Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera

Toxicon

Volumn 47, Issue 3, 2006, Pages 364-368

  Harrison, R A ^a   Hasson, S S ^b   Harmsen, M ^c   Laing, G D ^a   Conrath, K ^d   Theakston, R D G ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b University of Science and Technology   (Yemen)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Antivenom; Camel; Echis ocellatus; Llama

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; SNAKE VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; ARTIODACTYLA; BLEEDING; CAMEL; CONTROLLED STUDY; ENVENOMATION; HEAVY CHAIN; IMMUNIZATION; LLAMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIVENINS; CAMELIDS, NEW WORLD; CAMELS; HEMORRHAGE; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; MICE; SNAKE BITES; VIPER VENOMS; VIPERIDAE;

ANIMALIA; ARTIODACTYLA; CAMELIDAE; ECHIS OCELLATUS; EQUIDAE; LAMA (MAMMAL); LAMA GLAMA; OVIS ARIES; SERPENTES; VIPERINAE;

EID: 33644512108     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2005.10.017     Document Type: Article

References (20)

1. J.-P. Chippaux The treatment of snake bites: analysis of requirements and assessment of therapeutic efficacy in tropical Africa A. Menez Perspectives in Molecular Toxinology 2002 Wiley New York 457 472
2. V. Cortez-Retamozo, M. Lauwereys, G.H. Hassanzadeh, M. Gobert, K.E. Conrath, S. Muldermans, P. de Baetselier, and H. Revets Efficient tumor targeting by single domain antibody fragments of camels International Journal of Cancer 98 2002 456 462
3. J.M. Gutierrez, G. Leon, G. Rojas, B. Lamonte, A. Rucavado, and F. Chaves Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom Toxicon 36 1998 1529 1538
4. J.M. Gutierrez, A. Rucavado, and M. Ovadia Metalloproteinase inhibitors in snakebite envenomations Drug Discovery Today 1999 532 533
5. J.M. Gutierrez, E. Rojas, L. Quesada, G. Leon, J. Nunez, G.D. Laing, M. Sasa, J.M. Renjifo, A. Nasidi, D.A. Warrell, R.D.G. Theakston, and G. Rojas Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa Transactions of the Royal Society of Tropical Medicine and Hygiene 99 2005 468 475
6. C. Hamers-Casterman, T. Atarouch, S. Muyldermans, G. Robinson, C. Hamers, E.B. Songa, N. Bendahman, and R. Hamers Naturally occurring antibodies devoid of light chains Nature 363 1993 446 448
7. G.D. Laing, P.B. Clissa, R.D.G. Theakston, A.M. Moura-da-Silva, and M.J. Taylor Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis European Journal of Immunology 33 2003 3458 3463
8. D. Lalloo, and D.G. Theakston Snake antivenoms Journal of Toxicology Clinical Toxicology 41 3 2003 277 290
9. G. Leon, G. Rojas, B. Lamonte, and J.M. Gutierrez Immunoglobulin G and F(ab′)2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom Toxicon 35 1997 1627 1637
10. G. Leon, J.M. Valverde, G. Rojas, B. Lamonte, and J.M. Gutierrez Comparative study of the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom Toxicon 38 2000 233 244
11. F. Meddeb-Mouelhi, B. Bouhaouala-Zahar, Z. Benlasfar, M. Hammadi, T. Mejri, M. Moslah, H. Karoui, T. Khorchani, and M. El Ayeb Immunized camel sera and derived immunoglobulin subclasses neutralizing Androctonus australis hector scorpion toxins Toxicon 42 2003 785 791
12. A.M. Moura-da-Silva, G.D. Laing, M.J.I. Paine, J. Dennison, V. Politi, J.M. Crampton, and R.D.G. Theakston Processing of pro-TNF-α by venom metalloproteinases: a hypothesis towards explaining local tissue damage following snake bite European Journal of Immunology 26 1996 2000 2005
13. R.N. Pugh, and R.D.G. Theakston A clinical study of viper bite poisoning Annals of Tropical Medicine and Parasitology 81 2 1987 135 149
14. J. Perales, A. Neves-Ferreira, R.H. Valente, and G.B. Domont Natural inhibitors of snake hemorrhagic metalloproteinases Toxicon 45 2005 1013 1020
15. S. Sriprapat, S. Aeksowan, S. Sapsutthipas, C. Chotwiwatthanakun, P. Suttijitpaisal, R. Pratanaphon, O. Khow, V. Sitprija, and K. Ratanabanangkoon The impact of a low dose, low volume, multi-site immunization on the production of therapeutic antivenoms in Thailand Toxicon 41 2003 57 64
16. Pugh, R.N., Theakston, R.D.G., 1980. Incidence and mortality of snake bite in savanna Nigeria. The Lancet 29:1181-1183.
17. J.F. Trape, G. Pison, E. Guyavarch, and Y. Mane High mortality from snakebite in South-eastern Senegal Transactions of the Royal Society of Tropical Medicine and Hygiene 95 4 2001 420 423
18. R.H. van der Linden, L.G. Frenken, B. de Geus, M.M. Harmsen, R.C. Ruuls, W. Stok, L. de Ron, S. Wilson, P. Davis, and C.T. Verrips Comparison of the physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies Biochimica et Biophysica Acta 1431 1999 37 46
19. D.A. Warrell The global problem of snake bite: its prevention and treatment P. Gopalakrishnakone C.K Tu Recent Advances in Toxinology Research (1) 1992 National University of Singapore Publishers Singapore 121 153
20. D.A. Warrell, N. Davidson, B.M. Greenwood, L. Ormerod, H.M. Pope, J. Watkins, and C.R. Prentice Poisoning by the bites of the saw scaled or carpet viper (Echis carinatus) in Nigeria Quarterly Journal of Medicine 181 1977 33 62