-
1
-
-
1142275269
-
Age-related changes in lymphocyte development and function
-
Linton P.J., and Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 5 (2004) 133-139
-
(2004)
Nat Immunol
, vol.5
, pp. 133-139
-
-
Linton, P.J.1
Dorshkind, K.2
-
2
-
-
58149235466
-
Telomeres and telomerase in stem cells during aging and disease
-
Ju Z., and Rudolph K.L. Telomeres and telomerase in stem cells during aging and disease. Genome Dyn 1 (2006) 84-103
-
(2006)
Genome Dyn
, vol.1
, pp. 84-103
-
-
Ju, Z.1
Rudolph, K.L.2
-
3
-
-
34247390746
-
Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases
-
Kudlow B.A., Kennedy B.K., and Monnat Jr. R.J. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol 8 (2007) 394-404
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 394-404
-
-
Kudlow, B.A.1
Kennedy, B.K.2
Monnat Jr., R.J.3
-
5
-
-
85047689866
-
Telomeres, stem cells, senescence, and cancer
-
Sharpless N.E., and DePinho R.A. Telomeres, stem cells, senescence, and cancer. J Clin Invest 113 (2004) 160-168
-
(2004)
J Clin Invest
, vol.113
, pp. 160-168
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
6
-
-
33750030758
-
The regulation of INK4/ARF in cancer and aging
-
Kim W.Y., and Sharpless N.E. The regulation of INK4/ARF in cancer and aging. Cell 127 (2006) 265-275
-
(2006)
Cell
, vol.127
, pp. 265-275
-
-
Kim, W.Y.1
Sharpless, N.E.2
-
7
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X., Soron G., Cooper B., Brayton C., et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (2002) 45-53
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
-
8
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier B., Gluba W., Bernier B., Turner T., Mohammad K., Guise T., Sutherland A., Thorner M., and Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes Dev 18 (2004) 306-319
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
Turner, T.4
Mohammad, K.5
Guise, T.6
Sutherland, A.7
Thorner, M.8
Scrable, H.9
-
9
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway
-
This paper shows that increased expression of Arf and wild-type p53 protects mice from both cancer and aging-related damages, indicating an anti-aging role of Arf/p53 pathway presumably through enhanced DNA damage repair.
-
Matheu A., Maraver A., Klatt P., Flores I., Garcia-Cao I., Borras C., Flores J.M., Vina J., Blasco M.A., and Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448 (2007) 375-379. This paper shows that increased expression of Arf and wild-type p53 protects mice from both cancer and aging-related damages, indicating an anti-aging role of Arf/p53 pathway presumably through enhanced DNA damage repair.
-
(2007)
Nature
, vol.448
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
Flores, J.M.7
Vina, J.8
Blasco, M.A.9
Serrano, M.10
-
10
-
-
33846921755
-
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
-
This paper demonstrates that increased activity of p53 causes premature aging of HSCs, while lower dose of p53 abolishes age-associated decline of HSC repopulating capacity. Together with references [7] and [8], this study supports a pro-aging role of p53 pathway.
-
Dumble M., Moore L., Chambers S.M., Geiger H., Van Zant G., Goodell M.A., and Donehower L.A. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood 109 (2007) 1736-1742. This paper demonstrates that increased activity of p53 causes premature aging of HSCs, while lower dose of p53 abolishes age-associated decline of HSC repopulating capacity. Together with references [7] and [8], this study supports a pro-aging role of p53 pathway.
