Increasing the serum persistence of an IgG fragment by random mutagenesis

Nature Biotechnology

Volumn 15, Issue 7, 1997, Pages 637-640

  Ghetie, Victor ^a   Popov, Serguei ^a   Borvak, Jozef ^a   Radu, Caius ^a   Matesoi, Diana ^b   Medesan, Corneliu ^c   Ober, Raimund J ^a   Ward, E Sally ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Baylor Research Institute   (United Kingdom)

^c STEFAN S NICOLAU INSTITUTE OF VIROLOGY   (Romania)

Author keywords

Antibody engineering; Phage display; Pharmacokinetics; Surface plasmon resonance

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN G; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; THREONINE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HALF LIFE TIME; MOUSE; MUTAGENESIS; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; SERUM;

ANIMALS; BASE SEQUENCE; BIOTECHNOLOGY; HALF-LIFE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; MICE; MUTAGENESIS; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN ENGINEERING; RECEPTORS, IGG;

MURINAE;

EID: 0030796064     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0797-637     Document Type: Article

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