Transdermal iontophoresis of insulin: VI. Influence of pretreatment with fatty acids on permeation across rat skin

Skin Pharmacology and Physiology

Volumn 17, Issue 6, 2004, Pages 289-297

  Pillai, O ^a   Panchagnula, R ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Fatty acid uptake; Fatty acid ethanol; Grain boundaries; Lipid extraction

Indexed keywords

FATTY ACID; INSULIN; LAURIC ACID; LINOLEIC ACID; LINOLENIC ACID; OLEIC ACID; SATURATED FATTY ACID; SKIN LIPID; UNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG PENETRATION; FEMALE; INFRARED RADIATION; IONTOPHORESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY;

ANIMALS; ETHANOL; FATTY ACIDS; FEMALE; HYPOGLYCEMIC AGENTS; INSULIN; IONTOPHORESIS; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 8344232743     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081114     Document Type: Article

References (37)

1. Naik A, Kalia YN, Guy RH: Transdermal drug delivery: Overcoming the skin's barrier function. Pharm Sci Technol Today 2000;3:318-326.
2. Barry BW: Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 2001;14:101-114.
3. Banga AK, Chien YW: Iontophoretic delivery of drugs: Fundamentals, developments and biomedical applications. J Control Release 1988;7:1-24.
4. Pillai O, Nair V, Poduri R, Panchagnula R: Transdermal iontophoresis. II. Peptide and protein delivery. Methods Find Exp Clin Pharmacol 1999;21:229-240.
5. Bhatia KS, Singh J: Synergistic effect of iontophoresis and a series of fatty acids on LHRH permeability through porcine skin. J Pharm Sci 1998;87:462-469.
6. Pillai O, Nair V, Jain AK, Thomas NS, Panchagnula R: Noninvasive transdermal delivery of peptides and proteins. Drugs Fut 2001;26:779-791.
7. Pillai O, Nair V, Panchagnula R: Transdermal iontophoresis. IV. Influence of chemical enhancers. Int J Pharm 2004;269:109-120.
8. Pillai O, Panchagnula R: Transdermal iontophoresis. V. Effect of terpenes J Control Release 2003;88:287-296.
9. Kanikkannan N, Kandimalla K, Lamba SS, Singh M: Structure-activity relationships of chemical penetration enhancers in transdermal drug delivery. Curr Med Chem 2000;7:593-608.
10. Klausner RD, Kleinfeld AM, Hoover RL, Karnowsky MJ: Lipid domains in membranes: Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity studies. J Biol Chem 1980;255:1286-1295.
11. Lu MF, Lee D, Rao GS: Percutaneous absorption enhancement of leuprolide. Pharm Res 1992;9:1575-1579.
12. Scott RC, Walker M, Dugard PH: In-vitro percutaneous absorption experiments: A technique for production of intact epidermal membranes from rat skin. J Soc Cosmet Chem 1986;37:35-41.
13. Sato S, Ebert CD, Kim SW: Prevention of insulin self-association and surface adsorption. J Pharm Sci 1983;72:228-232.
14. Bhatia KS, Singh J: Mechanism of transport enhancement of LHRH through porcine epidermis by terpene and iontophoresis permeability and lipid extraction studies. Pharm Res 1998;15:2069-2087.
15. Tanojo H, Junginger H, Bodde HE: In vivo skin permeability enhancement by oleic acid: Transepidermal water loss and Fourier-transform infrared spectroscopy studies. J Control Release 1997;47:31-39.
16. Ritschel WA, Starzacher A, Sabouni A, Hussain AS, Kock P: Percutaneous absorption of rosmarinic acid in the rat. Methods Find Exp Clin Pharmacol 1989;11:345-352.
17. Panchagnula R, Patel J: Transdermal delivery of azidothymidine (AZT) through rat skin: Ex-vivo. Pharm Sci 1997;3:83-87.
18. Suhonen TM, Bouwstra JA, Urtti A: Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations. J Control Release 1999;59:149-161.
