Head-to-tail fusions of camelid antibodies can be expressed in planta and bind in rumen fluid

Biotechnology and Applied Biochemistry

Volumn 53, Issue 2, 2009, Pages 111-122

  Winichayakul, Somrutai ^a   Pernthaner, Anton ^b   Scott, Richard ^a   Vlaming, Ruth ^a   Roberts, Nick ^a  

^a AGRESEARCH GRASSLANDS   (New Zealand)

^b MASSEY UNIVERSITY   (New Zealand)

Author keywords

Camelid; Endoplasmic reticulum; Rumen fluid; Transgenic plant; Tumour necrosis factor (TNF ); Variable heavy chain antibody from camelid (VHH)

Indexed keywords

CAMELID; ENDOPLASMIC RETICULUM; RUMEN FLUID; TRANSGENIC PLANT; VARIABLE HEAVY-CHAIN ANTIBODY FROM CAMELID (VHH);

ANTIGENS; CHLOROPHYLL; CYTOLOGY; FLUIDS; GLYCOPROTEINS; MACROPHAGES; PLANTS (BOTANY); TUMORS;

ANTIBODIES;

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; IMMUNOGLOBULIN HEAVY CHAIN; TUMOR NECROSIS FACTOR ALPHA; VEGETABLE PROTEIN; ANTIBODY; HYBRID PROTEIN;

5' UNTRANSLATED REGION; ANTIGEN BINDING; ARABIDOPSIS; ARTICLE; ARTIODACTYLA; CELL ORGANELLE; CELL TRANSFORMATION; CELL VACUOLE; CHLOROPLAST; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENDOPLASMIC RETICULUM; EXPRESSION VECTOR; IN VITRO STUDY; NONHUMAN; PLANT CELL; PROKARYOTE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN TARGETING; RUMINANT STOMACH; AMINO ACID SEQUENCE; ANIMAL; BODY FLUID; CHEMISTRY; CYTOLOGY; GENE EXPRESSION; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLANT LEAF; TRANSGENIC PLANT;

ARABIDOPSIS THALIANA; CAMELIDAE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ARABIDOPSIS; BASE SEQUENCE; BODY FLUIDS; CAMELIDS, NEW WORLD; GENE EXPRESSION; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; PLANT LEAVES; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS; RUMEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67649637576     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20080076     Document Type: Article

References (52)

