Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes

Journal of Medicinal Chemistry

Volumn 49, Issue 11, 2006, Pages 3332-3344

  De Paulis, Tomas ^a   Hemstapat, Kamondanai ^a   Chen, Yelin ^a   Zhang, Yongqin ^a   Saleh, Samir ^a   Alagille, David ^b   Baldwin, Ronald M ^b   Tamagnan, Gilles D ^b   Conn, P Jeffrey ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROPHENYL) 3 [3 (4 FLUOROPHENYL)[1,2,4]OXADIAZOL 5 YL]PIPERIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 CYANO N (1,3 DIPHENYL 1H PYRAZOL 5 YL)BENZAMIDE; 4 NITRO N [1 (2 FLUOROPHENYL) 3 PHENYL 1H PYRAZOL 5 YL]BENZAMIDE; ADX 47273; BENZAMIDE DERIVATIVE; CALCIUM; GLUTAMIC ACID; HALOGEN; METABOTROPIC RECEPTOR 5; N (1,3 DIPHENYL 1H PYRAZOL 5 YL)BENZAMIDE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; VU 1545;

ALLOSTERISM; ARTICLE; ASTROCYTE; BINDING AFFINITY; BINDING SITE; BRAIN CELL; BRAIN CORTEX; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; EMBRYO; FLUOROMETRY; HUMAN; HUMAN CELL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; ASTROCYTES; BENZAMIDES; BINDING SITES; BINDING, COMPETITIVE; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; HUMANS; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 33744801125     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051252j     Document Type: Article

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