-
(2007)
Blood
, vol.109
, pp. 1736-1742
-
-
Dumble, M.1
Moore, L.2
Chambers, S.M.3
Geiger, H.4
Van Zant, G.5
Goodell, M.A.6
Donehower, L.A.7
-
11
-
-
0032937751
-
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
-
Rane S.G., Dubus P., Mettus R.V., Galbreath E.J., Boden G., Reddy E.P., and Barbacid M. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet 22 (1999) 44-52
-
(1999)
Nat Genet
, vol.22
, pp. 44-52
-
-
Rane, S.G.1
Dubus, P.2
Mettus, R.V.3
Galbreath, E.J.4
Boden, G.5
Reddy, E.P.6
Barbacid, M.7
-
12
-
-
0032849353
-
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity
-
Tsutsui T., Hesabi B., Moons D.S., Pandolfi P.P., Hansel K.S., Koff A., and Kiyokawa H. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol 19 (1999) 7011-7019
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7011-7019
-
-
Tsutsui, T.1
Hesabi, B.2
Moons, D.S.3
Pandolfi, P.P.4
Hansel, K.S.5
Koff, A.6
Kiyokawa, H.7
-
13
-
-
0018358261
-
Senescent human diploid cells in culture: survival, DNA synthesis and morphology
-
Matsumura T., Zerrudo Z., and Hayflick L. Senescent human diploid cells in culture: survival, DNA synthesis and morphology. J Gerontol 34 (1979) 328-334
-
(1979)
J Gerontol
, vol.34
, pp. 328-334
-
-
Matsumura, T.1
Zerrudo, Z.2
Hayflick, L.3
-
14
-
-
20344373118
-
The role of CD8+ T-cell replicative senescence in human aging
-
Effros R.B., Dagarag M., Spaulding C., and Man J. The role of CD8+ T-cell replicative senescence in human aging. Immunol Rev 205 (2005) 147-157
-
(2005)
Immunol Rev
, vol.205
, pp. 147-157
-
-
Effros, R.B.1
Dagarag, M.2
Spaulding, C.3
Man, J.4
-
15
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig U., Ferreira M., Condel L., Carey D., and Sedivy J.M. Cellular senescence in aging primates. Science 311 (2006) 1257
-
(2006)
Science
, vol.311
, pp. 1257
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.M.5
-
17
-
-
34548153747
-
How stem cells age and why this makes us grow old
-
Sharpless N.E., and DePinho R.A. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8 (2007) 703-713
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 703-713
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
18
-
-
3543043128
-
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
-
Chang S., Multani A.S., Cabrera N.G., Naylor M.L., Laud P., Lombard D., Pathak S., Guarente L., and DePinho R.A. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36 (2004) 877-882
-
(2004)
Nat Genet
, vol.36
, pp. 877-882
-
-
Chang, S.1
Multani, A.S.2
Cabrera, N.G.3
Naylor, M.L.4
Laud, P.5
Lombard, D.6
Pathak, S.7
Guarente, L.8
DePinho, R.A.9
-
19
-
-
0037480961
-
Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
-
Allsopp R.C., Morin G.B., DePinho R., Harley C.B., and Weissman I.L. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102 (2003) 517-520
-
(2003)
Blood
, vol.102
, pp. 517-520
-
-
Allsopp, R.C.1
Morin, G.B.2
DePinho, R.3
Harley, C.B.4
Weissman, I.L.5
-
20
-
-
34250017413
-
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
-
Ju Z., Jiang H., Jaworski M., Rathinam C., Gompf A., Klein C., Trumpp A., and Rudolph K.L. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med 13 (2007) 742-747
-
(2007)
Nat Med
, vol.13
, pp. 742-747
-
-
Ju, Z.1
Jiang, H.2
Jaworski, M.3
Rathinam, C.4
Gompf, A.5
Klein, C.6
Trumpp, A.7
Rudolph, K.L.8
-
21
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
This paper examines HSC function with age in mice deficient in several DNA repair pathways and shows that HSC repopulating capacity and self-renewal is defective in the absence of these pathways. This study also provides evidence that endogenous DNA damage accumulates with age in HSCs and supports that DNA damage accumulation plays an important role in HSC aging.
-
Rossi D.J., Bryder D., Seita J., Nussenzweig A., Hoeijmakers J., and Weissman I.L. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447 (2007) 725-729. This paper examines HSC function with age in mice deficient in several DNA repair pathways and shows that HSC repopulating capacity and self-renewal is defective in the absence of these pathways. This study also provides evidence that endogenous DNA damage accumulates with age in HSCs and supports that DNA damage accumulation plays an important role in HSC aging.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
Weissman, I.L.6
-
22
-
-
34147222679
-
Telomerase induction in T cells: a cure for aging and disease?