1. Floss, D. M., Falkenburg, D. and Conrad, U. (2007) Transgenic Res. 16, 315-332
2. Gasser, B. and Mattanovich, D. (2007) Biotechnol. Lett. 29, 201-212
3. Stoger, E., Sack, M., Nicholson, L., Fischer, R. and Christou, P. (2005) Curr. Pharm. Des. 11, 2439-2457
4. Pavlou, A. K. and Belsey, M. J. (2005) Eur. J. Pharm. Biopharm. 59, 389-396
5. De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S. and Wyns, L. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 4586-4591
6. Dumoulin, M., Conrath, K., Van Meirhaeghe, A., Meersman, F., Heremans, K., Frenken, L. G. J., Muyldermans, S., Wyns, L. and Matagne, A. (2002) Protein Sci. 11, 500-515
7. Dolk, E., van der Vaart, M., Lutje Hulsik, D., Vriend, G., de Haard, H., Spinelli, S., Cambillau, C., Frenken, L. and Verrips, T. (2005) Appl. Environ. Microbiol. 71, 442-450
8. Harmsen, M. M. and De Haard, H. J. (2007) Appl. Microbiol. Biotechnol. 77, 13-22
9. Van der Linden, R. H., de Geus, B., Frenken, G. J., Peters, H. and Verrips, C. T. (2000) J. Biotechnol. 80, 261-270
10. Ghahroudi, M. A., Desmyter, A., Wyns, L., Hamers, R. and Muyldermans, S. (1997) FEBS Lett. 414, 521-526
11. Joosten, V., Lokman, C., Van den Hondel, C. A. and Punt, P. J. (2003) Microb. Cell Fact. 2, 1-15
12. Muyldermans, S. (2001) J. Biotechnol. 74, 277-302
13. Monger, W., Alamillo, J. M., Sola, I., Perrin, Y., Bestagno, M., Burrone, O. R., Sabella, P., Plana-Duran, J., Enjuanes, L., Garcia, J. A. and Lomonossoff, G. P. (2006) Plant Biotechnol. J. 4, 623-631
14. Conrath, K., Lauwereys, M., Wyns, L. and Muyldermans, S. (2001) J. Biol. Chem. 276, 7346-7350
15. Maass, D. R., Sepulveda, J., Pernthaner, A. and Shoemaker, C. B. (2007) J. Immunol. Methods 324, 13-25
16. Brown, S. J. and Mayer, L. (2007) Am. J. Gastroenterol. 102, 2058-2069
17. Ruuls, S. R. and Sedgwick, J. D. (1999) Am. J. Hum. Genet. 65, 294-301
18. Clancy, R., Ren, Z., Turton, J., Pang, G. andWettstein, A. (2007) Digest. Liver Dis. 39, 445-451
19. Coussens, P. M., Verman, N., Coussens, M. A., Elftman, M. D. and McNulty, A. M. (2004) Infect. Immun. 72, 1409-1422
20. Adams, J. L., Collins, M. T. and Czuprynski, C. J. (1996) Can. J. Vet. Res. 60, 257-262
21. Pernthaner, A., Cole, S. A., Morrison, L. and Hein,W. R. (2005) Infect. Immun. 73, 2175-2183
22. Mimura, T. and Mimura, T. (2007) Nippon Rinsho 65, 1282-1286
23. Schreiber, S. and Schreiber, S. (2007) Dtsch.Med.Wochenschr. 132, 1770-1774
24. De Jaeger, G., Fiers, E., Eeckhout, D. and Depicker, A. (2000) FEBS Lett. 467, 316-320
25. Roberts, N. J., Scott, R. W. and Tzen, J. T. (2008) Open Biotechnol. J. 2, 13-21
26. Streatfield, S. J. (2007) Plant Biotechnol. J. 5, 2-15
27. Giddings, G. (2001) Curr. Opin. Biotechnol. 12, 450-454
28. Rose, A. B. (2004) Plant. J. 40, 744-751
29. Norris, S. R., Meyer, S. E. and Callis, J. (1993) Plant Mol. Biol. 21, 859-906
30. Rose, A. B. and Beliakoff, J. A. (2000) Plant Physiol. 122, 535-542
31. Wong, E. Y., Hironaka, C. M. and Fischhoff, D. A. (1992) Plant Mol. Biol. 20, 81-93
32. Joshi, C. P., Zhou, H., Huang, X. and Chiang, V. L. (1997) Plant Mol. Biol. 35, 993-1001
33. Kozak, M. (1978) Cell 15, 1109-1123
34. Brown, C. M., Stockwell, P. A., Trotman, C. N. and Tate, W. P. (1990) Nucleic Acids Res. 18, 2079-2086
35. Haran, S., Logendra, S., Seskar, M., Bratanova, M. and Raskin, I. (2000) Plant Physiol. 124, 615-626
36. Pfeffer, S. R. (2007) Annu. Rev. Biochem. 76, 629-645
37. Neuhaus, J. M., Sticher, L., Meins, F. Jr. and Boller, T. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 10362-10366
38. Di Sansebastiano, G. P., Paris, N., Marc-Martin, S. and Neuhaus, J. M. (1998) Plant J. 15, 449-457
39. Gleave, A. P. (1992) Plant Mol. Biol. 20, 1203-1207
40. Martinez-Trujillo, M., Limones-Briones, V., Cabrera-Ponce, J. L. and Herrera-Estrella, L., (2004) Plant Mol. Biol. Rep. 22, 63-70
41. Murashige, T. and Skoog, F. (1962) Physiol. Plant. 15, 473-497
42. Flick, D. A. and Gifford, G. E. (1984) J. Immunol. Methods 68, 167-175
43. Schouten, A., Roosien, J., van Engelen, F. A., de Jong, G. A., Borst-Vrenssen, A. W., Zilverentant, J. F., Bosch, D., Stiekema, W. J., Gommers, F. J., Schots, A. and Bakker, J. (1996) Plant Mol. Biol. 30, 781-793
44. Ziegler, A., Cowan, G. H., Torrance, L., Ross, H. A. and Davies, H. V. (2000) Mol. Breeding 6, 327-335
45. Ismaili, A., Jalali-Javaran, M., Rasaee, M. J., Rahbarizadeh, F., Forouzandeh-Moghadam, M. and Memari, H. R. (2007) Biotechnol. Appl. Biochem. 47, 11-19
46. Leedle, J. A. Z., Bryant, M. P. and Hespell, R. B. (1982) Appl. Environ. Microbiol. 22, 402-412
47. Saerens, D., Ghassabeh, G. H. and Muyldermans, S. (2008) Curr. Opin. Pharm. 8, 1-9
48. Rahbarizadeh, F., Rasaee, M. J., Forouzandeh, M., Allameh, A. A. and Sadronddiny, E. (2004) Hybrid Hybridomics 23, 151-159
49. Gibbs, W. (2005) Sci. Am. 293, 78-83
50. Pant, N., Hultberg, A., Zhao, Y., Svensson, L., Pan-Hammarstrom, Q., Johansen, K., Pouwels, P. H., Ruggeri, F. M., Hermans, P. and Frenken, L. et al. (2006) J. Infect. Dis. 194, 1580-1588
51. Scott, R. W., Arcus, V. L. and Roberts, N. J. (2007) World Pat. WO/2007/ 045019
52. Fischer, R., Liao, Y.-C., Hoffmann, K., Schillberg, S. and Emans, N. (1999) Biol. Chem. 380, 825-839