Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

Neuroscience

Volumn 142, Issue 3, 2006, Pages 691-702

  Balschun, D ^a,b   Zuschratter, W ^a   Wetzel, W ^a  

^a LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

DFB; group I mGluRs; hippocampus; open field; spatial learning; Y maze

Indexed keywords

METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST;

ALLOSTERISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LEARNING; LONG TERM MEMORY; MALE; MEMORY CONSOLIDATION; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPATIAL MEMORY; TASK PERFORMANCE;

ALLOSTERIC REGULATION; ANIMALS; BEHAVIOR, ANIMAL; EXPLORATORY BEHAVIOR; HYDRAZINES; IMMUNOHISTOCHEMISTRY; MALE; MAZE LEARNING; MEMORY; NERVE TISSUE PROTEINS; PARVALBUMINS; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SPATIAL BEHAVIOR; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 33749245129     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.06.043     Document Type: Article

References (54)

1. Aggleton J.P., Hunt P.R., and Rawlins J.N. The effects of hippocampal lesions upon spatial and non-spatial tests of working memory. Behav Brain Res 19 (1986) 133-146
2. Backstrom P., Bachteler D., Koch S., Hyytia P., and Spanagel R. mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29 (2004) 921-928
3. Balazs R., Miller S., Romano C., de Vries A., Chun Y., and Cotman C.W. Metabotropic glutamate receptor mGluR5 in astrocytes: pharmacological properties and agonist regulation. J Neurochem 69 (1997) 151-163
4. Ballard T.M., Woolley M.L., Prinssen E., Huwyler J., Porter R., and Spooren W. The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison. Psychopharmacology (Berl) 179 (2005) 218-229
5. Balschun D., Manahan-Vaughan D., Wagner T., Behnisch T., Reymann K.G., and Wetzel W. A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning. Learn Mem 6 (1999) 138-152
6. Balschun D., and Wetzel W. Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. Pharmacol Biochem Behav 73 (2002) 375-380
7. Barker G.R., Bashir Z.I., Brown M.W., and Warburton E.C. A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory. Learn Mem 13 (2006) 178-186
8. Belozertseva I.V., Kos T., Popik P., Danysz W., and Bespalov A.Y. Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests. Eur Neuropsychopharmacol (2006). http://www.ncbi.nlm.nih.gov Apr 19 [Epub ahead of print]. http://www.ncbi.nlm.nih.gov
9. Borowicz K.K., Luszczki J.J., and Czuczwar S.J. SIB 1893, a selective mGluR5 receptor antagonist, potentiates the anticonvulsant activity of oxcarbazepine against amygdala-kindled convulsions in rats. Pol J Pharmacol 56 (2004) 459-464
10. Busse C.S., Brodkin J., Tattersall D., Anderson J.J., Warren N., Tehrani L., Bristow L.J., Varney M.A., and Cosford N.D. The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety. Neuropsychopharmacology 29 (2004) 1971-1979
11. Cahill L., McGaugh J.L., and Weinberger N.M. The neurobiology of learning and memory: some reminders to remember. Trends Neurosci 24 (2001) 578-581
12. Campbell U.C., Lalwani K., Hernandez L., Kinney G.G., Conn P.J., and Bristow L.J. The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology (Berl) 175 (2004) 310-318
13. Conn P.J., and Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37 (1997) 205-237 205-237
14. Cowen M.S., Djouma E., and Lawrence A.J. The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J Pharmacol Exp Ther 315 (2005) 590-600
15. Daniel H., Levenes C., Fagni L., Conquet F., Bockaert J., and Crepel F. Inositol-1,4,5-trisphosphate-mediated rescue of cerebellar long-term depression in subtype 1 metabotropic glutamate receptor mutant mouse. Neuroscience 92 (1999) 1-6
16. Deacon R.M., Bannerman D.M., Kirby B.P., Croucher A., and Rawlins J.N. Effects of cytotoxic hippocampal lesions in mice on a cognitive test battery. Behav Brain Res 133 (2002) 57-68
17. Fendt M., and Schmid S. Metabotropic glutamate receptors are involved in amygdaloid plasticity. Eur J Neurosci 15 (2002) 1535-1541
18. Francesconi W., Cammalleri M., and Sanna P.P. The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Res 1022 (2004) 12-18
19. Gravius A., Pietraszek M., Schafer D., Schmidt W.J., and Danysz W. Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning. Behav Pharmacol 16 (2005) 113-121
20. Huber K.M., Kayser M.S., and Bear M.F. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288 (2000) 1254-1257
21. Huber K.M., Roder J.C., and Bear M.F. Chemical induction of mGluR5- and protein synthesis-dependent long-term depression in hippocampal area CA1. J Neurophysiol 86 (2001) 321-325
22. Jia Z., Lu Y., Henderson J., Taverna F., Romano C., Abramow-Newerly W., Wojtowicz J.M., and Roder J. Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learn Mem 5 (1998) 331-343
23. Kleppisch T., Voigt V., Allmann R., and Offermanns S. G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region. J Neurosci 21 (2001) 4943-4948
24. Lindsley C.W., Wisnoski D.D., Leister W.H., O'Brien J.A., Lemaire W., Williams Jr. D.L., Burno M., Sur C., Kinney G.G., Pettibone D.J., Tiller P.R., Smith S., Duggan M.E., Hartman G.D., Conn P.J., and Huff J.R. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J Med Chem 47 (2004) 5825-5828