-
Effros R.B. Telomerase induction in T cells: a cure for aging and disease?. Exp Gerontol 42 (2007) 416-420
-
(2007)
Exp Gerontol
, vol.42
, pp. 416-420
-
-
Effros, R.B.1
-
23
-
-
58149192453
-
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes
-
This paper represents the first study to use a pharmacological telomerase-based approach to enhance immune function. By showing that a small molecule telomerase activator (TAT2) increases antiviral function of senescent CD8+ CTLs in chronic viral infection, this study provides evidence that telomere shortening plays an important role in immunosenescence caused by chronic infection.
-
Fauce S.R., Jamieson B.D., Chin A.C., Mitsuyasu R.T., Parish S.T., Ng H.L., Kitchen C.M., Yang O.O., Harley C.B., and Effros R.B. Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol 181 (2008) 7400-7406. This paper represents the first study to use a pharmacological telomerase-based approach to enhance immune function. By showing that a small molecule telomerase activator (TAT2) increases antiviral function of senescent CD8+ CTLs in chronic viral infection, this study provides evidence that telomere shortening plays an important role in immunosenescence caused by chronic infection.
-
(2008)
J Immunol
, vol.181
, pp. 7400-7406
-
-
Fauce, S.R.1
Jamieson, B.D.2
Chin, A.C.3
Mitsuyasu, R.T.4
Parish, S.T.5
Ng, H.L.6
Kitchen, C.M.7
Yang, O.O.8
Harley, C.B.9
Effros, R.B.10
-
24
-
-
11244310960
-
Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita
-
Knudson M., Kulkarni S., Ballas Z.K., Bessler M., and Goldman F. Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita. Blood 105 (2005) 682-688
-
(2005)
Blood
, vol.105
, pp. 682-688
-
-
Knudson, M.1
Kulkarni, S.2
Ballas, Z.K.3
Bessler, M.4
Goldman, F.5
-
25
-
-
34548828783
-
Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita
-
Alter B.P., Baerlocher G.M., Savage S.A., Chanock S.J., Weksler B.B., Willner J.P., Peters J.A., Giri N., and Lansdorp P.M. Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood 110 (2007) 1439-1447
-
(2007)
Blood
, vol.110
, pp. 1439-1447
-
-
Alter, B.P.1
Baerlocher, G.M.2
Savage, S.A.3
Chanock, S.J.4
Weksler, B.B.5
Willner, J.P.6
Peters, J.A.7
Giri, N.8
Lansdorp, P.M.9
-
26
-
-
13144305133
-
The rate of telomere sequence loss in human leukocytes varies with age
-
Frenck Jr. R.W., Blackburn E.H., and Shannon K.M. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A 95 (1998) 5607-5610
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 5607-5610
-
-
Frenck Jr., R.W.1
Blackburn, E.H.2
Shannon, K.M.3
-
27
-
-
0035845259
-
Telomere shortening in atherosclerosis
-
Samani N.J., Boultby R., Butler R., Thompson J.R., and Goodall A.H. Telomere shortening in atherosclerosis. Lancet 358 (2001) 472-473
-
(2001)
Lancet
, vol.358
, pp. 472-473
-
-
Samani, N.J.1
Boultby, R.2
Butler, R.3
Thompson, J.R.4
Goodall, A.H.5
-
28
-
-
0344990162
-
Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders
-
Obana N., Takagi S., Kinouchi Y., Tokita Y., Sekikawa A., Takahashi S., Hiwatashi N., Oikawa S., and Shimosegawa T. Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders. Intern Med 42 (2003) 150-153
-
(2003)
Intern Med
, vol.42
, pp. 150-153
-
-
Obana, N.1
Takagi, S.2
Kinouchi, Y.3
Tokita, Y.4
Sekikawa, A.5
Takahashi, S.6
Hiwatashi, N.7
Oikawa, S.8
Shimosegawa, T.9
-
29
-
-
0042140590
-
Telomere dysfunction: a potential cancer predisposition factor
-
Wu X., Amos C.I., Zhu Y., Zhao H., Grossman B.H., Shay J.W., Luo S., Hong W.K., and Spitz M.R. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst 95 (2003) 1211-1218
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1211-1218
-
-
Wu, X.1
Amos, C.I.2
Zhu, Y.3
Zhao, H.4
Grossman, B.H.5
Shay, J.W.6
Luo, S.7
Hong, W.K.8
Spitz, M.R.9
-
30
-
-
58049216794
-
p53 regulates hematopoietic stem cell quiescence
-
Liu Y., Elf S.E., Miyata Y., Sashida G., Liu Y., Huang G., Di Giandomenico S., Lee J.M., Deblasio A., Menendez S., et al. p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell 4 (2009) 37-48
-
(2009)
Cell Stem Cell
, vol.4
, pp. 37-48
-
-
Liu, Y.1
Elf, S.E.2
Miyata, Y.3
Sashida, G.4
Liu, Y.5
Huang, G.6
Di Giandomenico, S.7
Lee, J.M.8
Deblasio, A.9
Menendez, S.10
-
31
-
-
52049117400
-
Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice
-
Chen J., Ellison F.M., Keyvanfar K., Omokaro S.O., Desierto M.J., Eckhaus M.A., and Young N.S. Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice. Exp Hematol 36 (2008) 1236-1243
-
(2008)
Exp Hematol
, vol.36
, pp. 1236-1243
-
-
Chen, J.1
Ellison, F.M.2
Keyvanfar, K.3
Omokaro, S.O.4
Desierto, M.J.5
Eckhaus, M.A.6
Young, N.S.7
-
33
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin L., Artandi S.E., Shen Q., Tam A., Lee S.L., Gottlieb G.J., Greider C.W., and DePinho R.A. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97 (1999) 527-538
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.L.5
Gottlieb, G.J.6
Greider, C.W.7
DePinho, R.A.8
-
34
-
-
33845892109
-
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
-
Choudhury A.R., Ju Z., Djojosubroto M.W., Schienke A., Lechel A., Schaetzlein S., Jiang H., Stepczynska A., Wang C., Buer J., et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 39 (2007) 99-105
-
(2007)
Nat Genet
, vol.39
, pp. 99-105
-
-
Choudhury, A.R.1
Ju, Z.2
Djojosubroto, M.W.3
Schienke, A.4
Lechel, A.5
Schaetzlein, S.6
Jiang, H.7
Stepczynska, A.8
Wang, C.9
Buer, J.10
-
35
-
-
34548179310
-
Cancer and ageing: convergent and divergent mechanisms
-
Serrano M., and Blasco M.A. Cancer and ageing: convergent and divergent mechanisms. Nat Rev Mol Cell Biol 8 (2007) 715-722
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 715-722
-
-
Serrano, M.1
Blasco, M.A.2
-
36
-
-
46449083569
-
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
-
INK4a and Arf may play apposing roles in mammalian aging.
