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Volumn 97, Issue 1, 2004, Pages 55-66

Synergistic penetration enhancement effect of ethanol and phospholipids on the topical delivery of cyclosporin a

Author keywords

CLSM; confocal laser scanning microscopy; CyA; Cyclosporin A; cyclosporin A; DLS; Ethanol; Liposome; PBS; phosphate buffer saline, pH 7.4; Phosphatidylcholine; PI; polydispersity index; SC; Skin penetration; stratum corneum; TEM; transmission electron microscopy

Indexed keywords

DEPOSITION; DIFFUSION; DISEASES; MIXTURES; PHOSPHOLIPIDS; SKIN;

EID: 2442604323     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.02.028     Document Type: Article
Times cited : (155)

References (45)
  • 1
    • 0020961534 scopus 로고
    • Influence of vehicles on penetration through human epidermis of benzyl alcohol, isoeugenol and methyl isoeugenol
    • Jimbo Y., Ishihara M., Osamura H., Takano M., Ohara M. Influence of vehicles on penetration through human epidermis of benzyl alcohol, isoeugenol and methyl isoeugenol. J. Dermatol. 10:1983;241-250
    • (1983) J. Dermatol. , vol.10 , pp. 241-250
    • Jimbo, Y.1    Ishihara, M.2    Osamura, H.3    Takano, M.4    Ohara, M.5
  • 2
    • 0032759792 scopus 로고    scopus 로고
    • Synthesis and evaluation of N-acetylprolinate esters - Novel skin penetration enhancers
    • Tenjarla S.N., Kasina R., Puranajoti P., Omar M.S., Harris W.T. Synthesis and evaluation of N-acetylprolinate esters - novel skin penetration enhancers. Int. J. Pharm. 192:1999;147-158
    • (1999) Int. J. Pharm. , vol.192 , pp. 147-158
    • Tenjarla, S.N.1    Kasina, R.2    Puranajoti, P.3    Omar, M.S.4    Harris, W.T.5
  • 3
    • 0024351662 scopus 로고
    • Effect of choline esters and oleic acid on the penetration of acyclovir, estradiol, hydrocortisone, nitroglycerin, retinoic acid and trifluorothymidine across hairless mouse skin in-vitro
    • Loftsson T., Somogyi G., Bodor N. Effect of choline esters and oleic acid on the penetration of acyclovir, estradiol, hydrocortisone, nitroglycerin, retinoic acid and trifluorothymidine across hairless mouse skin in-vitro. Acta Pharm. Nord. 1:1989;279-286
    • (1989) Acta Pharm. Nord. , vol.1 , pp. 279-286
    • Loftsson, T.1    Somogyi, G.2    Bodor, N.3
  • 4
    • 0019958118 scopus 로고
    • Liposomes-a selective drug delivery system for the topical route of administration: Gel dosage form
    • Mezei M., Gulasekharam V. Liposomes-a selective drug delivery system for the topical route of administration: gel dosage form. J. Pharm. Pharmacol. 34:1982;473-474
    • (1982) J. Pharm. Pharmacol. , vol.34 , pp. 473-474
    • Mezei, M.1    Gulasekharam, V.2
  • 5
    • 0019309326 scopus 로고
    • Liposomes-a selective drug delivery system for the topical route of administration. Lotion dosage form
    • Mezei M., Gulasekharam V. Liposomes-a selective drug delivery system for the topical route of administration. Lotion dosage form. Life Sci. 26:1980;1473-1477
    • (1980) Life Sci. , vol.26 , pp. 1473-1477
    • Mezei, M.1    Gulasekharam, V.2
  • 7
    • 0025114527 scopus 로고
    • Liposome encapsulation improves efficacy of betamethasone dipropionate in atopic eczema but not in psoriasis vulgaris
    • Korting H.C., Zienicke H., Schafer-Korting M., Braun-Falco O. Liposome encapsulation improves efficacy of betamethasone dipropionate in atopic eczema but not in psoriasis vulgaris. Eur. J. Clin. Pharmacol. 29:1991;349
    • (1991) Eur. J. Clin. Pharmacol. , vol.29 , pp. 349
    • Korting, H.C.1    Zienicke, H.2    Schafer-Korting, M.3    Braun-Falco, O.4
  • 8
    • 0026672778 scopus 로고
    • Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier, and prolongation of local pain insensitivity by anesthetic liposomes
    • Planas M.E., Gonzalez P., Rodriguez L., Sanchez S., Cevc G. Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier, and prolongation of local pain insensitivity by anesthetic liposomes. Anesth. Analg. 75:1992;615-621
    • (1992) Anesth. Analg. , vol.75 , pp. 615-621
