Modelling transdermal delivery of high molecular weight drugs from microneedle systems

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 365, Issue 1861, 2007, Pages 2951-2967

  Al Qallaf, Barrak ^a   Das, Diganta Bhusan ^a   Mori, Daisuke ^b   Cui, Zhanfeng ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b Biocom Systems Inc   (Japan)

Author keywords

Microneedle systems; Modelling; Pharmacokinetics; Scaling relationship; Skin patch; Transdermal drug delivery

Indexed keywords

DESIGN; DRUG DELIVERY; MATHEMATICAL MODELS; MODELS; MOLECULAR WEIGHT; PHARMACOKINETICS; TRANSPORT PROPERTIES;

DRUG CONCENTRATION; DRUG TRANSPORT; FUNCTIONAL DEPENDENCE; HIGH MOLECULAR WEIGHT; MICRONEEDLE ARRAYS; MICRONEEDLES; PARAMETRIC ANALYSIS; SCALING ANALYSIS; SCALING RELATIONSHIPS; SKIN PATCH; SURFACE AREA; TRANSDERMAL DELIVERY; TRANSDERMAL DRUG DELIVERY;

NEEDLES;

DRUG;

ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; EQUIPMENT; EQUIPMENT DESIGN; HUMAN; INSTRUMENTATION; METHODOLOGY; MICROFLUIDICS; MICROINJECTION; MOLECULAR WEIGHT; PHARMACOKINETICS; PHYSIOLOGY; SKIN ABSORPTION; SUBCUTANEOUS DRUG ADMINISTRATION;

COMPUTER SIMULATION; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HUMANS; INJECTIONS, SUBCUTANEOUS; MICROFLUIDICS; MICROINJECTIONS; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SKIN ABSORPTION;

EID: 38449095606     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2007.0003     Document Type: Article

References (25)

1. Biocom Systems, Inc. 2006 SKIN-CAD. Simulator for skin pharmacokinetics. Fukuoka, Japan: Biocom Systems, Inc.
2. Buckingham, E. 1914 On physically similar systems; illustrations of the use of dimensional equations. Phys. Rev. 4, 345-376. (doi:10.1103/PhysRev.4.345)
3. Carver, M. B. 1981 Methods of lines solution of differential equations fundamental principles and recent extensions. In Foundations of computer-aided chemical process des ign (eds J. J. Siirola,I. E. Grossmann & G. Stephanopoulos). New York, NY: Engineering Fo undations.
4. Gupta, S. K., Southam, M., Gale, R. & Huang, S. S. 1992 System functionality and physicochemical model of Fentanyl transdermal system. J. Pain Symptom Manage. 7, S17-S26. (doi:10.1016/0885-3924(92)90049-N)
5. Henry, S., McAllister, D. V., Allen, M. G. & Prausnitz, M. R. 1998 Microfabrication microneedles: A novel approach to transdermal drug delivery. J. Pharm. Sci. 87, 922-925. (doi:10.1021/js980042C)
6. Kalia, N. Y., Naik, A., Garrison, J. & Guy, R. H. 2004 Iontophoretic drug delivery. Adv. Drug Deliv. Rev. 56, 619-658. (doi:10.1016/j.addr.2003.10. 026)
7. Kaushik, S., Hord, A. H., Denson, D. D., McAllister, D. V., Smitra, S., Allen, M. G. & Prausnitz, M. R. 2001 Lack of pain associated with microfabricated microneedles. A nesth. Analg. 92,502-504, doi:10.1097/00000539- 200102000-00041
8. Lee, Y. & Hwang, K. 2002 Skin thickness of Korean adults. Surg. Radiol. Anat. 24, 183-189. (doi:10.1007/s00276-002-0034-5)
9. Lv, Y. G., Lie, J. & Xu, B. 2006 Modeling of transdermal drug delivery with a microneedle array. J. Micromech. Microeng. 16, 2492-2501. (doi:10.1088/0960-1317/16/11/034)
10. Mori, D., Kawamata, H. & Tojo, K. 2003 Drug concentration-time profile in the plasma following the dissolution-type transdermal delivery. J. Chem. Eng. Jpn 36, 45-48. (doi:10.1252/jcej.36.45)
11. Naik, A., Kalia, Y. N. & Guy, R. H. 2000 Transdermal drug delivery: overcoming the skin's barrier function. Pharm. Sci. Technol. Today 3, 318-326. (doi:10.1016/S1461-5347(00)00295-9)
12. Park, J. H., Allen, M. G. & Prausnitz, M. R. 2005 Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J. Control. Release 104, 51-66. (doi:10. 1016/j.jconrel.2005.02.002)
13. Prausnitz, M. R., Mitragotri, S. & Langer, R. 2004 Current status and future potential of transdermal drug delivery. Nat. Rev. Drug Discov. 3, 115-124. (doi:10.103 8/nrd1304)
14. Rudman, D. et al. 1990 Effects of human growth hormone in men over 60 years old. N. Engl. J. Med. 323, 1-6.
15. Shah, V. P. 2003 In Transdermal drug delivery (eds R. H. Guy & J. Hadgraft), p. 365, 2nd edn.New York, NY: Marcel Dekker, Inc.
16. Shiflet, A. B. & Shiflet, G. W. 2006 Introduction to computational science: modeling and simulation for the sciences. Wofford College, SC: Princeton University Press.
17. Shikida, M., Hasada, T. & Sato, K. 2006 Fabrication of a hollow needle structure by dicing wet etching and metal deposition. J. Micromech. Microeng. 16, 2230-2239. (doi:10 .1088/0960-1317/16/10/041)
18. Smith, C. R., Erickson, G. J. & Neudorfer, P. O. 1992 Maximum entropy and Bayesian methods. Dordrecht, The Netherlands: Kluwer Academic Publishers.
19. Stoeber, B. & Liepmann, D. 2005 Arrays of hollow out-of-plane microneedles for drug delivery. J. Microelect. Syst. 14, 472-479. (doi:10.1109/JMEMS.2005.844843)
20. Teo, M. A., Shearwood, C., Ng, K. C., Lu, J.&Moochhala, S. 2005 In vitro and in vivo characterization of MEMS microneedles. Bio. Microdevices 7, 47-52. (doi:10.1007/s10544-005-6171-y)
21. Teo, A. L., Shearwood, C., Ng, K. C., Lu, J. & Moochhala, S. 2006 Transdermal microneedles for drug delivery applications. Mater. Sci. Eng. 132, 151-154. (doi:10.1016/j.mseb.2006.02.008)
22. Tojo, K. 2005 Mathematical models of transdermal and topical drug delivery, 2nd edn. Fukuoka, Japan: Biocom Systems, Inc.
23. Williams, A. C. & Barry, B. W. 2004 Penetration enhancers. Adv. Drug Deliv. Rev. 56, 603-618. (doi:10.1016/j.addr.2003.10.025)
24. Xu, X. & Weisel, C. P. 2005 Human respiratory uptake of chloroform and haloketones during showering. J. Expo. Anal. Environ. Epidemiol. 15, 6-16. (doi:10.1038/sj.jea.7500374)
25. Yahya, A. & Manning, C. D. 2004 Determination of material removal rate of an electro-discharge machine using dimensional analysis. J. Phys. D: Appl. Phys. 37, 1467-1471. ( doi:10.1088/0022-3727/37/10/008)