-
INK4a and Arf may play apposing roles in mammalian aging.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 825-836
-
-
Baker, D.J.1
Perez-Terzic, C.2
Jin, F.3
Pitel, K.4
Niederlander, N.J.5
Jeganathan, K.6
Yamada, S.7
Reyes, S.8
Rowe, L.9
Hiddinga, H.J.10
-
37
-
-
0033567101
-
Accelerated development and aging of the immune system in p53-deficient mice
-
Ohkusu-Tsukada K., Tsukada T., and Isobe K. Accelerated development and aging of the immune system in p53-deficient mice. J Immunol 163 (1999) 1966-1972
-
(1999)
J Immunol
, vol.163
, pp. 1966-1972
-
-
Ohkusu-Tsukada, K.1
Tsukada, T.2
Isobe, K.3
-
38
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
-
Cheng T., Rodrigues N., Shen H., Yang Y., Dombkowski D., Sykes M., and Scadden D.T. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287 (2000) 1804-1808
-
(2000)
Science
, vol.287
, pp. 1804-1808
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
Yang, Y.4
Dombkowski, D.5
Sykes, M.6
Scadden, D.T.7
-
39
-
-
34147168247
-
A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning
-
van Os R., Kamminga L.M., Ausema A., Bystrykh L.V., Draijer D.P., van Pelt K., Dontje B., and de Haan G. A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning. Stem Cells 25 (2007) 836-843
-
(2007)
Stem Cells
, vol.25
, pp. 836-843
-
-
van Os, R.1
Kamminga, L.M.2
Ausema, A.3
Bystrykh, L.V.4
Draijer, D.P.5
van Pelt, K.6
Dontje, B.7
de Haan, G.8
-
40
-
-
58149236959
-
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
-
CIP is important for maintaining self-renewal of leukemia/hematopoietic stem cells.
-
CIP is important for maintaining self-renewal of leukemia/hematopoietic stem cells.
-
(2009)
Nature
, vol.457
, pp. 51-56
-
-
Viale, A.1
De Franco, F.2
Orleth, A.3
Cambiaghi, V.4
Giuliani, V.5
Bossi, D.6
Ronchini, C.7
Ronzoni, S.8
Muradore, I.9
Monestiroli, S.10
-
41
-
-
14844363448
-
Mechanisms that limit the in vitro proliferative potential of human CD8+ T lymphocytes
-
Migliaccio M., Raj K., Menzel O., and Rufer N. Mechanisms that limit the in vitro proliferative potential of human CD8+ T lymphocytes. J Immunol 174 (2005) 3335-3343
-
(2005)
J Immunol
, vol.174
, pp. 3335-3343
-
-
Migliaccio, M.1
Raj, K.2
Menzel, O.3
Rufer, N.4
-
42
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy J., Torrice C., Ramsey M.R., Kovalev G.I., Al-Regaiey K., Su L., and Sharpless N.E. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 114 (2004) 1299-1307
-
(2004)
J Clin Invest
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
43
-
-
34147156889
-
Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
-
Edwards M.G., Anderson R.M., Yuan M., Kendziorski C.M., Weindruch R., and Prolla T.A. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics 8 (2007) 80-92
-
(2007)
BMC Genomics
, vol.8
, pp. 80-92
-
-
Edwards, M.G.1
Anderson, R.M.2
Yuan, M.3
Kendziorski, C.M.4
Weindruch, R.5
Prolla, T.A.6
-
44
-
-
33749187810
-
p16INK4a induces an age-dependent decline in islet regenerative potential
-
Krishnamurthy J., Ramsey M.R., Ligon K.L., Torrice C., Koh A., Bonner-Weir S., and Sharpless N.E. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443 (2006) 453-457
-
(2006)
Nature
, vol.443
, pp. 453-457
-
-
Krishnamurthy, J.1
Ramsey, M.R.2
Ligon, K.L.3
Torrice, C.4
Koh, A.5
Bonner-Weir, S.6
Sharpless, N.E.7
-
45
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
-
Janzen V., Forkert R., Fleming H.E., Saito Y., Waring M.T., Dombkowski D.M., Cheng T., DePinho R.A., Sharpless N.E., and Scadden D.T. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443 (2006) 421-426
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.E.3
Saito, Y.4
Waring, M.T.5
Dombkowski, D.M.6
Cheng, T.7
DePinho, R.A.8
Sharpless, N.E.9
Scadden, D.T.10
-
46
-
-
33749171885
-
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
-
Molofsky A.V., Slutsky S.G., Joseph N.M., He S., Pardal R., Krishnamurthy J., Sharpless N.E., and Morrison S.J. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443 (2006) 448-452
-
(2006)
Nature
, vol.443
, pp. 448-452
-
-
Molofsky, A.V.1
Slutsky, S.G.2
Joseph, N.M.3
He, S.4
Pardal, R.5
Krishnamurthy, J.6
Sharpless, N.E.7
Morrison, S.J.8
-
47
-
-
56549120340
-
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf
-
INK4a or Arf expression in aged lymphoid progenitors rescues these defects, indicating an important role of INK4a/Arf locus in lymphoid progenitor aging in mice.