25. Lu Y.M., Jia Z., Janus C., Henderson J.T., Gerlai R., Wojtowicz J.M., and Roder J.C. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17 (1997) 5196-5205
26. Lujan R., Nusser Z., Roberts J.D., Shigemoto R., and Somogyi P. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur J Neurosci 8 (1996) 1488-1500
27. Lujan R., Roberts J.D., Shigemoto R., Ohishi H., and Somogyi P. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. J Chem Neuroanat 13 (1997) 219-241
28. Manahan-Vaughan D., and Braunewell K.H. The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity. Cereb Cortex. 15 (2005) 1703-1713
29. Moghaddam B. Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia. Psychopharmacology (Berl) 174 (2004) 39-44
30. Nagaraja R.Y., Grecksch G., Reymann K.G., Schroeder H., and Becker A. Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling, and kindling-related learning deficits. Naunyn Schmiedebergs Arch Pharmacol 370 (2004) 26-34
31. Naie K., and Manahan-Vaughan D. Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation. Cereb Cortex 14 (2004) 189-198
32. O'Brien J.A., Lemaire W., Chen T.B., Chang R.S., Jacobson M.A., Ha S.N., Lindsley C.W., Schaffhauser H.J., Sur C., Pettibone D.J., Conn P.J., and Williams Jr. D.L. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol 64 (2003) 731-740
33. O'Brien J.A., Lemaire W., Wittmann M., Jacobson M.A., Ha S.N., Wisnoski D.D., Lindsley C.W., Schaffhauser H.J., Rowe B., Sur C., Duggan M.E., Pettibone D.J., Conn P.J., and Williams Jr. D.L. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J Pharmacol Exp Ther 309 (2004) 568-577
34. Palucha A., Branski P., Szewczyk B., Wieronska J.M., Klak K., and Pilc A. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav 81 (2005) 901-906
35. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates (1997), Academic Press, San Diego
36. Petersen S., Bomme C., Baastrup C., Kemp A., and Christoffersen G.R. Differential effects of mGluR1 and mGlur5 antagonism on spatial learning in rats. Pharmacol Biochem Behav 73 (2002) 381-389
37. Pietraszek M., Sukhanov I., Maciejak P., Szyndler J., Gravius A., Wislowska A., Plaznik A., Bespalov A.Y., and Danysz W. Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats. Eur J Pharmacol 514 (2005) 25-34
38. Pych J.C., Chang Q., Colon-Rivera C., and Gold P.E. Acetylcholine release in hippocampus and striatum during testing on a rewarded spontaneous alternation task. Neurobiol Learn Mem 84 (2005) 93-101
39. Rasmussen K., Martin H., Berger J.E., and Seager M.A. The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats. Neuropharmacology 48 (2005) 173-180
40. Riedel G., Platt B., and Micheau J. Glutamate receptor function in learning and memory. Behav Brain Res 140 (2003) 1-47
41. Riedel G., Wetzel W., and Reymann K.G. Computer-assisted shock-reinforced Y-maze training: a method for studying spatial alternation behaviour. Neuroreport 5 (1994) 2061-2064
42. Rodrigues S.M., Bauer E.P., Farb C.R., Schafe G.E., and LeDoux J.E. The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala. J Neurosci 22 (2002) 5219-5229
43. Romano C., van den Pol A.N., and O'Malley K.L. Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain: protein, mRNA splice variants, and regional distribution. J Comp Neurol 367 (1996) 403-412
44. Salinska E. The role of group I metabotropic glutamate receptors in memory consolidation and reconsolidation in the passive avoidance task in 1-day-old chicks. Neurochem Int 48 (2006) 447-452
45. Schachtman T.R., Bills C., Ghinescu R., Murch K., Serfozo P., and Simonyi A. MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats. Behav Brain Res 141 (2003) 177-182
46. Schulz B., Fendt M., Gasparini F., Lingenhohl K., Kuhn R., and Koch M. The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats. Neuropharmacology 41 (2001) 1-7
47. Simonyi A., Schachtman T.R., and Christoffersen G.R. The role of metabotropic glutamate receptor 5 in learning and memory processes. Drug News Perspect 18 (2005) 353-361
48. Slassi A., Isaac M., Edwards L., Minidis A., Wensbo D., Mattsson J., Nilsson K., Raboisson P., McLeod D., Stormann T.M., Hammerland L.G., and Johnson E. Recent advances in non-competitive mGlu5 receptor antagonists and their potential therapeutic applications. Curr Top Med Chem 5 (2005) 897-911
49. Spooren W.P., Vassout A., Neijt H.C., Kuhn R., Gasparini F., Roux S., Porsolt R.D., and Gentsch C. Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents. J Pharmacol Exp Ther 295 (2000) 1267-1275
50. Wetzel W., and Balschun D. Improvement of memory retention following posttraining activation of mGluR5 receptors by CHPG (RS-2-chloro-5-hydroxyphenylglycine). FENS Abstr 1 A107.30 (2002) 276
51. Wieronska J.M., Szewczyk B., Branski P., Palucha A., and Pilc A. Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats. Amino Acids 23 (2002) 213-216
52. Williams Jr. D.L., and Lindsley C.W. Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5). Curr Top Med Chem 5 (2005) 825-846
53. Wilsch V.W., Behnisch T., Jager T., Reymann K.G., and Balschun D. When are class I metabotropic glutamate receptors necessary for long-term potentiation?. J Neurosci 18 (1998) 6071-6080
54. Yu J., Huang Y.W., and Chen Z. [Improved alternative electro-stimulus Y-maze for evaluating the spatial memory of rats]. Zhejiang Da Xue Xue Bao Yi Xue Ban 32 (2003) 121-125 140