Transdermal delivery of insulin using trypsin as a biochemical enhancer

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 8, 2008, Pages 1574-1579

  Li, Ying Zhe ^a   Quan, Ying Shu ^b,c   Zang, Lei ^b   Jin, Mei Na ^b   Kamiyama, Fumio ^c   Katsumi, Hidemasa ^b   Yamamoto, Akira ^b   Tsutsumi, Sadami ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c CosMED Pharmaceutical Co Ltd ^*  (Japan)

Author keywords

Biochemical enhancer; Insulin; Plasma glucose level; Transdermal; Trypsin

Indexed keywords

BOVINE INSULIN; TRYPSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; ELECTRIC RESISTANCE; GLUCOSE BLOOD LEVEL; HISTOLOGY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MALE; NONHUMAN; RAT; SKIN PERMEABILITY; STATISTICAL ANALYSIS; STREPTOZOCIN DIABETES;

ADMINISTRATION, CUTANEOUS; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; EXCIPIENTS; GALVANIC SKIN RESPONSE; HYPOGLYCEMIC AGENTS; INSULIN; MALE; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TRYPSIN;

EID: 48849086552     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1574     Document Type: Article

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