-
INK4a or Arf expression in aged lymphoid progenitors rescues these defects, indicating an important role of INK4a/Arf locus in lymphoid progenitor aging in mice.
-
(2008)
Genes Dev
, vol.22
, pp. 3115-3120
-
-
Signer, R.A.1
Montecino-Rodriguez, E.2
Witte, O.N.3
Dorshkind, K.4
-
48
-
-
67651180787
-
-
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim JG, Thomas NE, Sharpless NE: Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging. Aging Cell 2009, doi:10.1111/j.1474-9726.2009.00489.x. This paper and reference [49] provide evidences that p16INK4a expression in human peripheral blood lymphocytes is associated with chronologic age, genetics, and factors that affect the degree of human aging. These data validate the observations in model system and indicate that p16INK4a expression, determined by chronological age, environmental exposures and genetics, acts as a biomarker of human molecular age.
-
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim JG, Thomas NE, Sharpless NE: Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging. Aging Cell 2009, doi:10.1111/j.1474-9726.2009.00489.x. This paper and reference [49] provide evidences that p16INK4a expression in human peripheral blood lymphocytes is associated with chronologic age, genetics, and factors that affect the degree of human aging. These data validate the observations in model system and indicate that p16INK4a expression, determined by chronological age, environmental exposures and genetics, acts as a biomarker of human molecular age.
-
-
-
-
49
-
-
64549083268
-
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis
-
Liu Y., Sanoff H.K., Cho H., Burd C.E., Torrice C., Mohlke K.L., Ibrahim J.G., Thomas N.E., and Sharpless N.E. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS ONE 4 (2009) e5027
-
(2009)
PLoS ONE
, vol.4
-
-
Liu, Y.1
Sanoff, H.K.2
Cho, H.3
Burd, C.E.4
Torrice, C.5
Mohlke, K.L.6
Ibrahim, J.G.7
Thomas, N.E.8
Sharpless, N.E.9
-
50
-
-
46849122501
-
p16(INK4a) translation suppressed by miR-24
-
Lal A., Kim H.H., Abdelmohsen K., Kuwano Y., Pullmann Jr. R., Srikantan S., Subrahmanyam R., Martindale J.L., Yang X., Ahmed F., et al. p16(INK4a) translation suppressed by miR-24. PLoS ONE 3 (2008) e1864
-
(2008)
PLoS ONE
, vol.3
-
-
Lal, A.1
Kim, H.H.2
Abdelmohsen, K.3
Kuwano, Y.4
Pullmann Jr., R.5
Srikantan, S.6
Subrahmanyam, R.7
Martindale, J.L.8
Yang, X.9
Ahmed, F.10
-
51
-
-
0033552813
-
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
-
Jacobs J.J., Kieboom K., Marino S., DePinho R.A., and van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397 (1999) 164-168
-
(1999)
Nature
, vol.397
, pp. 164-168
-
-
Jacobs, J.J.1
Kieboom, K.2
Marino, S.3
DePinho, R.A.4
van Lohuizen, M.5
-
52
-
-
0242667922
-
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
-
Molofsky A.V., Pardal R., Iwashita T., Park I.K., Clarke M.F., and Morrison S.J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425 (2003) 962-967
-
(2003)
Nature
, vol.425
, pp. 962-967
-
-
Molofsky, A.V.1
Pardal, R.2
Iwashita, T.3
Park, I.K.4
Clarke, M.F.5
Morrison, S.J.6
-
53
-
-
0038349957
-
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