19. Ogiso T, Shintani M: Mechanism for the enhancement effect of fatty acids on the percutaneous absorption of propranolol. J Pharm Sci 1990;79:1065-1071.
20. Kim CK, Kim JJ, Chi SC, Shim CK: Effect of fatty acids and urea on the penetration of ketoprofen through rat skin. Int J Pharm 1993;99:109-118.
21. Kandimalla K, Kanikkannan N, Andega S, Singh M: Effect of fatty acids on the permeation of melatonin across rat and pigskin in vitro and on the transepidermal water loss in rats. J Pharm Pharmacol 1999;51:783-790.
22. Pilgram G: A Close Look at the Stratum corneum Lipid Organization by Cryo-Electron Diffraction: Significance for the Barrier Function of Human Skin; PhD thesis, Center for Drug Research, Leiden University, Leiden, 2000.
23. Hinsberg WHMC, Verhoef JC, Spies F, Bouwstra JA, Gooris GS, Junginger HE, Bodde HE: Electroperturbation of the human skin barrier in vitro. II. Effects on stratum corneum lipid ordering and ultra structure. Microsc Res Tech 1997;37:200-213.
24. Brain KR, Walters KA: Molecular modeling of skin permeation enhancement by chemical agents; in Walters KA, Hadgraft J (eds): Pharmaceutical Skin Penetration Enhancement. New York, Dekker, 1993, pp 365-388.
25. Golden GM, McKie JA, Potts RO: Role of stratum corneum lipid fluidity in transdermal drug flux. J Pharm Sci 1987;76:25-28.
26. Gay CL, Murphy TM, Hadgraft J, Kellaway IW, Evans JC, Rowlands CC: An electron spin resonance study of skin penetration enhancers. Int J Pharm 1989;49:39-45.
27. Francouer ML, Golden GM, Potts RO: Oleic acid, its effects on stratum corneum in relation to (trans)dermal drug delivery. Pharm Res 1990;7:621-627.
28. Ongpipattanakul B, Burnette RR, Potts RO, Francoeur ML: Evidence that oleic acid exists in a separate phase within stratum corneum lipids. Pharm Res 1991;8:350-354.
29. Walker M, Hadgraft J: Oleic acid - A membrane 'fluidiser' or fluid within the membrane. Int J Pharm 1991;71:R1-R4.
30. Garrison MD, Doh LM, Potts RO, Abraham W: Effect of oleic acid on human epidermis: Fluorescence spectroscopic investigation. J Control Release 1994;31:263-269.
31. Oh SY, Jeong SY, Park TG, Lee JH: Enhanced transdermal delivery of AZT (zidovudine) using iontophoresis and penetration enhancer. J Control Release 1998;51:161-168.
32. Tanojo H, Bouwstra JA, Junginger H, Bodde HE: In vitro human skin barrier modulation by fatty acids: Skin permeation and thermal analysis studies. Pharm Res 1997;14:42-49.
33. Mak VHW, Potts RO, Guy RH: Oleic acid concentration and effect in human stratum corneum: Non-invasive determination by attenuated total reflectance infrared spectroscopy in vivo. J Control Release 1990;12:299-306.
34. Elias PM, Mak V, Thornfeldt C, Feingold KR: Interference with stratum corneum lipid biogenesis; in Bronaugh RL, Maibach HI, (eds): Percutaneous Absorption: Drugs - Cosmetics - Mechanisms - Methodology, ed 3. New York, Dekker, 1999, pp 411-425.
35. Jain AK, Panchagnula R: Effect of temperature on imipramine hydrochloride permeation: Role of lipid bilayer arrangement and chemical composition of rat skin. Int J Pharm 2003;250:287-293.
36. Kanikkannan N, Singh J, Ramarao P: In vitro transdermal iontophoretic transport of timolol maleate: Effect of age and species. J Control Release 2001;71:99-105.
37. Stagni G, Ali ME, Weng D: Pharmacokinetics of acyclovir in rabbit skin after iv-bolus, ointment and iontophoretic administrations. Int J Pharm 2004;274:201-211.