    • Planas, M.E.1    Gonzalez, P.2    Rodriguez, L.3    Sanchez, S.4    Cevc, G.5
  • 9
    • 0023797362 scopus 로고
    • Topical anesthesia of the skin by liposome-encapsulated tetracaine
    • Gesztes A., Mezei M. Topical anesthesia of the skin by liposome-encapsulated tetracaine. Anesth. Analg. 67:1988;1079-1081
    • (1988) Anesth. Analg. , vol.67 , pp. 1079-1081
    • Gesztes, A.1    Mezei, M.2
  • 10
    • 0002649931 scopus 로고
    • Topical delivery with liposomes
    • Imbert D., Wickett R.R. Topical delivery with liposomes. Cosmet. Toilet. 110:1995;32-46
    • (1995) Cosmet. Toilet. , vol.110 , pp. 32-46
    • Imbert, D.1    Wickett, R.R.2
  • 11
    • 0032545780 scopus 로고    scopus 로고
    • Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin
    • Cevc G., Gebauer D., Stieber J., Schatzlein A., Blume G. Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim. Biophys. Acta. 1368:1998;201-215
    • (1998) Biochim. Biophys. Acta , vol.1368 , pp. 201-215
    • Cevc, G.1    Gebauer, D.2    Stieber, J.3    Schatzlein, A.4    Blume, G.5
  • 12
    • 0032934877 scopus 로고    scopus 로고
    • Effect of linolenic acid/ethanol or limonene/ethanol and iontophoresis on the in-vitro percutaneous absorption of LHRH and ultrastructure of human epidermis
    • Bhatia K.S., Singh J. Effect of linolenic acid/ethanol or limonene/ethanol and iontophoresis on the in-vitro percutaneous absorption of LHRH and ultrastructure of human epidermis. Int. J. Pharm. 180:1999;235-250
    • (1999) Int. J. Pharm. , vol.180 , pp. 235-250
    • Bhatia, K.S.1    Singh, J.2
  • 13
    • 0027972454 scopus 로고
    • Analysis of the combined effect of 1-menthol and ethanol as skin permeation enhancers based on a two-layer skin model
    • Kobayashi D., Matsuzawa T., Sugibayashi K., Morimoto Y., Kimura M. Analysis of the combined effect of 1-menthol and ethanol as skin permeation enhancers based on a two-layer skin model. Pharm. Res. 11:1994;96-103
    • (1994) Pharm. Res. , vol.11 , pp. 96-103
    • Kobayashi, D.1    Matsuzawa, T.2    Sugibayashi, K.3    Morimoto, Y.4    Kimura, M.5
  • 14
    • 0025346716 scopus 로고
    • Iontophoresis of polypeptides: Effect of ethanol pretreatment of human skin
    • Srinivasan V., Su M.H., Higuchi W.I., Behl C.R. Iontophoresis of polypeptides: effect of ethanol pretreatment of human skin. J. Pharm. Sci. 79:1990;588-591
    • (1990) J. Pharm. Sci. , vol.79 , pp. 588-591
    • Srinivasan, V.1    Su, M.H.2    Higuchi, W.I.3    Behl, C.R.4
  • 15
    • 0034119958 scopus 로고    scopus 로고
    • Carriers for skin delivery of trihexyphenidyl HCl: Ethosomes vs. liposomes
    • Dayan N., Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes. Biomaterials. 21:2000;1879-1885
    • (2000) Biomaterials , vol.21 , pp. 1879-1885
    • Dayan, N.1    Touitou, E.2
  • 17
    • 0033831489 scopus 로고    scopus 로고
    • Impact of absorption profiling on efficacy and safety of cyclosporin therapy in transplant recipients
    • Belitsky P., Dunn S., Johnston A., Levy G. Impact of absorption profiling on efficacy and safety of cyclosporin therapy in transplant recipients. Clin. Pharmacokinet. 39:2000;117-125
    • (2000) Clin. Pharmacokinet. , vol.39 , pp. 117-125
    • Belitsky, P.1    Dunn, S.2    Johnston, A.3    Levy, G.4
  • 18
    • 0029017526 scopus 로고
    • Percutaneous absorption and dermal delivery of cyclosporin a
    • Choi H.K., Flynn G.L., Amidon G.L. Percutaneous absorption and dermal delivery of cyclosporin A. J. Pharm. Sci. 84:1995;581-583
    • (1995) J. Pharm. Sci. , vol.84 , pp. 581-583
    • Choi, H.K.1    Flynn, G.L.2    Amidon, G.L.3
  • 19
    • 0028833229 scopus 로고
    • Natural alpha interferon in chronic actinic dermatitis. Report of a case
    • Parodi A., Gallo R., Guarrera M., Rebora A. Natural alpha interferon in chronic actinic dermatitis. Report of a case. Acta Derm.-Venereol. 75:1995;80
    • (1995) Acta Derm.-Venereol. , vol.75 , pp. 80
    • Parodi, A.1    Gallo, R.2    Guarrera, M.3    Rebora, A.4
  • 23
    • 0015927357 scopus 로고
    • Single bilayer liposomes prepared without sonication