-
Park I.K., Qian D., Kiel M., Becker M.W., Pihalja M., Weissman I.L., Morrison S.J., and Clarke M.F. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423 (2003) 302-305
-
(2003)
Nature
, vol.423
, pp. 302-305
-
-
Park, I.K.1
Qian, D.2
Kiel, M.3
Becker, M.W.4
Pihalja, M.5
Weissman, I.L.6
Morrison, S.J.7
Clarke, M.F.8
-
54
-
-
33846148370
-
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene
-
Kotake Y., Cao R., Viatour P., Sage J., Zhang Y., and Xiong Y. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev 21 (2007) 49-54
-
(2007)
Genes Dev
, vol.21
, pp. 49-54
-
-
Kotake, Y.1
Cao, R.2
Viatour, P.3
Sage, J.4
Zhang, Y.5
Xiong, Y.6
-
55
-
-
33947134834
-
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
-
Bracken A.P., Kleine-Kohlbrecher D., Dietrich N., Pasini D., Gargiulo G., Beekman C., Theilgaard-Monch K., Minucci S., Porse B.T., Marine J.C., et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 21 (2007) 525-530
-
(2007)
Genes Dev
, vol.21
, pp. 525-530
-
-
Bracken, A.P.1
Kleine-Kohlbrecher, D.2
Dietrich, N.3
Pasini, D.4
Gargiulo, G.5
Beekman, C.6
Theilgaard-Monch, K.7
Minucci, S.8
Porse, B.T.9
Marine, J.C.10
-
57
-
-
1342332096
-
Polycomb CBX7 has a unifying role in cellular lifespan
-
Gil J., Bernard D., Martinez D., and Beach D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol 6 (2004) 67-72
-
(2004)
Nat Cell Biol
, vol.6
, pp. 67-72
-
-
Gil, J.1
Bernard, D.2
Martinez, D.3
Beach, D.4
-
58
-
-
0037673984
-
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
-
Lessard J., and Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423 (2003) 255-260
-
(2003)
Nature
, vol.423
, pp. 255-260
-
-
Lessard, J.1
Sauvageau, G.2
-
59
-
-
0028201742
-
Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
-
van der Lugt N.M., Domen J., Linders K., van Roon M., Robanus-Maandag E., te Riele H., van der Valk M., Deschamps J., Sofroniew M., van Lohuizen M., et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8 (1994) 757-769
-
(1994)
Genes Dev
, vol.8
, pp. 757-769
-
-
van der Lugt, N.M.1
Domen, J.2
Linders, K.3
van Roon, M.4
Robanus-Maandag, E.5
te Riele, H.6
van der Valk, M.7
Deschamps, J.8
Sofroniew, M.9
van Lohuizen, M.10
-
60
-
-
65249121864
-
Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation
-
•] provide the evidences that expression of PcG proteins EZH2 or BMI-1 reduces with aging in pancreatic β cells, which is associated with observed increase in p16INK4a expression, diminished β cell mass and phenotypes of T2DM. These results suggest the possibility that a loss of PcG repression with aging contributes to the observed increase in expression of p16INK4a and aging phenotypes noted in several human tissues.
-
•] provide the evidences that expression of PcG proteins EZH2 or BMI-1 reduces with aging in pancreatic β cells, which is associated with observed increase in p16INK4a expression, diminished β cell mass and phenotypes of T2DM. These results suggest the possibility that a loss of PcG repression with aging contributes to the observed increase in expression of p16INK4a and aging phenotypes noted in several human tissues.
