.E., Dagostin A.L., Machado B.H., and Leão R.M. Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors. Brain Res. 1200 (2008) 1-9 C
    • (2008) Brain Res. , vol.1200 , pp. 1-9
    • Accorsi-Mendonça, D.1    Almado, C.E.2    Dagostin, A.L.3    Machado, B.H.4    Leão, R.M.5
  • 37
    • 33746716146 scopus 로고    scopus 로고
    • Differential anti-proliferative actions of peroxisome proliferator-activated receptor-gamma agonists in MCF-7 breast cancer cells
    • Kim K.Y., Kim S.S., and Cheon H.G. Differential anti-proliferative actions of peroxisome proliferator-activated receptor-gamma agonists in MCF-7 breast cancer cells. Biochem. Pharmacol 72 (2006) 530-540
    • (2006) Biochem. Pharmacol , vol.72 , pp. 530-540
    • Kim, K.Y.1    Kim, S.S.2    Cheon, H.G.3
  • 38
    • 33845711007 scopus 로고    scopus 로고
    • PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells
    • Schaefer K.L., Takahashi H., Morales V.M., Harris G., Barton S., Osawa E., Nakajima A., and Saubermann L.J. PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells. Int. J. Cancer 120 (2007) 702-713
    • (2007) Int. J. Cancer , vol.120 , pp. 702-713
    • Schaefer, K.L.1    Takahashi, H.2    Morales, V.M.3    Harris, G.4    Barton, S.5    Osawa, E.6    Nakajima, A.7    Saubermann, L.J.8
  • 39
    • 14544272384 scopus 로고    scopus 로고
    • Phosphorylation of PPARs: from molecular characterization to physiological relevance
    • Diradourian C., Girard J., and Pégorier J.P. Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochimie 87 (2005) 33-38
    • (2005) Biochimie , vol.87 , pp. 33-38
    • Diradourian, C.1    Girard, J.2    Pégorier, J.P.3


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