    • Shmuel B., Edward D.K. Single bilayer liposomes prepared without sonication. Biochim. Biophys. Acta. 298:1973;1015-1019
    • (1973) Biochim. Biophys. Acta , vol.298 , pp. 1015-1019
    • Shmuel, B.1    Edward, D.K.2
  • 25
    • 0001035707 scopus 로고    scopus 로고
    • An ex vivo model for the study of drug penetration into human skin
    • Schaefer H., Loth H. An ex vivo model for the study of drug penetration into human skin. Pharm. Res. 13:1996;366
    • (1996) Pharm. Res. , vol.13 , pp. 366
    • Schaefer, H.1    Loth, H.2
  • 27
    • 0022976340 scopus 로고
    • Methods for in-vitro percutaneous absorption studies: VII. Use of excised human skin
    • Bronaugh R.L., Stewart R.F., Simon M. Methods for in-vitro percutaneous absorption studies: VII. Use of excised human skin. J. Pharm. Sci. 75:1986;1094-1097
    • (1986) J. Pharm. Sci. , vol.75 , pp. 1094-1097
    • Bronaugh, R.L.1    Stewart, R.F.2    Simon, M.3
  • 28
    • 0038061619 scopus 로고    scopus 로고
    • Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: A skin penetration and confocal laser scanning microscopy study
    • Verma D.D., Verma S., Blume G., Fahr A. Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: a skin penetration and confocal laser scanning microscopy study. Eur. J. Pharm. Biopharm. 55:2003;271-277
    • (2003) Eur. J. Pharm. Biopharm. , vol.55 , pp. 271-277
    • Verma, D.D.1    Verma, S.2    Blume, G.3    Fahr, A.4
  • 29
    • 0038513872 scopus 로고    scopus 로고
    • Particle size of liposomes influences dermal delivery of substances into skin
    • Verma D.D., Verma S., Blume G., Fahr A. Particle size of liposomes influences dermal delivery of substances into skin. Int. J. Pharm. 258:2003;141-151
    • (2003) Int. J. Pharm. , vol.258 , pp. 141-151
    • Verma, D.D.1    Verma, S.2    Blume, G.3    Fahr, A.4
  • 30
    • 0026497717 scopus 로고
    • Ethanol effects on the stratum corneum lipid phase behavior
    • Krill S.L., Knutson K., Higuchi W.I. Ethanol effects on the stratum corneum lipid phase behavior. Biochim. Biophys. Acta. 1112:1992;273-280
    • (1992) Biochim. Biophys. Acta , vol.1112 , pp. 273-280
    • Krill, S.L.1    Knutson, K.2    Higuchi, W.I.3
  • 31
    • 0019480487 scopus 로고
    • Membrane-disordering action of ethanol: Variation with membrane cholesterol content and depth of the spin label probe
    • Chin J.H., Goldstein D.B. Membrane-disordering action of ethanol: variation with membrane cholesterol content and depth of the spin label probe. Mol. Pharmacol. 19:1981;425-431
    • (1981) Mol. Pharmacol. , vol.19 , pp. 425-431
    • Chin, J.H.1    Goldstein, D.B.2
  • 32
    • 0033996247 scopus 로고    scopus 로고
    • Ethosomes - Novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties
    • Touitou E., Dayan N., Bergelson L., Godin B., Eliaz M. Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J. Control. Release. 65:2000;403-418
    • (2000) J. Control. Release , vol.65 , pp. 403-418
    • Touitou, E.1    Dayan, N.2    Bergelson, L.3    Godin, B.4    Eliaz, M.5
  • 33
    • 0024832063 scopus 로고
    • Ethanol: Water mutually enhanced transdermal therapeutic system: II. Skin permeation of ethanol and nitroglycerin
    • Berner B., Mazzenga G.C., Otte J.H., Steffens R.J., Juang R.H., Ebert C.D. Ethanol: water mutually enhanced transdermal therapeutic system: II. Skin permeation of ethanol and nitroglycerin. J. Pharm. Sci. 78:1989;402-407
    • (1989) J. Pharm. Sci. , vol.78 , pp. 402-407
    • Berner, B.1    Mazzenga, G.C.2    Otte, J.H.3    Steffens, R.J.4    Juang, R.H.5    Ebert, C.D.6
  • 34
    • 0023631403 scopus 로고
    • Delivery of theophylline into excised human skin from alkanoic acid solutions: A 'push-pull' mechanism
    • Kadir R., Stempler D., Liron Z., Cohen S. Delivery of theophylline into excised human skin from alkanoic acid solutions: a 'push-pull' mechanism. J. Pharm. Sci. 76:1987;774-779
    • (1987) J. Pharm. Sci. , vol.76 , pp. 774-779
    • Kadir, R.1    Stempler, D.2    Liron, Z.3    Cohen, S.4
  • 35
    • 0035927221 scopus 로고    scopus 로고