-
(2009)
Genes Dev
, vol.23
, pp. 906-911
-
-
Dhawan, S.T.1
Shuen-Ing2
Bhushan, A.3
-
61
-
-
33749350639
-
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice
-
Oguro H., Iwama A., Morita Y., Kamijo T., van Lohuizen M., and Nakauchi H. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 203 (2006) 2247-2253
-
(2006)
J Exp Med
, vol.203
, pp. 2247-2253
-
-
Oguro, H.1
Iwama, A.2
Morita, Y.3
Kamijo, T.4
van Lohuizen, M.5
Nakauchi, H.6
-
62
-
-
20544453888
-
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice
-
Bruggeman S.W., Valk-Lingbeek M.E., van der Stoop P.P., Jacobs J.J., Kieboom K., Tanger E., Hulsman D., Leung C., Arsenijevic Y., Marino S., et al. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 19 (2005) 1438-1443
-
(2005)
Genes Dev
, vol.19
, pp. 1438-1443
-
-
Bruggeman, S.W.1
Valk-Lingbeek, M.E.2
van der Stoop, P.P.3
Jacobs, J.J.4
Kieboom, K.5
Tanger, E.6
Hulsman, D.7
Leung, C.8
Arsenijevic, Y.9
Marino, S.10
-
63
-
-
0036499117
-
Transgenic expression of the p16(INK4a) cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4-CD8-immature thymocytes
-
Lagresle C., Gardie B., Eyquem S., Fasseu M., Vieville J.C., Pla M., Sigaux F., and Bories J.C. Transgenic expression of the p16(INK4a) cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4-CD8-immature thymocytes. J Immunol 168 (2002) 2325-2331
-
(2002)
J Immunol
, vol.168
, pp. 2325-2331
-
-
Lagresle, C.1
Gardie, B.2
Eyquem, S.3
Fasseu, M.4
Vieville, J.C.5
Pla, M.6
Sigaux, F.7
Bories, J.C.8
-
64
-
-
0035859813
-
Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages
-
Randle D.H., Zindy F., Sherr C.J., and Roussel M.F. Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages. Proc Natl Acad Sci U S A 98 (2001) 9654-9659
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 9654-9659
-
-
Randle, D.H.1
Zindy, F.2
Sherr, C.J.3
Roussel, M.F.4
-
65
-
-
0032490854
-
Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence
-
Erickson S., Sangfelt O., Heyman M., Castro J., Einhorn S., and Grander D. Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence. Oncogene 17 (1998) 595-602
-
(1998)
Oncogene
, vol.17
, pp. 595-602
-
-
Erickson, S.1
Sangfelt, O.2
Heyman, M.3
Castro, J.4
Einhorn, S.5
Grander, D.6
-
66
-
-
0035817688
-
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
-
Sharpless N.E., Bardeesy N., Lee K.H., Carrasco D., Castrillon D.H., Aguirre A.J., Wu E.A., Horner J.W., and DePinho R.A. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413 (2001) 86-91
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.H.3
Carrasco, D.4
Castrillon, D.H.5
Aguirre, A.J.6
Wu, E.A.7
Horner, J.W.8
DePinho, R.A.9
-
67
-
-
33745786808
-
The tumor suppressor p16(Ink4a) regulates T lymphocyte survival
-
Bianchi T., Rufer N., MacDonald H.R., and Migliaccio M. The tumor suppressor p16(Ink4a) regulates T lymphocyte survival. Oncogene 25 (2006) 4110-4115
-
(2006)
Oncogene
, vol.25
, pp. 4110-4115
-
-
Bianchi, T.1
Rufer, N.2
MacDonald, H.R.3
Migliaccio, M.4
-
68
-
-
0030612349
-
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
-
Zindy F., Quelle D.E., Roussel M.F., and Sherr C.J. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15 (1997) 203-211
-
(1997)
Oncogene
, vol.15
, pp. 203-211
-
-
Zindy, F.1
Quelle, D.E.2
Roussel, M.F.3
Sherr, C.J.4
-
69
-
-
1642561702
-
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
-
Melk A., Schmidt B.M., Takeuchi O., Sawitzki B., Rayner D.C., and Halloran P.F. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int 65 (2004) 510-520
-
(2004)
Kidney Int
, vol.65
, pp. 510-520
-
-
Melk, A.1
Schmidt, B.M.2
Takeuchi, O.3
Sawitzki, B.4
Rayner, D.C.5
Halloran, P.F.6
|