MGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning

Neuropsychopharmacology

Volumn 34, Issue 9, 2009, Pages 2057-2071

  Ayala, Jennifer E ^a   Chen, Yelin ^a,e   Banko, Jessica L ^a   Sheffler, Douglas J ^a   Williams, Richard ^b   Telk, Alexandra N ^c   Watson, Noreen L ^c   Xiang, Zixiu ^a   Zhang, Yongqin ^a   Jones, Paulianda J ^a   Lindsley, Craig W ^a,b,d   Olive, M Foster ^c   Conn, P Jeffrey ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MUSC Center for Drug and Alcohol Programs   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Allosteric potentiator; Group I mGluR; LTD; LTP; MGluR5; Synaptic plasticity

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; D AP 5; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHOSPHATIDYLINOSITIDE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VU 29;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; HIPPOCAMPUS; LEARNING; LONG TERM DEPRESSION; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SPATIAL MEMORY;

ALLOSTERIC REGULATION; ANIMALS; EXCITATORY AMINO ACID AGENTS; GLUTAMIC ACID; HIPPOCAMPUS; LEARNING; LONG-TERM POTENTIATION; LONG-TERM SYNAPTIC DEPRESSION; MALE; MAZE LEARNING; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONAL PLASTICITY; PHOSPHATIDYLINOSITOLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SPACE PERCEPTION; SRC-FAMILY KINASES;

EID: 67651087294     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2009.30     Document Type: Article

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