    • Transdermal delivery of naloxone: Effect of water, propylene glycol, ethanol and their binary combinations on permeation through rat skin
    • Panchagnula R., Salve P.S., Thomas N.S., Jain A.K., Ramarao P. Transdermal delivery of naloxone: effect of water, propylene glycol, ethanol and their binary combinations on permeation through rat skin. Int. J. Pharm. 219:2001;95-105
    • (2001) Int. J. Pharm. , vol.219 , pp. 95-105
    • Panchagnula, R.1    Salve, P.S.2    Thomas, N.S.3    Jain, A.K.4    Ramarao, P.5
  • 38
    • 0032992565 scopus 로고    scopus 로고
    • Effects of removal of stratum corneum, delipidization and addition of enhancers, ethanol and L-menthol, on skin permeation of benzoic acid and its 4-n-alkyl substituents in excised guinea pig dorsal skin
    • Kitagawa S., Li H. Effects of removal of stratum corneum, delipidization and addition of enhancers, ethanol and L-menthol, on skin permeation of benzoic acid and its 4-n-alkyl substituents in excised guinea pig dorsal skin. Chem. Pharm. Bull. 47:1999;44-47
    • (1999) Chem. Pharm. Bull. , vol.47 , pp. 44-47
    • Kitagawa, S.1    Li, H.2
  • 39
    • 0033792239 scopus 로고    scopus 로고
    • Effect of L-menthol-ethanol-water system on the systemic absorption of flurbiprofen after repeated topical applications in rabbits
    • Morimoto Y., Hayashi T., Kawabata S., Seki T., Sugibayashi K. Effect of L-menthol-ethanol-water system on the systemic absorption of flurbiprofen after repeated topical applications in rabbits. Biol. Pharm. Bull. 23:2000;1254-1257
    • (2000) Biol. Pharm. Bull. , vol.23 , pp. 1254-1257
    • Morimoto, Y.1    Hayashi, T.2    Kawabata, S.3    Seki, T.4    Sugibayashi, K.5
  • 41
    • 0027988385 scopus 로고
    • Enhanced permeation of polar compounds through human epidermis: I. Permeability and membrane structural changes in the presence of short chain alcohols
    • Goates C.Y., Knutson K. Enhanced permeation of polar compounds through human epidermis: I. Permeability and membrane structural changes in the presence of short chain alcohols. Biochim. Biophys. Acta. 1195:1994;169-179
    • (1994) Biochim. Biophys. Acta , vol.1195 , pp. 169-179
    • Goates, C.Y.1    Knutson, K.2
  • 42
    • 0028861288 scopus 로고
    • Oestradiol permeation across human skin, silastic and snake skin membranes: The effects of ethanol/water co-solvent system
    • Megrab N.A., Williams A.C., Barry B.W. Oestradiol permeation across human skin, silastic and snake skin membranes: the effects of ethanol/water co-solvent system. Int. J. Pharm. 116:1995;101-112
    • (1995) Int. J. Pharm. , vol.116 , pp. 101-112
    • Megrab, N.A.1    Williams, A.C.2    Barry, B.W.3
  • 43
    • 0034951046 scopus 로고    scopus 로고
    • The influence of lysolipids on the spontaneous curvature and bending elasticity of phospholipid membranes
    • Fuller N., Rand R.P. The influence of lysolipids on the spontaneous curvature and bending elasticity of phospholipid membranes. Biophys. J. 81:2001;243-254
    • (2001) Biophys. J. , vol.81 , pp. 243-254
    • Fuller, N.1    Rand, R.P.2
  • 44
    • 2442526343 scopus 로고    scopus 로고
    • Invasomes - novel vesicular carriers for enhanced topical delivery: characterization and skin penetration properties (PhD Thesis), Institute of Pharmaceutical Technology and Biopharmacy, Philipps University Marburg, Germany
    • D.D. Verma, Invasomes - novel vesicular carriers for enhanced topical delivery: characterization and skin penetration properties (PhD Thesis), Institute of Pharmaceutical Technology and Biopharmacy, Philipps University Marburg, Germany, 2002.
    • (2002)
    • Verma, D.D.1
  • 45
    • 0032509925 scopus 로고
    • In-vitro percutaneous absorption enhancement of a lipophilic drug tamoxifen by terpenes
    • Gao S., Singh J. In-vitro percutaneous absorption enhancement of a lipophilic drug tamoxifen by terpenes. J. Control. Release. 51:1988;193-199
    • (1988) J. Control. Release , vol.51 , pp. 193-199
    • Gao, S.1    Singh, J.2


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