Differential regulation of metabotropic glutamate receptor 5-mediated phosphoinositide hydrolysis and extracellular signal-regulated kinase responses by protein kinase C in cultured astrocytes

Journal of Neurochemistry

Volumn 83, Issue 1, 2002, Pages 110-118

  Peavy, Richard D ^a   Sorensen, Scott D ^a   Conn, P Jeffrey ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Astrocytes; Desensitization; Extracellular signal regulated kinase 2; Metabotropic glutamate receptor 5; Phosphoinositide hydrolysis; Protein kinase C

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 5; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITIDE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; HYDROLYSIS; NEGATIVE FEEDBACK; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ASTROCYTES; CALCIUM SIGNALING; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME ACTIVATORS; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GLYCINE; HYDROLYSIS; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RESORCINOLS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0036789065     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01113.x     Document Type: Article

References (32)

1. Alagarsamy S., Marino M. J., Rouse S. T., Gereau R. W., Heinemann S. F. and Conn P. J. (1999) Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems. Nat. Neurosci. 2, 234-240.
2. Alagarsamy S., Sorensen S. D. and Conn P., J. (2001) Coordinate regulation of metabotropic glutamate receptors. Curr. Opin. Neurobiol. 11, 357-362.
3. Alaluf S., Mulvihill E. R. and McIlhinney R. A. J. (1995) The metabotropic glutamate receptor mGluR4, but not mGluR1α is palmitoylated when expressed in BHK cells. J. Neurochem. 64, 1548-1555.
4. Balázs R., Miller S., Romano C., de Vries A., Chun Y. and Cotman C. W. (1997) Metabotropic glutamate receptor mGluR5 in astrocytes: pharmacological properties and agonist regulation. J. Neurochem. 69, 151-163.
5. Canonico P. L., Favit A., Catania M. V. and Nicoletti F. (1988) Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures. J. Neurochem. 51, 1049-1053.
6. Catania M. V., Aronica E., Sortino M. A., Canonico P. L. and Nicoletti F. (1991) Desensitization of metabotropic glutamate receptors in neuronal cultures. J. Neurochem. 56, 1329-1335.
7. Chuang T. T., Iacovelli L., Sallese M. and De Blasi A. (1996) G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Trends Pharmacol. Sci. 17, 416-421.
8. Ciruela F., Soloviev M. M. and McIlhinney R. A. (1999) Co-expression of metabotropic glutamate receptor type 1α with Homer-1a/Ves1-1S increases the cell surface expression of the receptor. Biochem. J. 341, 795-803.
9. Conn P. J. and Pin J.-P. (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37, 205-237.
10. Dale L. B., Bhattacharya M., Anborgh P. H., Murdoch B., Bhatia M., Nakanishi S. and Ferguson S. S. (2000) G protein-coupled receptor kinase-mediated desensitization of metabotropic glutamate receptor 1A protects against cell death. J. Biol. Chem. 275, 38213-38220.
11. De Blasi A., Conn P. J., Pin J.-P. and Nicoletti F. (2000) Molecular determinants in the regulation of metabotropic glutamate receptor signaling. Trends Pharmacol. Sci. 22, 114-120.
12. Ferguson S. S. G. (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 53, 1-24.
13. Ferraguti F., Baldani-Guerra B., Corsi M., Nakanishi S. and Corti C. (1999) Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors. Eur. J. Neurosci. 11, 2073-2082.
14. 2+ pathway by phosphorylation of the receptor-G protein-coupling domain. Proc. Natl Acad. Sci. USA 97, 6185-6190.
15. Freedman N. J. and Lefkowitz R. J. (1996) Desensitization of G protein-coupled receptors. Recent Prog. Horm. Res. 51, 319-353.
16. Gereau R. W. and Heinemann S. F. (1998) Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5. Neuron 20, 143-151.
17. Godfrey P. P. and Taghavi Z. (1990) The effect of non-NMDA antagonists and phorbol esters on excitatory amino acid-stimulated inositol phosphate formation in rat cerebral cortex. Neurochem. Int. 16, 65-72.
18. Herrero I., Miras-Portugal M. T. and Sanchez-Prieto J. (1994) Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals. Eur. J. Neurosci. 6, 115-120.
19. Herrero I., Miras-Portugal M. T. and Sanchez-Prieto J. (1998) Functional switch from facilitation to inhibition in the control of glutamate release by metabotropic glutamate receptors. J. Biol. Chem. 273, 1951-1958.
20. Heuss C., Scanziani M., Gahwiler B. H. and Gerber U. (1999) G-protein-independent signaling mediated by metabotropic glutamate receptors. Nat. Neurosci. 2, 1070-1077.
21. Manzoni O. J., Finiels-Marlier F., Sassetti I., Blockaert J., le Peuch C. and Sladeczek F. A. (1990) The glutamate receptor of the Qp-type activates protein kinase C and is regulated by protein kinase C. Neurosci. Lett. 109, 146-151.
22. McCarthy K. D. and de Vellis J. (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85, 890-902.
23. Miller S., Bridges R. J. and Cotman C. W. (1993) Stimulation of phosphoinositide hydrolysis by trans-(±)-ACPD is greatly enhanced When astrocytes are cultured in a serum-free defined medium. Brain Res. 618, 175-178.
24. Miller S., Romano C. and Cotman C. W. (1995) Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes. J. Neurosci. 15, 6103-6109.
25. Nicoletti F., Wroblewski J. T., Novelli A., Alho H., Guidotti A. and Costa E. (1986) The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. J. Neurosci. 6, 1905-1911.
26. Peavy R. D. and Conn P. J. (1998) Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors. J. Neurochem. 71, 603-612.
27. Peavy R. D., Chang M. S. S., Sanders-Bush E. and Conn P. J. (2001) Metabotropic glutamate receptor 5-mediated phosphorylation of extracellular regulated signal kinase 2 is dependent on transactivation of the epidermal growth factor receptor. J. Neurosci. 21, 9619-9628.
28. Rodriguez-Moreno A., Sistiaga A., Lerma J. and Sanchez-Prieto J. (1998) Switch from facilitation to inhibition of excitatory synaptic transmission by group I mGluR desensitization. Neuron 21, 1477-1486.
29. Sallese M., Salvatore L., D'Urbano E., Sala G., Sorto M., Launey T., Nicoletti F., Knopfel T. and De Blasi A. (2000) The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1. FASEB J. 14, 2569-2580.
30. Schoepp D. D. and Johnson B. G. (1988) Excitatory amino acid agonistantagonist interactions at 2-amino-4-phosphonobutyric acid-sensitive quisqualate receptors coupled to phosphoinositide hydrolysis in slices of rat hippocampus. J. Neurochem. 50, 1605-1613.
31. Thomsen C., Mulvihill E. R., Haldeman B., Pickering D. S., Hampson D. R. and Suzdak P. D. (1993) A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line. Brain Res. 619, 22-28.
32. Toullec D., Pianetti P., Coste H., Bellevergue P., Grand-Perret T., Ajakane M., Baudet V., Boissin P., Boursier E., Loriolle F., Duhamel L., Charon D. and Kirilovsky J. (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 15771-15781.