Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf

Genes and Development

Volumn 22, Issue 22, 2008, Pages 3115-3120

  Signer, Robert A J ^a   Montecino Rodriguez, Encarnacion ^a   Witte, Owen N ^a,b   Dorshkind, Kenneth ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Arf; Bmi 1; Cancer; Hematopoiesisl; p16ink4a

Indexed keywords

ARF PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CELL AGING; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; HEMATOPOIETIC STEM CELL; LYMPHOPOIESIS; MALIGNANT TRANSFORMATION; MOUSE; MYELOPOIESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGING; ANIMALS; B-LYMPHOCYTES; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FLOW CYTOMETRY; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 56549120340     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1715808     Document Type: Article

References (38)

1. Akashi, K., Traver, D., Miyamoto, T., and Weissman, I.L. 2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197.
2. Baker, D.J., Perez-Terzic, C., Jin, F., Pitel, K., Niederlander, N.J., Jeganathan, K., Yamada, S., Reyes, S., Rowe, L., Hiddinga, H.J., et al. 2008. Opposing roles for p16 Ink4a and p19 Arf in senescence and ageing caused by BubR1 insufficiency. Nat. Cell Biol. 10: 825-836.
3. Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173: 1213-1225.
4. Jacobs, J.J., Kieboom, K., Marino, S., DePinho, R.A., and van Lohuizen, M. 1999. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164-168.
5. Janzen, V., Forkert, R., Fleming, H.E., Saito, Y., Waring, M.T., Dombkowski, D.M., Cheng, T., DePinho, R.A., Sharpless, N.E., and Scadden, D.T. 2006. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443: 421-426.
6. Kamijo, T., Zindy, F., Roussel, M.F., Quelle, D.E., Downing, J.R., Ashmun, R.A., Grosveld, G., and Sherr, C.J. 1997. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91: 649-659.
7. Kim, W.Y. and Sharpless, N.E. 2006. The regulation of INK4/ARF in cancer and aging. Cell 127: 265-275.
8. Kondo, M., Weissman, I.L., and Akashi, K. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91: 661-672.
9. Krishnamurthy, J., Torrice, C., Ramsey, M.R., Kovalev, G.I., Al-Regaiey, K., Su, L., and Sharpless, N.E. 2004. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114: 1299-1307.
10. Krishnamurthy, J., Ramsey, M.R., Ligon, K.L., Torrice, C., Koh, A., Bonner-Weir, S., and Sharpless, N.E. 2006. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443: 453-457.
11. Matheu, A., Pantoja, C., Efeyan, A., Criado, L.M., Martin-Caballero, J., Flores, J.M., Klatt, P., and Serrano, M. 2004. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes & Dev. 18: 2736-2746.
12. Miller, J.P. and Allman, D. 2003. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J. Immunol. 171: 2326-2330.
13. Min, H., Montecino-Rodriguez, E., and Dorshkind, K. 2005. Effects of aging on early B- and T-cell development. Immunol. Rev. 205: 7-17.
14. Min, H., Montecino-Rodriguez, E., and Dorshkind, K. 2006. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J. Immunol. 176: 1007-1012.
15. Molofsky, A.V., Slutsky, S.G., Joseph, N.M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N.E., and Morrison, S.J. 2006. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443: 448-452.
16. Montecino-Rodriguez, E. and Dorshkind, K. 2006. Stromal cell-dependent growth of B-1 B cell progenitors in the absence of direct contact. Nat. Protocols 1: 1140-1144.
17. Mullighan, C.G., Williams, R.T., Downing, J.R., and Sherr, C.J. 2008. Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL. Genes & Dev. 22: 1411-1415.
18. Nielsen, G.P., Stemmer-Rachamimov, A.O., Shaw, J., Roy, J.E., Koh, J., and Louis, D.N. 1999. Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues. Lab. Invest. 79: 1137-1143.
19. Ohtani, N., Zebedee, Z., Huot, T.J., Stinson, J.A., Sugimoto, M., Ohashi, Y., Sharrocks, A.D., Peters, G., and Hara, E. 2001. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409: 1067-1070.
20. Park, I.K., Qian, D., Kiel, M., Becker, M.W., Pihalja, M., Weissman, I.L., Morrison, S.J., and Clarke, M.F. 2003. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423: 302-305.
21. Rossi, D.J., Bryder, D., Zahn, J.M., Ahlenius, H., Sonu, R., Wagers, A.J., and Weissman, I.L. 2005. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc. Natl. Acad. Sci. 102: 9194-9199.
22. Rossi, D.J., Jamieson, C.H., and Weissman, I.L. 2008. Stems cells and the pathways to aging and cancer. Cell 132: 681-696.
23. Sachs, Z., Sharpless, N.E., DePinho, R.A., and Rosenberg, N. 2004. p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis. J. Virol. 78: 3304-3311.
24. Serrano, M., Lee, H., Chin, L., Cordon-Cardo, C., Beach, D., and DePinho, R.A. 1996. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85: 27-37.
25. Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D., and Lowe, S.W. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602.
26. Sharpless, N.E. and DePinho, R.A. 2007. How stem cells age and why this makes us grow old. Nat. Rev. Mol. Cell Biol. 8: 703-713.
27. Sharpless, N.E., Bardeesy, N., Lee, K.H., Carrasco, D., Castrillon, D.H., Aguirre, A.J., Wu, E.A., Horner, J.W., and DePinho, R.A. 2001. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413: 86-91.
28. Sherr, C.J. 2001. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2: 731-737.
29. Sherr, C.J. and McCormick, F. 2002. The RB and p53 pathways in cancer. Cancer Cell 2: 103-112.
30. Signer, R.A., Montecino-Rodriguez, E., and Dorshkind, K. 2007a. Aging, B lymphopoiesis, and patterns of leukemogenesis. Exp. Gerontol. 42: 391-395.
31. Signer, R.A., Montecino-Rodriguez, E., Witte, O.N., McLaughlin, J., and Dorshkind, K. 2007b. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood 110: 1831-1839.
32. Spangrude, G.J., Heimfeld, S., and Weissman, I.L. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241: 58-62.
33. Stephan, R.P., Sanders, V.M., and Witte, P.L. 1996. Stage-specific alterations in murine B lymphopoiesis with age. Int. Immunol. 8: 509-518.
34. Van der Put, E., Frasca, D., King, A.M., Blomberg, B.B., and Riley, R.L. 2004. Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover. J. Immunol. 173: 818-827.
35. Williams, R.T., Roussel, M.F., and Sherr, C.J. 2006. Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. 103: 6688-6693.
36. Wong, S. and Witte, O.N. 2004. The BCR-ABL story: Bench to bedside and back. Annu. Rev. Immunol. 22: 247-306.
37. Yilmaz, O.H., Kiel, M.J., and Morrison, S.J. 2006. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107: 924-930.
38. Zindy, F., Quelle, D.E., Roussel, M.F., and Sherr, C.J. 1997. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15: 203-211.